Bone grafts and periodontal regeneration

Histological and Histomorphometric Study of the Effect of Strontium Ranelate on the Healing of One-Wall Intrabony Periodontal Defects in Dogs

“…Since histological evaluation remains the only reliable method to determine the efficacy of periodontal therapies [19], therefore, the present study was employed in an attempt to evaluate the healing of surgically created intrabony periodontal defects in dogs after treatment with strontium ranelate 2% gel in a collagen sponge histological and histomorphometrically.…”

Clinical Comparison of an Enamel Matrix Derivative Used Alone or in Combination With a Bovine‐Derived Xenograft for the Treatment of Periodontal Osseous Defects in Humans

“…51 According to a literature review article, the mean amount of bone fill of the original defect is about 60% when using any bone replacement graft material. 52 The combination of bone replacement graft materials has been documented to show equal or superior results when compared to non-combined materials. 41,53 In a reentry study, the performance of an anorganic bovinederived hydroxyapatite bone matrix (ABM) alone and combined with a synthetic cell binding peptide, P-15 (ABM + P-15) was reported.…”

“…It has also been speculated that the superior outcome of the combined approach is due to enhanced blood clot stabilization and isolation of the gingival epithelial and connective tissue cells from the defect area. 52 Reentry surgery to assess bone fill does not distinguish between bone that is attached to the root surface via junctional epithelium or periodontal ligament. Histological evaluation remains the only reliable method to determine the components of the new attachment apparatus and allows for distinction between repair and regeneration.…”

Bone Substitute Materials in Modern Dentistry

“…Allotransplants are the transplants that are harvested from the same species individ (genotypes of donor and recipient are different) (13,14,23) . Donors can be relatives, non-relatives, and even corpses.…”