Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Akçay, Serkan; Kazımoğlu, Cemal

doi:10.1007/s11999-014-3637-3

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…Thus, platelet-rich plasma (PRP) is usually applied for healing musculoskeletal soft tissue injuries 36 . Moreover, some recent studies have reported that PRP could enhance bone healing 37,38 . Undoubtedly, the SECCS enriches both MSCs and platelets simultaneously to promote bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

Bone Mesenchymal Stem Cell-Enriched β-Tricalcium Phosphate Scaffold Processed by the Screen-Enrich-Combine Circulating System Promotes Regeneration of Diaphyseal Bone Non-Union

et al. 2018

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Bone non-union after fracture, considered a therapeutic challenge for orthopedics, always needs a reversion surgery, including autograft transplantation (AGT). However, adverse events related to autograft harvest cannot be ignored. Our group designed a novel system called the bone marrow stem cell Screen-Enrich-Combine Circulating System (SECCS) by seeding mesenchymal stem cells (MSCs) into β-tricalcium phosphate (β-TCP) during surgery to thereafter rapidly process bioactive bone implantation. In this retrospective case-control study, 30 non-union patients who accepted SECCS therapy and 20 non-union patients who accepted AGT were enrolled. By SECCS therapy, the MSC-enriched β-TCP particles were implanted into the non-union gap. During the enrichment procedure, a significant proportion of MSCs were screened and enriched from bone marrow into porous β-TCP particles, and the cells possessed the capacity for three-line differentiation and were CD90+/CD105+/CD34-/CD45-. Approximately 82.0±10.7% of MSCs were enriched from 60 mL bone marrow without damaging cell viability, and approximately 11,444.0±6,018 MSCs were transplanted per patient. No implant-related infections occurred in any case. After 9 months of follow-up, 27 patients (90%) in the SECCS group acquired clinical union, compared with 18 patients (90%) in the AGT group (clinical union time, P = 0.064), and postoperative radiographic union score at 9 months post-operation was similar between the two groups. In conclusion, the SECCS could concentrate a large proportion of MSCs from bone marrow to acquire enough effective cells for therapy without in vitro cell culture. Bone substitutes processed by SECCS demonstrated encouraging promotion of bone regeneration and showed a satisfactory clinical curative effect for diaphyseal bone non-union, which was non-inferior to AGT.

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Section: Discussionmentioning

confidence: 99%

Bone Mesenchymal Stem Cell-Enriched β-Tricalcium Phosphate Scaffold Processed by the Screen-Enrich-Combine Circulating System Promotes Regeneration of Diaphyseal Bone Non-Union

et al. 2018

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“…After an average of 2.95 months, the patients reported a 95% accomplished clinical and radiological union rate. Additionally, BMAC and platelet rich plasma (PRP) have been proved to work well together in the treatment of nonunion [21] . However, because they were not assessed independently, it is unclear if BMAC, PRP, or both produce this result.…”

Section: Case Illustrations Casementioning

confidence: 99%

To study the union rates and complications of percutaneous bone marrow injection in delayed union of long bone fractures: A prospective study

Karthik¹,

Bb²,

MK³

2023

Int. J. Orthop. Sci.

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Introduction: Fracture healing is a form of wound healing that involves bone regeneration and leads to the restoration of skeletal integrity. Despite recent developments fracture stabilisation and understanding of biological healing processes, delayed union remains a challenging clinical condition. Bone marrow being abundant in osteoprogenitor cells is being tried to enhance the fracture healing. This study emphasizes the proficiency of bone marrow injected at the fracture site with delayed union and to reduce the time of morbidity for patients who are at the risk of development of non-union. Aim: To study the union rates and complications of percutaneous bone marrow injection at the site of delayed union of long bone fractures.

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Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches

et al. 2017

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Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Cited by 6 publications

References 2 publications

Bone Mesenchymal Stem Cell-Enriched β-Tricalcium Phosphate Scaffold Processed by the Screen-Enrich-Combine Circulating System Promotes Regeneration of Diaphyseal Bone Non-Union

Bone Mesenchymal Stem Cell-Enriched β-Tricalcium Phosphate Scaffold Processed by the Screen-Enrich-Combine Circulating System Promotes Regeneration of Diaphyseal Bone Non-Union

To study the union rates and complications of percutaneous bone marrow injection in delayed union of long bone fractures: A prospective study

Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches

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