Bone grafting: Role of histocompatibility in transplantation

Goldberg, Victor M.; Powell, Arnold E.; Shaffer, John W.; Zika, Jocelyn M.; Bos, Gary D.; Heiple, Kingsbury G.

doi:10.1002/jor.1100030401

Cited by 151 publications

(84 citation statements)

References 35 publications

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“…counterparts with regard to bone induction properties, revascularization, and incorporation into host bone (Goldberg et al 1985, Wilson et al 1985, Burchardt 1987. Clinical matching of transplantation antigens between donor and host has not given a definite answer as to whether allograft inferiority is due to immunologic incompatibility (Friedlaender 1983, Burwell et al 1985, although experimental evidence suggests that this is the case (Bos et al 1983, Goldberg et al 1985.…”

Section: Methodsmentioning

confidence: 99%

“…Clinical matching of transplantation antigens between donor and host has not given a definite answer as to whether allograft inferiority is due to immunologic incompatibility (Friedlaender 1983, Burwell et al 1985, although experimental evidence suggests that this is the case (Bos et al 1983, Goldberg et al 1985. Analogous to cell-mediated mechanisms in skin-graft rejection, T-lymphocyte immune responses might be important for the revascularization and incorporation of allogeneic bone grafts.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Bone grafts in T-cell deficient rats

Kirkeby

Larsen

Lereim

1991

Acta Orthopaedica Scandinavica

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Bone grafts in T-cell deficient rats

Kirkeby

Larsen

Lereim

1991

Acta Orthopaedica Scandinavica

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“…Standards of measurement were chosen based on a consensus among three orthopaedic surgeons, who constituted a consensus development panel. As a result, three indices of the Goldberg scoring system were chosen [13]. On lateral foot radiographs, the first index is evaluation of graft appearance, which receives a score of 0 for resorbed, 1 for mostly resorbed, 2 for largely intact, and 3 for reorganizing.…”

Section: Consensus-building Of Radiographic Measurementsmentioning

confidence: 99%

Incidence and Risk Factors of Allograft Bone Failure After Calcaneal Lengthening

Lee

Chung

Lee

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Calcaneal lengthening with allograft is frequently used for the treatment of patients with symptomatic planovalgus deformity; however, the behavior of allograft bone after calcaneal lengthening and the risk factors for graft failure are not well documented. Questions/purposes (1) What proportion of the patients treated with allograft bone had radiographic evidence of graft failure and what further procedures were performed? (2) What are the risk factors for radiographic graft failure after calcaneal lengthening? (3) What patient factors are associated with the magnitude of correction achieved after calcaneal lengthening? Methods Between May 2003 and January 2014, we performed 341 calcaneal lengthenings on 202 patients for planovalgus deformity, the etiology of which included idiopathic, cerebral palsy, and other neuromuscular disease. Of these, 176 patients (87%) had adequate followup for graft evaluation, defined as lateral radiographs taken before and at least 6 months after the index procedure (mean, 18 months; range, 6-100 months) and 117 patients (58%) had adequate followup for the assessment of the extent of correction, defined as weightbearing anteroposterior and lateral radiographs taken before and at least 1 year after the index procedure (mean, 24 months; range, 12-96 months). These patients' results were evaluated retrospectively. The Goldberg scoring system was chosen for demonstration of allograft behavior. A score lower than 6 at 6 months after surgery was defined as radiographic graft failure; the highest possible score was 7 points, and this represented graft incorporation with excellent reorganization of the graft and no loss of height. The patient age, sex, diagnosis, graft material, ambulatory status, and use of antiseizure medication were evaluated as possible risk factors, and we controlled for the interaction of potentially confounding variables using multivariate analysis. Additionally, six radiographic indices were analyzed for their effects on the extent of correction. Results The mean estimated Goldberg score was 6 (SD, 1.14) at 6 months after calcaneal lengthening with 11 feet (4%) classified as radiographic graft failure (Goldberg score \ 6). Of these, four feet (1%) underwent reoperation using an iliac autograft bone resulting from pain and loss of correction. Multivariate analysis showed that the tricortical iliac crest allograft was superior to the patellar allograft (odds ratio [OR], 3.2; 95% confidence interval [CI], 1.1-9.8; p = 0.038) and the possibility of radiographic graft failure was found to increase along with age (OR, 1.2; 95% CI, 1.0-1.3; p = 0.006). Radiographically, the extent of correction was found to decrease with patient age, as

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“…Fracture healing was analysed by two observers, without knowledge of the treatments, according to the classification of Goldberg et al (Goldberg et al, 1985) with stage 0 indicating radiological non-union, stage 1 indicating possible union and stage 2 indicating radiological union. Callus diameter was measured in relation to the femur diameter (%) (ImageJ Analysis System, NIH, Bethesda, MD, USA).…”

Section: Radiological Analysismentioning

confidence: 99%

Inhibition of angiotensin‐converting enzyme stimulates fracture healing and periosteal callus formation – role of a local renin‐angiotensin system

Garcia

Schwenzer

Slotta

et al. 2010

British J Pharmacology

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Background and purpose:The renin-angiotensin system (RAS) regulates blood pressure and electrolyte homeostasis. In addition, 'local' tissue-specific RAS have been identified, regulating regeneration, cell growth, apoptosis, inflammation and angiogenesis. Although components of the RAS are expressed in osteoblasts and osteoclasts, a local RAS in bone has not yet been described and there is no information on whether the RAS is involved in fracture healing. Therefore, we studied the expression and function of the key RAS component, angiotensin-converting enzyme (ACE), during fracture healing. Experimental approach: In a murine femur fracture model, animals were treated with the ACE inhibitor perindopril or vehicle only. Fracture healing was analysed after 2, 5 and 10 weeks using X-ray, micro-CT, histomorphometry, immunohistochemistry, Western blotting and biomechanical testing. Key results: ACE was expressed in osteoblasts and hypertrophic chondrocytes in the periosteal callus during fracture healing, accompanied by expression of the angiotensin type-1 and type-2 receptors. Perindopril treatment reduced blood pressure and bone mineral density in unfractured femora. However, it improved periosteal callus formation, bone bridging of the fracture gap and torsional stiffness. ACE inhibition did not affect cell proliferation, but reduced apoptotic cell death. After 10 week treatment, a smaller callus diameter and bone volume after perindopril treatment indicated an advanced stage of bone remodelling. Conclusions: Our study provides evidence for a local RAS in bone that influenced the process of fracture healing. We show for the first time that inhibition of ACE is capable of accelerating bone healing and remodelling.

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Bone grafting: Role of histocompatibility in transplantation

Cited by 151 publications

References 35 publications

Bone grafts in T-cell deficient rats

Bone grafts in T-cell deficient rats

Incidence and Risk Factors of Allograft Bone Failure After Calcaneal Lengthening

Inhibition of angiotensin‐converting enzyme stimulates fracture healing and periosteal callus formation – role of a local renin‐angiotensin system

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