Bone ingrowth on the surface of endosseous implants. Part 1: Mathematical model

Moreo, P.; García-Aznar, J.M.; Doblaré, M.

doi:10.1016/j.jtbi.2008.07.040

Cited by 54 publications

(104 citation statements)

References 75 publications

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“…In this section we describe the most relevant characteristics of the mathematical model for peri-implant bone ingrowth that was developed in Part 1 of the paper (Moreo et al, 2008). In this model a continuum approach is adopted and therefore reaction-diffusion equations are used to compute the spatio-temporal evolution of the volumetric concentration of each specie.…”

Section: Mathematical Modelling Of Bone Ingrowthmentioning

confidence: 99%

“…The reader is referred to Part 1 of the paper (Moreo et al, 2008) for a more thorough discussion on the model.…”

Section: Mathematical Modelling Of Bone Ingrowthmentioning

confidence: 99%

“…Only, for simplicity, the stimulating effect of s 2 on the secretion of s 2 by osteoblasts and osteogenic cells has been assumed to be the same for both cellular types. Also, note that given that this reduced model does not include platelets or the growth factor s 1 , it is not suitable for the study of the effect of surface microtopography upon osteogenesis (Moreo et al, 2008). However, the general features of the osteoconduction phenomenon are independent of the type of osteogenesis, so still relevant information can be obtained from the reduced model.…”

Section: Description Of the Simplified Modelmentioning

confidence: 99%

“…In Part 1 of this paper (Moreo et al, 2008) the complete model was numerically solved by means of the finite element method in a geometry corresponding to the cavity between two threads of a dental implant and host bone in which the implant was placed. The simulations were performed with two different implant surface microtopographies to show the ability of the model to reproduce the differences between contact and distance osteogenesis.…”

Section: Description Of the Simulationmentioning

confidence: 99%

“…In Part 1 of this work a model to study the formation of bone around endosseous implants was presented (Moreo et al, 2008). This model is composed by a set of coupled nonlinear reaction-diffusion equations, one for each of the eight variables of the model: three types of cells (platelets, osteogenic cells and osteoblasts), two generic types of growth factors (secreted by platelets and secreted by osteogenic cells and osteoblasts) and the volume fractions of the extracellular matrix constituents (fibrin network, woven inmature bone and lamellar mature bone).…”

Section: Introductionmentioning

confidence: 99%

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Bone ingrowth on the surface of endosseous implants. Part 2: Theoretical and numerical analysis

Moreo¹,

García-Aznar²,

Doblaré³

2009

Journal of Theoretical Biology

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Section: Mathematical Modelling Of Bone Ingrowthmentioning

confidence: 99%

“…The reader is referred to Part 1 of the paper (Moreo et al, 2008) for a more thorough discussion on the model.…”

Section: Mathematical Modelling Of Bone Ingrowthmentioning

confidence: 99%

Section: Description Of the Simplified Modelmentioning

confidence: 99%

Section: Description Of the Simulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bone ingrowth on the surface of endosseous implants. Part 2: Theoretical and numerical analysis

Moreo¹,

García-Aznar²,

Doblaré³

2009

Journal of Theoretical Biology

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Application of Bioreactor Concept and Modeling Techniques to Bone Regeneration and Augmentation Treatments

Deccó¹,

Zuchuat²

2016

Advanced Surfaces for Stem Cell Research

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During almost two decades of research in the field of Tissue Engineering and Regenerative Medicine, a variety of biomaterials and techniques have been developed, and a series of results and clinical evidence have been published to support and improve bone regeneration and augmentation processes. The latest techniques include the use of growth factors and platelet-rich plasma preparations in combination with natural or artificial scaffolds, membranes, and stem cells. However, the application of these concepts depends heavily on a favorable microenvironment for the regeneration, which is provided by the use of the bioreactor. The bioreactor is a system in which a microenvironment can be created to promote bone regeneration by providing favorable biomechanical conditions, protecting against infection, and allowing proper nutrition of the regenerating tissue by vascularization. The latest research in this field is very promising as preliminary studies have shown good results concerning bone quality and architecture. In relation to the bioreactor principle, computational modeling represents a very effective tool to predict bone ingrowth. In addition, based on the obtained results, the use of these data to prevent diseases in the human osseous-articular system is expected in the near future.

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Deconvoluting the Bioactivity of Calcium Phosphate‐Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties

Galván-Chacón

Habibović

2017

Adv Healthcare Materials

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Calcium phosphate (CaP)-based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physico-chemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial-and-error approach to a design-driven approach in the development of new functional biomaterials. This progress report critically reviews various strategies developed to decouple the roles of the individual material properties in the biological performance of CaP ceramics. It furthermore emphasizes on the importance of a comprehensive and adequate material characterization that is needed to enhance our knowledge of the property-function relationship of biomaterials used in bone regeneration, and in regenerative medicine in general.

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Bone ingrowth on the surface of endosseous implants. Part 1: Mathematical model

Abstract: International audienc

Cited by 54 publications

References 75 publications

Bone ingrowth on the surface of endosseous implants. Part 2: Theoretical and numerical analysis

Bone ingrowth on the surface of endosseous implants. Part 2: Theoretical and numerical analysis

Application of Bioreactor Concept and Modeling Techniques to Bone Regeneration and Augmentation Treatments

Deconvoluting the Bioactivity of Calcium Phosphate‐Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties

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