Bone marrow aspirate concentrate – A novel approach to alter the course of temporomandibular joint osteoarthritis (a clinical study)

Fayed, Heba Mohamed; Khairy, Maggie A; Eldahshan, Dina; Sabry, Dina; Ahmed, Waheed A.

doi:10.1016/j.jormas.2023.101644

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…By incorporating MSCs into the treatment, BMAC aims to alleviate symptoms and actively contribute to regenerating damaged joint tissues. Additionally, including growth factors further enhances BMAC's regenerative potential, as these bioactive molecules play crucial roles in tissue repair and modulating the local environment within the joint [ 22 ].…”

Section: Reviewmentioning

confidence: 99%

“…By directly tapping into the regenerative potential in the patient's bone marrow, BMAC presents a promising avenue for addressing the root causes of knee osteoarthritis. Understanding the fundamental principles and applications of BMAC is imperative for assessing its efficacy and safety in managing knee osteoarthritis [ 22 ]. This entails comprehensively comprehending the biological mechanisms through which BMAC exerts its therapeutic effects and evaluating its potential benefits and risks.…”

Section: Reviewmentioning

confidence: 99%

“…As research into BMAC continues to evolve, the knowledge gained will contribute to refining treatment protocols, optimising patient selection criteria, and enhancing the overall effectiveness of regenerative therapies for knee osteoarthritis. The ongoing exploration of BMAC's applications holds the potential to reshape the landscape of osteoarthritis management, offering a promising avenue for those seeking alternatives to traditional treatments [ 22 ].…”

Section: Reviewmentioning

confidence: 99%

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Navigating the Therapeutic Landscape: A Comprehensive Review of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate in Knee Osteoarthritis

Balusani,

Shrivastava,

Pundkar

et al. 2024

Cureus

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This comprehensive review provides an in-depth analysis of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) as potential treatments for knee osteoarthritis. It explores their mechanisms of action, clinical efficacy, safety considerations, and the importance of personalised treatment approaches. The review highlights promising findings regarding the ability of PRP and BMAC to alleviate symptoms, improve joint function, and potentially slow disease progression. It emphasises the need for further research into long-term outcomes, direct comparative studies, protocol standardisation, biomarker identification, and cost-effectiveness assessments to enhance clinical practice. While the review does not directly compare PRP and BMAC, it provides valuable insights into their respective roles in knee osteoarthritis management. The review aims to contribute to evidence-based advancements in regenerative therapies for knee osteoarthritis by addressing critical research priorities and refining treatment strategies.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Navigating the Therapeutic Landscape: A Comprehensive Review of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate in Knee Osteoarthritis

Balusani,

Shrivastava,

Pundkar

et al. 2024

Cureus

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Arthrocentesis for temporomandibular joint disorders: a network meta-analysis of randomised controlled trials

Zhang,

Yun,

Zhou

et al. 2024

BMC Oral Health

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Objective Clinical studies have demonstrated the effectiveness of arthrocentesis in managing temporomandibular joint disorders (TMDs). However, there is a lack of consensus among these studies regarding the selection of injectables. Furthermore, an increasing number of drugs have been tested for TMDs in recent years, complicating the decision-making process for clinicians. This study conducted a network meta-analysis of randomized controlled trials (RCTs) to compare the clinical efficacy of different arthrocentesis treatment regimens. Methods We conducted a comprehensive search of Embase, PubMed, Cochrane Library, and Web of Science to gather articles on RCTs pertaining to the management of TMDs using arthrocentesis. This search spanned from inception of these databases up to July 29, 2024. We then performed a network meta-analysis using Stata 17.0 software. The outcome indicators used were VAS scores and changes in unassisted maximum opening. To determine the efficacy of each regimen, we employed surface-under the cumulative ranking curve (SUCRA) ranking. Result Forty RCTs were included, encompassing 1904 temporomandibular joints (TMJs) cases. Treatment options encompass platelet-rich plasma (PRP), hyaluronic acid (HA), corticosteroids (CS), bone marrow concentrate (BMAC), injectable platelet-rich fibrin (i-PRF), concentrated growth factor (CGF), Tenoxicam (TX), microfragmented adipose tissue (FAT), and their combination regimens. The SUCRA ranking revealed that the most effective treatment options at 1-, 3-, and 6-months post-arthrocentesis were HA + PRP, i-PRF, and BMAC, respectively. Conclusion HA + PRP, i-PRF and BMAC may represent the optimal arthrocentesis agents for the management of TMDs symptoms and restoration of TMJ function in the short, medium, and long term, respectively. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD42024563975. Supplementary Information The online version contains supplementary material available at 10.1186/s12903-024-04858-7.

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Update on Evidence and Directions in Temporomandibular Joint Injection Techniques: A Rapid Review of Primary Research

Lubecka,

Chęcińska,

Bliźniak

et al. 2024

JCM

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This rapid review summarizes the latest primary research in temporomandibular joint (TMJ) injection treatment. The final literature searches were conducted on 4 January 2024. Selection was performed systematically following predefined eligibility criteria. Randomized control trials concerning the treatment of TMJ disorders with intra-articular injections were included. Studies on more invasive interventions were excluded. Quality of life, joint pain and range of mandibular mobility were assessed. Ultimately, 12 studies covering a total of 603 patients qualified. They concerned: (1) arthrocentesis (AC) and the administration of, (2) injectable platelet-rich fibrin (I-PRF), (3) platelet-rich plasma (PRP), (4) hyaluronic acid (HA), (5) non-steroidal anti-inflammatory drugs (NSAIDs), and (6) hypertonic dextrose (HD) with a local anesthetic. The dominant approach was to perform arthrocentesis before administering the appropriate injection substance (I-PRF, PRP, HA, or NSAID). Two current studies on the intra-articular administration of NSAIDs, specifically tenoxicam and piroxicam, are noteworthy. A mixture of PRP and HA was injected in another two trials. These two innovative approaches may prove to be significant directions for further research on injection treatment of TMJs.

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Bone marrow aspirate concentrate – A novel approach to alter the course of temporomandibular joint osteoarthritis (a clinical study)

Cited by 3 publications

References 30 publications

Navigating the Therapeutic Landscape: A Comprehensive Review of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate in Knee Osteoarthritis

Navigating the Therapeutic Landscape: A Comprehensive Review of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate in Knee Osteoarthritis

Arthrocentesis for temporomandibular joint disorders: a network meta-analysis of randomised controlled trials

Update on Evidence and Directions in Temporomandibular Joint Injection Techniques: A Rapid Review of Primary Research

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