Bone Histomorphometry in Early Diagnosis of a Monoclonal Gammopathy of Undetermined Significance Ten Years Before Clinical Evidence

Bones Are Diamonds In The Rough

“…The study by Pascaretti et a1 is an excellent example of how the utilization of multiple technologies can elicitinformation crucial to an accurate diagnosis (16). The combination of bone histomorphometry for recognizing microresorption associated with a monoclonal gammopathy of undetermined significance with TRAP enzyme cytbchemistry provides important insights into the role of soluble factors like cytokines on osteoclasts.…”