Bone marrow aspirate concentrate (Stem cells) therapy for pre-collapse stage of AVN of femoral head: An interventional comparative study

Jain, Apoorv; Daultani, Deepesh; Doshi, Karan; Palanivel, A.; Syed, Taosef; Kumar, Manoj; Shetty, M. Shantharam; Pai, Shailesh

doi:10.22271/ortho.2020.v6.i4n.2448

Cited by 1 publication

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“…Regarding this, various treatment methods ranging from conservative care to surgical treatments have been studied. 9,10 But there are no established treatments and more effective treatment options need to be developed. 11 Core decompression is the most common surgery performed on patients in the pre-collapse stage.…”

Section: Introductionmentioning

confidence: 99%

“…11 Core decompression is the most common surgery performed on patients in the pre-collapse stage. 9 Core decompression was first described by Ficat and Alert, 12 and its effectiveness was proved to some extent by a lot of studies afterwards. 1,13 The basic concept of core decompression is to reduce the increased intra-medullary pressure and re-establish the blood flow, thus preventing the progression of the disease and inducing regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Cell therapy for osteonecrosis of femoral head and joint preservation

Chun

Lee

Won

et al. 2022

Journal of Clinical Orthopaedics and Trauma

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Osteonecrosis of femoral head (ONFH) is a disease of the femoral head and can cause femoral head collapse and arthritis. This can lead to pain and gait disorders. ONFH has various risk factors, it is often progressive, and if untreated results in secondary osteo-arthritis. Biological therapy makes use of bone marrow concentrate, cultured osteoblast and mesenchymal stem cell (MSC) obtained from various sources. These are often used in conjunction with core decompression surgery. In this review article, we discuss the current status of cell therapy and its limitations. We also present the future development of biological approach to treat ONFH.

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Section: Introductionmentioning

confidence: 99%