Bone Like Arterial Calcification in Femoral Atherosclerotic Lesions: Prevalence and Role of Osteoprotegerin and Pericytes

Abstract

These results suggest that bone like arterial calcification (OM) is highly prevalent at femoral level. Pericyte cells and the OPG/RANK/RANKL triad seem to be critical to the formation of this ectopic osteoid tissue and represent interesting potential therapeutic targets to reduce the clinical impact of arterial calcification.

Identification of Key Pathways and Genes in Advanced Coronary Atherosclerosis Using Bioinformatics Analysis

“…Downregulated genes were mainly involved in cytoskeleton organization, cellular component organization, and positive regulation of cellular process and confirm the recent findings [ 15 – 17 ] ( Table 3 ). Besides, as shown in Table 4 , the KEGG analysis showed that upregulated genes participate in osteoclast differentiation [ 18 – 20 ], cytokine-cytokine receptor interaction [ 21 ], and chemokine signaling pathway [ 22 – 24 ]. Downregulated genes took part in focal adhesion [ 25 – 27 ], regulation of actin cytoskeleton [ 27 – 29 ], and arrhythmogenic right ventricular cardiomyopathy (ARVC) [ 30 ].…”

Management of common femoral artery occlusive disease: A review of endovascular treatment strategies and outcomes

“…Only data from a single‐center retrospective study by Stavroulakis et al found the 1‐year primary patency of DCB in CFA disease to be 68% and a TLR rate of 25% . The limited efficacy was primarily attributed to high rates of osteoid metaplasia and heavy calcifications found in CFA atherosclerotic plaques, which may prove to be more amenable to debulking strategies …”

“…In addition, a significant difference in the rate of failure following CFA reconstruction was noted from BASI, with six cases of stent failure due to CFA occlusion, compared to no events for CFE ( P = 0.02). The role of bioabsorbable stents in atherosclerotic CFA occlusive disease appears initially to be limited, as bioabsorbable stents lack the radial force for heavily calcified lesions in the CFA typified by osteoid metaplasia, though further randomized trials are needed …”

Impact of Vascular Calcifications on Long Femoropopliteal Stenting Outcomes

“…Despite being exposed to similar risk factors, peripheral arteries develop heterogeneous atherosclerotic lesions. Our previous work showed that carotid arteries develop predominantly lipid-rich lesions and microcalcifications, while femoral arteries develop fibrotic lesions, with extensive vascular calcification (VC) and frequent presence of osteoid tissue (1)(2)(3)(4). These differences may have major clinical implications.…”