Bone-Healing Patterns Affected by Loading, Fracture Fragment Stability, Fracture Type, and Fracture Site Compression

Aro, Hannu T.; Chao, Edmund Y.S.

doi:10.1097/00003086-199308000-00003

Cited by 146 publications

(115 citation statements)

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“…This allows axial loads to cross the fracture site [1]. This biocompression produces better contact of the fracture fragments with adaptation to the physiological conditions of the interfragmentary tissue [17].…”

Section: Discussionmentioning

confidence: 99%

Mechanical analysis of the healing of different osteotomies fixed externally

Mora

Forriol

2000

International Orthopaedics

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Under standard conditions the left tibia was osteotomised in nine sheep. The osteotomy was transverse in six, and oblique in three. The osteotomies were fixated using a strain-gauge-monitored unilateral external fixator. The fixation was rigid in three sheep with a transverse osteotomy (group 1) and also in three sheep with an oblique osteotomy (group 2). The fixation was dynamic in three sheep with a transverse osteotomy (group 3) using a roller-bearing mechanism allowing 1 mm of axial displacement. The bone callus stiffness increased progressively with time. One month after osteotomy the load force through the fixator in groups 1 and 2 was more than 20%, whereas the equivalent load force in group 3 was only about 5%.Résumé Avec un fixateur monolatéral instrumenté avec des jauges extensiométriques (strain gauges) on a étudié l'évolution des forces qui passent par le fixateur et la rigidité du cal de fracture chez neuf agneaux ayant trois types d'ostéotomies du tibia et des fixations différentes (I: ostéotomie transversale avec fixation rigide; II: osté-otomie oblique avec fixation rigide; III: ostéotomie transversale avec fixation dynamique. La rigidité du cal de fracture augmente progressivement dans les trois groupes alors que les forces qui passent par le fixateur diminuent. Après un mois, chez tous les animaux ayant un traitement rigide (groupe I et II) les forces qui passent par le fixateur sont supérieures à 20%, alors que dans le groupe III, à la même période, les forces moment sont approximativement de 5%.

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Section: Discussionmentioning

confidence: 99%

Mechanical analysis of the healing of different osteotomies fixed externally

Mora

Forriol

2000

International Orthopaedics

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“…A rich body of literature documents the relationship between so-called primary bone healing (direct intramembranous bone formation) and secondary bone healing via a callus [Miclau et al 2005, Aro and Chao 1993, Stoffel et al 2000, where lack of stability is associated with formation of a callus, which then mineralizes via endochondral mechanisms. Interestingly, given sufficient mechanical stability, the periosteum alone is an efficient regenerator of bone in critical sized defects [Knothe Tate et al 2007, Knothe Tate unpublished data]; within a week, the periosteum fills the 4 cm diameter and 2.54 cm long defect with woven bone resembling trabeculae ( Figure 6) [Knothe Tate unpublished data].…”

Section: Mesenchymal Condensations In Postnatal Repair and Regeneratimentioning

confidence: 99%

Mechanical modulation of osteochondroprogenitor cell fate

Tate

Falls

McBride

et al. 2008

The International Journal of Biochemistry & Cell Biology

102

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Mesenchymal cells are natural tissue builders. They exhibit an extraordinary capacity to metamorphize into differentiated cells, using extrinsic spatial and temporal inputs and intrinsic algorithms, as well as to build and adapt their own habitat. In addition to providing a habitat for osteoprogenitor cells, tissues of the skeletal system provide mechanical support and protection for the multiple organs of vertebrate organisms. This review examines the role of mechanics on determination of cell fate during pre-, peri-and postnatal development of the skeleton as well as during tissue genesis and repair in postnatal life. The role of cell mechanics is examined and brought into context of intrinsic cues during mesenchymal condensation. Remarkable new insights regarding structure function relationships in mesenchymal stem cells, and their influence on determination of cell fate are integrated in the context of de novo tissue generation and postnatal repair. Key differences in the formation of osteogenic and chondrogenic condensations are discussed in relation to direct intramembranous and indirect endochondral ossification. New approaches are discussed to elucidate and exploit extrinsic cues to generate tissues in the laboratory and in the clinic.

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“…In addition, there was substantial interobserver variability regarding the scoring of radiographs and histologic slides. Finally, the type of fixation, use of interfragmentary compression across the transplant, allowance of weightbearing, and the end point of 90 days are variables that may have affected our overall assessment of union [4,6]. However, nonunions were detected in all experimental groups, suggesting that despite these variables, detectable nonunions do occur.…”

Section: Discussionmentioning

confidence: 99%

Effects of a New Allograft Processing Procedure on Graft Healing in a Canine Model: A Preliminary Study

Beebe

Benevenia

Tuy

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Graft healing in vivo can be affected by allograft processing. We asked whether a new processing technique influenced graft-host healing compared with autograft and a standard processing technique in a canine ulna model. We used bilateral intercalary allografts or autografts in the ulna of 13 skeletally mature male coonhounds. Each animal received two allografts, either one autograft and one allograft, or two autografts. At term (90 days), the graft sites were harvested. We assessed union with high-resolution xray imaging. Each specimen was processed for nondecalcified histologic analysis to assess the graft-host interface. Quantitative histomorphometric analysis was performed to determine spatial location and area of bone. Radiographic analysis, histologic analysis, and histomorphometric measures revealed no differences in union, mean total bone area, or total endosteal/intramedullary bone for the new process, standard process, and autografts. Our preliminary data suggest the new processing techniques may increase the safety of allograft transplantation without adversely affecting union when compared with standard processing techniques and autograft in a canine model.

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Bone-Healing Patterns Affected by Loading, Fracture Fragment Stability, Fracture Type, and Fracture Site Compression

Cited by 146 publications

References 0 publications

Mechanical analysis of the healing of different osteotomies fixed externally

Mechanical analysis of the healing of different osteotomies fixed externally

Mechanical modulation of osteochondroprogenitor cell fate

Effects of a New Allograft Processing Procedure on Graft Healing in a Canine Model: A Preliminary Study

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