Bone in CKD: why the ERA EDTA CKD-MBD working group organized a dedicated meeting?

Mazzaferro, Sandro; Massy, Ziad A.; Vervloet, Marc G.; Cozzolino, Mario

doi:10.1007/s40620-017-0436-4

Cited by 3 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…There is increasing awareness that BMD in kidney dialysis patients is a condition not just simply limited to biochemical abnormalities [27]. We report that lower BMD, evaluated by DXA, at the femoral neck but not at the lumbar spine were associated with greater aPWV, reinforcing the hypothesis of a link between bone disease and vascular disease in dialysis patients.…”

Section: Discussionsupporting

confidence: 67%

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density

Tangvoraphonkchai

Davenport

2018

J Nephrol

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Section: Discussionsupporting

confidence: 67%

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density

Tangvoraphonkchai

Davenport

2018

J Nephrol

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“…These effects on mineral homeostasis cause bone disorders. Recently, an increasing number of biologic and epidemiologic evidence has indicated that the two conditions share common pathophysiologic factors, and the bone also plays an active role in CKD-MBD [2]. Bone-kidney interactions via bone-derived substances such as fibroblast growth factor-23 (FGF-23), sclerostin, or osteocalcin may be implicated in CKD-MBD [3].…”

Section: Introductionmentioning

confidence: 99%

Risk factors and renal outcomes of low bone mineral density in patients with non-dialysis chronic kidney disease

et al. 2020

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Bone disorder is a common complication of chronic kidney disease (CKD). The clinical usefulness of bone mineral density (BMD) in CKD is not well known. Our study shows that low BMD is associated with physical activity and dietary Na/K intake ratio and can predict poor renal outcome in non-dialysis CKD. Purpose Despite evidence of a link between bone mineral disorders and chronic kidney disease (CKD), the clinical implications of bone mineral density (BMD) in CKD are not well established. We investigated risk factors and renal outcomes of low BMD in CKD. Methods We analyzed data from the KNOW-CKD. BMD measured by dual-energy x-ray absorptiometry was classified by T score: normal (T score ≥ − 1.0), osteopenia (− 1.0 > T score > − 2.5), and osteoporosis (T score ≤ − 2.5) of the lumbar spine, hip, or femoral neck. Logistic regression analysis to assess risk factors of low BMD (T score < − 1.0) and Cox proportional hazards models to estimate risk of incident end-stage renal disease (ESRD). Results Low BMD was prevalent (osteopenia 33%; osteoporosis 8%) in 2128 adults with CKD (age 54 ± 12 years; male 61%). Over a median follow-up of 4.3 years, there were 521 cases of incident ESRD. Lower BMD was associated with female sex, older age, low eGFR, low BMI, and lifestyle factors of physical activity (odds ratio (OR) = 0.62, 95% confidence interval (0.49-0.77)) and spot urine Na/K ratio (1.07 (1.00-1.15)). In adjusted Cox models, low BMD was associated with increased incident ESRD (hazard ratio (HR) = 1.14 (0.92-1.41) for osteopenia; 1.43 (1.01-2.04) for osteoporosis, P for trend < 0.05) compared with the reference of normal BMD. The association between low BMD and ESRD was similar according to T score discordance classification. Conclusions Low BMD was associated with modifiable lifestyle factors including low physical activity and high dietary Na/K intake ratio. The presence of low BMD is associated with poor renal outcomes in non-dialysis CKD.

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A rat model of SHPT with bone abnormalities in CKD induced by adenine and a high phosphorus diet

Tang

et al. 2018

Biochemical and Biophysical Research Communications

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Bone in CKD: why the ERA EDTA CKD-MBD working group organized a dedicated meeting?

Cited by 3 publications

References 6 publications

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density

Risk factors and renal outcomes of low bone mineral density in patients with non-dialysis chronic kidney disease

A rat model of SHPT with bone abnormalities in CKD induced by adenine and a high phosphorus diet

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