Bone Margin Analysis for Benign Odontogenic Tumors

Ringer, Eric; Kolokythas, Antonia

doi:10.1016/j.coms.2017.03.006

Cited by 21 publications

(6 citation statements)

References 39 publications

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“…Oda et al 32 showed a close spatial relationship and/or association between odontomas and the GT on CBCTs, noticeable in exams of individuals less than 20 years of age (>96%). Indeed, benign odontogenic tumors represent a heterogeneous group of lesions developed from the various components of the odontogenic apparatus, 33 which encompass some similarity with RO regarding etiopathogenesis. In addition, the present case emphasizes the importance of CBCT to accurately detect GT, since panoramic radiography usually does not reveal this finding.…”

Section: Discussionmentioning

confidence: 99%

Mandibular Regional Odontodysplasia in an 8-year-old Boy showing Teeth Disorders, Gubernaculum Tracts, and Altered Bone Fractal Pattern

Cavalcante

Fonteles

Ribeiro

et al. 2018

International Journal of Clinical Pediatric Dentistry

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Regional odontodysplasia (RO) is a rare nonhereditary developmental condition usually affecting maxilla and female patients. A few number of articles have used the cone beam computed tomography (CBCT) to describe imaging findings in RO. Thus, this article aims to report unusual imaging findings in a Brazilian child who presented with mandibular RO. A healthy 8-year-old boy was referred for evaluation of an anterior mandibular gingival enlargement. Radiographically, all right mandibular teeth showed wide pulp chambers and shortened roots with thin dentinal walls and open apices, featuring a “ghost teeth“ appearance, which indicated a diagnosis of RO. Missing teeth and altered radiopacity were observed. Cone beam computed tomography provided great insight into RO, allowing to identify gubernaculum tracts (GTs) associated with RO teeth. Fractal analysis of the bone surrounding RO teeth revealed an altered trabecular pattern.Clinical significanceThis case describes a rare developmental teeth-related pathology in a boy who showed unusual features on imaging exams. The CBCT provided the observation of RO tooth-related GTs, probably a new finding added to the international literature regarding RO, as well as the pulp chamber volume characterization of an affected tooth not published yet. In addition, it was observed an altered fractal pattern of the mandibular bone adjacent to RO teeth, which has not been described to date.How to cite this article: de Sa Cavalcante D, Fonteles CSR, Ribeiro TR, Kurita LM, Pimenta AVM, Carvalho FSR, Costa FWG. Mandibular Regional Odontodysplasia in an 8-year-old Boy showing Teeth Disorders, Gubernaculum Tracts, and Altered Bone Fractal Pattern. Int J Clin Pediatr Dent 2018;11(2):128-134.

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Section: Discussionmentioning

confidence: 99%

Mandibular Regional Odontodysplasia in an 8-year-old Boy showing Teeth Disorders, Gubernaculum Tracts, and Altered Bone Fractal Pattern

Cavalcante

Fonteles

Ribeiro

et al. 2018

International Journal of Clinical Pediatric Dentistry

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“…36 It is crucial to distinguish between radiographic margins and surgical margins assessed in the histopathological examination, as well as to be aware of their dependence. 45 Both Pogrel and Marx 46 and Carlson and Montes 41 suggest a 1 to 1.5 cm radiographic resection margin in case of mandibular ameloblastomas as the sufficient one. The conclusion of Pogrel was based on the findings of Gumgum and Hosgoren, who revealed that in histological sectioning of resected mandible containing ameloblastoma the tumor cells could be found up to 8 mm from the radiographic and clinical margin of the lesion.…”

Section: Discussionmentioning

confidence: 98%

“…In the case of segmental mandibulectomy, the extent of adequate margin has been discussed over the years 36. It is crucial to distinguish between radiographic margins and surgical margins assessed in the histopathological examination, as well as to be aware of their dependence 45. Both Pogrel and Marx46 and Carlson and Montes41 suggest a 1 to 1.5 cm radiographic resection margin in case of mandibular ameloblastomas as the sufficient one.…”

Section: Discussionmentioning

confidence: 99%

Fibular Free Flap and Iliac Crest Free Flap Mandibular Reconstruction In Patients With Mandibular Ameloblastomas

