Bone Marrow Abnormalities Detected by Magnetic Resonance Imaging as Initial Sign of Hematologic Malignancies

Grønningsæter, Ida Sofie; Ahmed, Aymen Bushra; Vetti, Nils; Johansen, Silje; Bruserud, Øystein; Reikvam, Håkon

doi:10.4081/cp.2018.1061

Cited by 8 publications

(5 citation statements)

References 16 publications

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“…Malignancies that can present with bone marrow signal abnormality include acute lymphoblastic leukemia, acute promyelocytic leukemia, chronic myeloid leukemia, and infiltrative lymphoma ( 15 , 16 ). Of these, B-cell acute lymphoblastic leukemia is most commonly associated with STIR bone marrow abnormality, and may occur prior to lymphoblast detection in the peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

Chronic Non-infectious Osteomyelitis Mimicking Scurvy as the Presenting Sign of Crohn’s Disease: Case Report

et al. 2022

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Chronic non-infectious osteomyelitis (CNO) is a rare, inflammatory process associated with pediatric inflammatory bowel disease (IBD). Signs and symptoms of CNO parallel scurvy, a nutritional deficiency that can affect children with autism spectrum disorder (ASD). This is the first report of a child initially thought to have scurvy, then subsequently diagnosed with CNO as the presenting manifestation of Crohn’s disease. This case enhances the literature elucidating extra-intestinal manifestations of IBD and pediatric nutritional deficiencies.

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Section: Discussionmentioning

confidence: 99%

Chronic Non-infectious Osteomyelitis Mimicking Scurvy as the Presenting Sign of Crohn’s Disease: Case Report

et al. 2022

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“…Although characteristic imaging findings of bone marrow infiltration by malignant cells have been extensively studied on magnetic resonance imaging (MRI) (7–11), there have been few reports of CT findings of bone marrow infiltration in patients with AML. Although bone marrow CT attenuation has been known to sometimes increase in patients with myeloproliferative disorders, there has only been one case report that described increased bone marrow CT attenuation in a patient with AML (12).…”

Section: Discussionmentioning

confidence: 99%

A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia

et al. 2022

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Background Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Bone marrow computed tomography (CT) attenuation may increase in patients with myeloproliferative disorders; however, the actual threshold CT attenuation value predictive of myeloproliferative has not been reported. Purpose To determine whether the unenhanced CT attenuation value of the bone marrow may be useful for predicting AML. Material and Methods We retrospectively analyzed patients with AML (n = 56) who underwent unenhanced CT before treatment, and age- and sex-matched controls without any hematologic disease. For each patient, the CT attenuation value (HU) of the iliac bone was measured and compared between the two groups. Receiver operating characteristic (ROC) curve analysis was used to define the cutoff value for predicting AML on all patients, and only on late elderly patients (aged ≥75 years). Results Patients with AML showed higher bone marrow CT attenuation value (131.4 ± 58.3 vs. 53.9 ± 67.2 HU; P < 0.001), compared to the controls. The sensitivity and specificity for the diagnosis of AML in all patients were 78.6% and 80.4%, respectively, at a threshold value of 90 HU, whereas they were 83.3% and 91.7%, respectively, at 40 HU in late elderly patients. Conclusion The iliac bone CT attenuation value was elevated in patients with AML and may be useful for predicting AML.

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“…The usefulness of femoral marrow MRI has been reported in several studies; 2 , 3 , 15 - 17 however, there have been few reports on femoral marrow MRI for BM involvement. Recently, most MRI reports related to NHL have determined the stage.…”

Section: Discussionmentioning

confidence: 99%

Femoral marrow MRI is a non-invasive, non-irradiated and useful tool for detecting bone marrow involvement in non-Hodgkin lymphoma

Ikeda

Tsunoda

Koyama

et al. 2021

J Clin Exp Hematopathol

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Magnetic resonance imaging (MRI) is a non-invasive and non-irradiated diagnostic method. MRI has higher resolution of fatty tissue and cellular tissue than other modalities. Although there have been several studies evaluating bone marrow (BM) involvement in hematological disorders in a clinical setting, 1-3 the significance of MRI for examining BM involvement remains unclear. According to the various guidelines for hematological disorders, BM aspiration and biopsy are still gold standards for determining BM involvement positivity or negativity. [4][5][6][7][8] Because BM aspirate and biopsy are collected from only the sternum or ilium, they do not necessarily reflect the overall condition of the BM. Positron emission tomography-computed tomography (PET-CT) has been recommended as an aid for determining the stage of malignant lymphoma. However, information on marrow conditions below the pelvis generally cannot be obtained from PET-CT.BM is the largest hematopoietic organ in mammals. Hematopoiesis in BM continues throughout life and changes according to the distribution of red marrow and yellow marrow. 3 Fatty replacement of functioning hematopoietic marrow occurs in the periphery of the appendicular skeleton. In long bones, such as the femur, fatty marrow spreads from the diaphysis and epiphyses to metaphyses. 9,10 Hematopoietic marrow remains throughout life in only the proximal metaphysis in the femur. During aging, other femur marrow is replaced with yellow marrow. 3 MRI enables the evaluation of the entire BM compartment without invasive examinations, such as BM aspiration and biopsy. We specifically developed the femoral MRI method to visualize the entire

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Bone Marrow Abnormalities Detected by Magnetic Resonance Imaging as Initial Sign of Hematologic Malignancies

Cited by 8 publications

References 16 publications

Chronic Non-infectious Osteomyelitis Mimicking Scurvy as the Presenting Sign of Crohn’s Disease: Case Report

Chronic Non-infectious Osteomyelitis Mimicking Scurvy as the Presenting Sign of Crohn’s Disease: Case Report

A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia

Femoral marrow MRI is a non-invasive, non-irradiated and useful tool for detecting bone marrow involvement in non-Hodgkin lymphoma

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