Bone histomorphometry and vitamin D status after biliopancreatic bypass for obesity

Effect of a Single ‘Megadose’ Intramuscular Vitamin D (600,000 IU) Injection on Vitamin D Concentrations and Bone Mineral Density Following Biliopancreatic Diversion Surgery

“…They found significant decreases in serum VitD concentrations and lumbar spine BMD, whereas bone turnover increased [7]. Also, Compston et al [5] found that metabolic bone disease was present in 73% of patients followed for 1-5 years after BPD despite VitD levels being maintained in normative ranges in most patients, although comparisons with the current study are complicated due to different surgery techniques used for that study. In light of the previous findings, it appears that patients undergoing oral VitD supplementation only, experience progression of bone disease post-BPD, whereas our findings indicate that the current VitD injection therapy may have some advantages in improving progression of bone disease (especially if administered annually).…”

“…BPD has been shown to result in effective maintenance of long-term weight loss [2,3], but it has been well-established in the scientific literature that several undesirable metabolic consequences may occur as a result of BPD [3,4]. Chief amongst these are the deleterious effect on calcium homeostasis, serum vitamin D (VitD) concentrations and bone health [4][5][6][7][8]. Many bariatric centres commonly employ a regimen of nutritional supplements with the aim to maintain normal body physiology during the long-term post-operative follow-up [9].…”

Evaluation of Bone Disease in Morbidly Obese Women After Gastric Bypass and Risk Factors Implicated in Bone Loss

“…On the other hand, a decrease in bone mineral content has been described in patients following very-low-calorie diets [9], and epidemiological data, from the population-based Framingham Osteoporosis Study, also revealed that weight loss is an independent risk factor for osteoporosis [10]. Bone mass loss has been reported in patients undergoing operations for obesity, such as vertical banded gastroplasty [11], jejunoileal bypass [12,13] or biliopancreatic diversion [14], and osteomalacia has been described frequently after gastrectomy for peptic ulcers or cancer [15][16][17]. Although gastric bypass is increasingly being used as a treatment option for morbid obesity, few data are available regarding the impact of this surgery on the skeleton.…”

Effect of Roux-en Y Gastric Bypass on Bone Metabolism in Patients with Morbid Obesity: Mansoura Experiences

“…Especially when the weight loss occurs rapidly, there is an increase of low bone mass [11], metabolic bone disease [12,13], and fracture [14]. The aim of the present study was to evaluate the effects of RYGBP on bone metabolism after 1-year postoperative period in morbidly obese patients.…”