Bone Hierarchical Structure: Heterogeneity and Uniformity

Rodriguez‐Palomo, Adrian; Østergaard, Maja; Birkedal, Henrik

doi:10.1002/adfm.202307026

Cited by 6 publications

(3 citation statements)

References 122 publications

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“…Cortical bone comprises densely packed osteons with concentric rings surrounding a central canal. Additionally, cortical bone is anisotropic and has a 5%–15% porosity ( Morgan et al, 2018 ; Rodriguez Palomo et al, 2023 ; Zhou et al, 2023 ). Furthermore, the cortical bone has a transverse elastic modulus of 10.1 ± 2.4 GPa and a longitudinal elastic modulus of 17.9 ± 3.9 GPa ( Reilly and Burstein, 1975 ).…”

Section: Gelatin-based Hydrogels Printed Formulation For Btementioning

confidence: 99%

Bioprinting of gelatin-based materials for orthopedic application

Waidi,

Kariim,

Datta

2024

Front. Bioeng. Biotechnol.

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Bio-printed hydrogels have evolved as one of the best regenerative medicine and tissue engineering platforms due to their outstanding cell-friendly microenvironment. A correct hydrogel ink formulation is critical for creating desired scaffolds that have better fidelity after printing. Gelatin and its derivatives have sparked intense interest in various biomedical sectors because of their biocompatibility, biodegradability, ease of functionalization, and rapid gelling tendency. As a result, this report emphasizes the relevance of gelatin-based hydrogel in fabricating bio-printed scaffolds for orthopedic applications. Starting with what hydrogels and bio-printing are all about. We further summarized the different gelatin-based bio-printing techniques explored for orthopedic applications, including a few recent studies. We also discussed the suitability of gelatin as a biopolymer for both 3D and 4D printing materials. As extrusion is one of the most widely used techniques for bio-printing gelatin-based, we summarize the rheological features of gelatin-based bio-ink. Lastly, we also elaborate on the recent bio-printed gelatin-based studies for orthopedics applications, the potential clinical translation issues, and research possibilities.

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Section: Gelatin-based Hydrogels Printed Formulation For Btementioning

confidence: 99%

Bioprinting of gelatin-based materials for orthopedic application

Waidi,

Kariim,

Datta

2024

Front. Bioeng. Biotechnol.

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“…Bone structure can vary, ranging from immature woven bone, characterized by a chaotic arrangement of loosely packed fibrils, to mature lamellar bone, which features densely packed collagen fibers aligned parallel within each lamella but with alternating orientations across lamellae . Lamellar bone develops during the bone remodeling process, where osteoblasts align in a polarized manner along a surface, depositing collagen fibrils in a parallel orientation . Besides collagen, a smaller fraction of the organic matrix includes noncollagenous proteins (NCPs), which are crucial for the assembly of collagen fibrils and their subsequent mineralization.…”

Section: Introductionmentioning

confidence: 99%

“… 12 Lamellar bone develops during the bone remodeling process, where osteoblasts align in a polarized manner along a surface, depositing collagen fibrils in a parallel orientation. 13 Besides collagen, a smaller fraction of the organic matrix includes noncollagenous proteins (NCPs), which are crucial for the assembly of collagen fibrils and their subsequent mineralization. This combination of the collagen network, the organization of individual collagen fibrils, and NCPs serve as a foundational template for mineralization, significantly influencing the final structure of the ECM.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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Recent Advances in the Field of Bioinspired Materials and Systems

Zollfrank,

Selhuber‐Unkel

2024

Adv Funct Materials

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Bioinspired and biomimetic materials have revolutionized many aspects in the engineering sciences, ranging from basic technologies to advanced applications such as the Gecko's nanostructure for sticky tapes or the sharkskin for swimming suits. Research in these subjects in Germany has been supported by several national priority research programs since 2009 (SPP 1420: Biomimetic Materials Research: Functionality by Hierarchical Structuring of Materials, [1] SPP 1569: Generation of Multifunctional Inorganic Materials by Molecular Bionics, 2012-2019 [2] ), which strongly accelerated developments and investigations in the field. Recently, also photonic applications of bioinspired strategies have come within reach, demonstrating the huge potential of the approach nature has chosen in many directions (SPP 1839: Tailored Disorder -A science-and engineering-based approach to materials design for advanced photonic applications, 2015-2024 [3] ). These developments have been accompanied by a biennial DGM Bioinspired Materials conference series, which was launched in 2012. [4] The present Advanced Functional Materials feature issue now proudly presents accompanying papers from the 6 th DGM "Bioinspired Materials [5] " together with additional most recent and advanced research work pushing the limits of our exciting interdisciplinary research field. The collected perspectives, reviews and research articles represent the current state-of-the-art in the design of functional and structural materials and systems inspired by principles found in living nature. Main topics of this include the study and formation of hierarchical structures and the properties of complex-shaped biological materials. The transfer of biological principles into functional materials and systems made of organic and/or inorganic components represents a further main area. Beside synthesis and

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Bone Hierarchical Structure: Heterogeneity and Uniformity

Cited by 6 publications

References 122 publications

Bioprinting of gelatin-based materials for orthopedic application

Bioprinting of gelatin-based materials for orthopedic application

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Recent Advances in the Field of Bioinspired Materials and Systems

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