Bone-Healing Pattern on the Surface of Titanium Implants at Cortical and Marrow Compartments in Two Topographic Sites: an Experimental Study in Rabbits

Abstract

This study evaluates the bone-healing patterns on the surface of titanium implants at the cortical and marrow compartments of bicortically-installed implants in the diaphysis and metaphysis of rabbit tibiae. In 27 New Zealand rabbits, two implants, one for each macro-design and with equal resorbable blasted media (RBM) implant surfaces, were randomly implanted in the diaphysis or metaphysis of each tibia. The flaps were sutured to allow submerged healing. The animals were sacrificed after two, four, or eight weeks, with nine weeks used for the period of healing. Ground sections were prepared and analyzed. No statistically significant differences were found between the two groups for newly formed bone in contact with the implant surface after two, four, and eight weeks of healing. Bone apposition in the marrow compartment was slightly higher in the diaphysis compared to metaphysis regions across healing stages. Despite the limitations of the present study, it can be concluded that new bone apposition was better than average in the cortical compartment as compared to the marrow compartments. Bone morphometry and density may affect bone apposition onto the implant surface. The apposition rates were slightly better at both the cortical and marrow compartments in diaphysis as compared to metaphysis sites. The new bone formation at the marrow compartment showed slightly better increasing values at diaphysis compared to metaphysis implantation sites.

Dental Pulp Stem Cells on Implant Surface: An In Vitro Study

“…In particular, the key protein for bone tissue formation, the osteocalcin was already produced and released to be bound to ECM for mineralization. Also, the vasculogenesis process was carried out by cell-Myth (Maipek Manufacturer Industrial Care, Naples, Italy) devices, even if in a later stage with respect to the control [45][46][47][48][49][50][51][52][53][54][55][56][57].…”

Impact of Different Titanium Implant Thread Designs on Bone Healing: A Biomechanical and Histometric Study with an Animal Model

“…al. [27]. However, the abundant presence of osteogenic tissue throughout the chamber area and closer interaction with the implant surface observed for the two-month period possibly resulted in the significantly higher degrees of BAFO%, ratifying a previous animal study that showed that surface wettability is beneficial in hastening osseointegration in healing chambers at early periods [28].…”

Sandblasted and Acid Etched Titanium Dental Implant Surfaces Systematic Review and Confocal Microscopy Evaluation

“…In this case the turns of the dental implant with different dimensions, number and pitch may be affected. Coils may be present or not [30,31,32,33,34,35,36,37,38,39,40]. The function of the loops is to efficiently distribute the masticatory load and to guarantee stability in the early post-surgical phases of the implant [41,42,43].…”