Bone loss and wrist fractures after withdrawal of hormone therapy: The 15-year follow-up of the OSTPRE cohort

Saarelainen, J.; Hassi, Saara; Honkanen, Risto; Koivumaa‐Honkanen, Heli; Sirola, Joonas; Kröger, Heikki; Komulainen, Marja; Tuppurainen, Marjo

doi:10.1016/j.maturitas.2015.12.011

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…The follow-up to the WHI study showed no increase in fractures five years after HRT withdrawal [80]. In another observational study (after 15 years of follow-up), conserved beneficial effects on bone were reported in women who used HRT for more than five years [81]. However, in a large study, Islam and colleagues found that the risk of fractures in postmenopausal women increased in the three years following the publication of the WHI [82].…”

Section: Fracturesmentioning

confidence: 99%

The Controversial History of Hormone Replacement Therapy

Cagnacci¹,

Venier²

2019

Medicina

126

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The history of hormone replacement therapy (HRT) started in the 1960s, with very high popularity in the 1990s. The first clinical trials on HRT and chronic postmenopausal conditions were started in the USA in the late 1990s. After the announcement of the first results of the Women’s Health Initiative (WHI) in 2002, which showed that HRT had more detrimental than beneficial effects, HRT use dropped. The negative results of the study received wide publicity, creating panic among some users and new guidance for doctors on prescribing HRT. The clear message from the media was that HRT had more risks than benefits for all women. In the following years, a reanalysis of the WHI trial was performed, and new studies showed that the use of HRT in younger women or in early postmenopausal women had a beneficial effect on the cardiovascular system, reducing coronary disease and all-cause mortality. Notwithstanding this, the public opinion on HRT has not changed yet, leading to important negative consequences for women’s health and quality of life.

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Section: Fracturesmentioning

confidence: 99%

The Controversial History of Hormone Replacement Therapy

Cagnacci¹,

Venier²

2019

Medicina

126

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“…The effect of HT withdrawal on bone loss has been mostly studied in postmenopausal women and the results are controversial. Most studies indicate that discontinuation of HT is followed by accelerated bone loss, but long-term use of HT (over 10–15 years) protects women from bone loss (30). We were not able to demonstrate a significant relationship between current HT use and bone loss in the FSHRO cohort.…”

Section: Discussionmentioning

confidence: 99%

Long-term health of women with genetic POI due to FSH-resistant ovaries

Luiro

Aittomäki

Jousilahti

et al. 2019

Endocrine Connections

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Objective To study the use of hormone therapy (HT), morbidity and reproductive outcomes of women with primary ovarian insufficiency (POI) due to FSH-resistant ovaries (FSHRO). Design A prospective follow-up study in a university-based tertiary clinic setting. Methods Twenty-six women with an inactivating A189V FSH receptor mutation were investigated by means of a health questionnaire and clinical examination. Twenty-two returned the health questionnaire and 14 were clinically examined. Main outcome measures in the health questionnaire were reported as HT, morbidity, medication and infertility treatment outcomes. In the clinical study, risk factors for cardiovascular disease (CVD) and metabolic syndrome (MetS) were compared to age-matched controls from a national population survey (FINRISK). Average number of controls was 326 per FSHRO subject (range 178–430). Bone mineral density and whole-body composition were analyzed with DXA. Psychological and sexual well-being was assessed with Beck Depression Inventory (BDI21), Generalized Anxiety Disorder 7 (GAD-7) and Female Sexual Function Index (FSFI) questionnaires. Results HT was initiated late (median 18 years of age) compared with normal puberty and the median time of use was shorter (20–22 years) than the normal fertile period. Osteopenia was detected in 9/14 of the FSHRO women despite HT. No major risk factors for CVD or diabetes were found. Conclusions HT of 20 years seems to be associated with a similar cardiovascular and metabolic risk factor profile as in the population control group. However, optimal bone health may require an early-onset and longer period of HT, which would better correspond to the natural fertile period.

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Epidemiology of Distal Radius Fractures

Davis

Chung

2021

Distal Radius Fractures

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Distal radius fractures are one of the most common types of fractures, accounting for around 25% of fractures in the pediatric population and up to 18% of all fractures in the elderly age group. Although the pediatric and elderly populations are at the greatest risk for this injury, distal radius fractures still have a significant impact on the health and well-being of young adults. Data from the past 40 years has documented a trend towards an overall increase in the prevalence of this injury. For the pediatric population, this increase can likely be attributed to a surge in sports related activities. The growth of the elderly population and a rise in the number of active elderly are directly responsible for the increase seen in this age group. Understanding the epidemiology of this fracture is an important step towards the improvement of the treatment strategies and preventative measures which target this debilitating injury.

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Bone loss and wrist fractures after withdrawal of hormone therapy: The 15-year follow-up of the OSTPRE cohort

Cited by 7 publications

References 31 publications

The Controversial History of Hormone Replacement Therapy

The Controversial History of Hormone Replacement Therapy

Long-term health of women with genetic POI due to FSH-resistant ovaries

Epidemiology of Distal Radius Fractures

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