Piotrowska-Seweryn

Szymczyk

Walczak

et al. 2022

Journal of Craniofacial Surgery

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: Ameloblastoma (AM) is the most common, locally aggressive odontogenic tumor. It comprises about 1% of all head and neck neoplasms. It occurs mainly in young adults in their 3rd and 4th decade of life. It localizes in the mandible in about 80% of the cases. According to the 2017 WHO classification, 4 types of ameloblastoma can be distinguished: ameloblastoma (previously referred to as solid/multicystic-SMA; the “conventional type” AM), unicystic (AM-UA), extraosseous/peripheral (AM-PA), and malignant/metastatic (AM-MA). Solid, multicystic is the most common type. It is characteristic for its aggressiveness and high risk of recurrence. Radical resection with consecutive reconstruction is the treatment of choice of mandibular ameloblastomas. In this study, the authors present their experience in the surgical treatment of mandibular ameloblastomas with vascularized free flap reconstructions. They discuss new technological possibilities that could improve the precision of the reconstructive procedure and therefore result in the better aesthetic outcome. The retrospective study of a group of 21 patients suffering from mandibular ameloblastoma who underwent segmental man-dibulectomy with simultaneous microvascular free flap reconstruction was conducted. A thorough clinical analysis with various aspects was performed. Tumors resected before 2017 were double checked patomorphologically and assigned to the corrected subtype group. Seven patients were admitted to the department due to recurrent ameloblastoma. The most common localization of the tumor was the mandibular body (n = 6) andbodywith ramus of the mandible (n = 6). A total amount of 10 iliac crest free flaps and 12 fibular free flaps were performed. Complications were reported in 4 patients. A purulent oro-cutaneus fistula occurred in 3 patients. There was a flap failure in each reconstructive group. The virtual surgical planning with intraoperative cone-beam computed tomography was used in 3 patients. Dentition implantation was conducted in 4 patients (3 simultaneously, 1 postponed). The mean follow-up was 5 years and 8 months. Radical resection that covers radical segmental mandibulect-omy with immediate microvascular free flap reconstruction is a first-line and only effective treatment of mandibular ameloblas-tomas, that eliminates the risk of recurrence. The extent of surgical margins seems not to influence the recurrence rate, yet further investigation with statistical analysis should be performed. The choice of the adequate free flap must be adapted to dimensions and localization of the tumor and to each patient individually. New technologies such as virtual surgical planning with 3D models and intraoperative cone-beam computed tomography can make the reconstruction more accurate, improving patient's quality of life.

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“…Identification of clinical-surgical factors for recurrence, as well as the histological, cellular, and/or molecular understanding, could help in the construction of better clinical, prognostic, and follow-up decisions [ 37 , 38 , 39 , 40 ]. The histopathological analysis trying to associate the follicular, plexiform, acanthomatous, or other patterns with their pathogenesis or prognosis is controversial.…”

Section: Discussionmentioning

confidence: 99%

Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis

et al. 2022

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Ameloblastoma is a rare benign epithelial odontogenic neoplasm, but with great clinical implications, as despite its benignity and slow growth, most cases are locally aggressive with a significant recurrence rate. Histological, cellular, or molecular analyses of its pathogenesis have confirmed the complexity of this neoplasm. We present the case of a 20-year-old patient with a suggestive clinical and radiographic diagnosis of ameloblastoma. An incisional biopsy was obtained confirming the diagnosis of conventional ameloblastoma. Left hemimandibulectomy and plate reconstruction were performed. Histopathological analysis of the surgical specimen confirmed the conventional ameloblastoma with a plexiform pattern and significant areas of cystic degeneration and amyloid-like-like deposits. Additionally, a microarray was carried out with bioinformatic analysis for the enrichment, protein interaction, and determination of eight hub genes (CRP, BCHE, APP, AKT1, AGT, ACTC1, ADAM10, and APOA2) related to their pathogenesis.

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Bone Margin Analysis for Benign Odontogenic Tumors

Cited by 21 publications

References 39 publications

Mandibular Regional Odontodysplasia in an 8-year-old Boy showing Teeth Disorders, Gubernaculum Tracts, and Altered Bone Fractal Pattern

Mandibular Regional Odontodysplasia in an 8-year-old Boy showing Teeth Disorders, Gubernaculum Tracts, and Altered Bone Fractal Pattern

Fibular Free Flap and Iliac Crest Free Flap Mandibular Reconstruction In Patients With Mandibular Ameloblastomas

Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis

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