Bone Marrow as Multidimensional Orbit Oscillator after Autologous Bone Marrow Transplantation

Hájek, Dobroslav; Kubešová, Hana Matějovská; Vyzula, Rostislav; Mayer, Jiřı́; Miloslav, Druckmueller,; Tomíška, Miroslav; Vašků, Anna

doi:10.1002/stem.170025

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…Again, when bone marrow function recovers, the increase of sodium excretion precedes the increase of granulocytes in blood, which indicates the recovery of bone marrow function (Fig. 2) [5,8].…”

Section: Experimental Evidencementioning

confidence: 85%

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Extracellular volume regulation and growth

et al. 2005

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We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extracellular volume (ECV) was calculated to be about 23% of total body volume (TV). Stereo metric solution suggested the cubic cell cluster formed by 8-cells. This hypothesis (Solution l) explains the ECV to be compatible with the widely accepted value (about 23% of TV). In addition, the 8-cell cluster hypothesis explains the existence of ECV oscillation with the period of about seven days. This hypothesis probably describes the dominant type of growth in humans. Solution 2, in this type of growth, ECV fills about 77% per cent of TV. Instead of the 8-cell cube, in this type of proliferation 4-cells could form a tetrahedron. This type of growth could be beneficial in processes where free space in tissue or organ must be filled for example in peptic ulcer healing and namely in repopulating of free space in a bone after high dose chemotherapy.

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Section: Experimental Evidencementioning

confidence: 85%

“…This is typical after a high dose of chemotherapy and consecutive bone marrow transplantation. In this status, the function F period ranges from 2 to 3 days [8]. The cell cycle time [10] that is limited makes generation of tetrahedrons composed of 4-cells more probable.…”

Section: Experimental Evidencementioning

confidence: 99%

Extracellular volume regulation and growth

et al. 2005

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“…Dobroslav Hájek et al [1] proved the correlation between sodium and potassium changes and granulocyte counts in peripheral blood, recorded later. The amplitude maximum (FFmax) of function F n = ([Na] n ‐[Na] n‐1 )/([K] n ‐[K] n‐ 1 ), where n is day number, [Na] and [K] are sodium and potassium excretion, predicted the granulocyte count in peripheral blood (GR), recorded k days later.…”

Section: To the Editormentioning

confidence: 99%

“…We have found the f decreases to 0.06 day −1 on day 22 and FFmax decreases to 0.08 day −1 corresponding to day 23. Due to the calculation method [1], the FFmax decrease estimation was not possible earlier than on day 26 (Fig. 1).…”

Section: To the Editormentioning

confidence: 99%

Sodium and Potassium Excretion Changes and Bone Marrow Recovery after Chemotherapy

Kiss¹,

Tomášek²

1999

STEM CELLS

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“…The RAAS includes the angiotensin I converting enzyme (ACE), which may be associated with increased cell proliferation (12). The main mechanism responsible for that function is cleavage by ACE enzyme of proteins, which show anti-proliferative effect on bone marrow cells (13).…”

Section: Introductionmentioning

confidence: 99%

ACE Insertion/Deletion Polymorphism (rs4646994) Is Associated With the Increased Risk of Multiple Myeloma

et al. 2019

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Introduction: The insertion (I allele) deletion (D allele) polymorphism of ACE gene (rs4646994) may influence the etiopathogenesis of multiple myeloma (MM). ACE gene is expressed in bone marrow cells and encodes angiotensin converting enzyme (ACE). It converts angiotensin I to active peptide angiotensin II, which stimulates proliferation of hematopoietic stem cells. This suggests possible association of ACE I/D gene polymorphism with MM. The aim of our study was to check possible impact of this polymorphism on risk of development and outcome of MM, as well as, sensitivity to bortezomib in cell cultures derived from MM patients.Objects and Methods: Genomic DNA from 98 newly diagnosed MM patients and 100 healthy blood donors were analyzed by PCR method. Chromosomal aberrations were detected by use of cIg-FISH. In a subgroup of 40 MM patients nucleated bone marrow cells were treated with bortezomib in vitro.Results: The Hardy-Weinberg equilibrium test showed that genotypic frequencies diverged significantly from the equilibrium. The differences between I and D allele frequencies in control and study population were significant (p = 0.046). We observed the association between DD genotype and more than 2-fold risk of MM - OR = 2.69; p < 0.0001. We did not detect any significant differences among studied genotypes regarding clinical and laboratory parameters. Moreover, we did not observe the association between survival of MM patients and I/D genotypes. Bortezomib increased number of apoptotic and necrotic cells, but the only statistically significant differences were observed in the number of viable cells at 1 nM between ID and DD genotypes (p = 0.026).Conclusion: Presented results confirmed the significant relationship between ACE (I/D) polymorphism and risk of MM development. We did not observe the association of ACE I/D polymorphism with disease outcome and bortezomib in vitro sensitivity.

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Bone Marrow as Multidimensional Orbit Oscillator after Autologous Bone Marrow Transplantation

Cited by 7 publications

References 15 publications

Extracellular volume regulation and growth

Extracellular volume regulation and growth

Sodium and Potassium Excretion Changes and Bone Marrow Recovery after Chemotherapy

ACE Insertion/Deletion Polymorphism (rs4646994) Is Associated With the Increased Risk of Multiple Myeloma

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