Bone grafting options for lumbar spine surgery: a review examining clinical efficacy and complications

Vaz, Kenneth; Verma, Kushagra; Protopsaltis, Themistocles S.; Schwab, Frank J.; Lonner, Baron S.; Errico, Thomas J.

doi:10.1016/j.esas.2010.01.004

Cited by 40 publications

(31 citation statements)

References 103 publications

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“…Moreover, the second surgery for removing the titanium-based cervical plate was not a major one. IBG was preferred to use as it has been considered as the gold standard, 15 and, moreover, a dedicated titanium-based graft for children is not yet available. The posterior approach would require the use of more implants and few physiological surgical procedures related to the removal of some vertebral laminae, and the pressing material itself was located in the anterior of the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Anterior cervical corpectomy and fusion in a 7-year-old boy: a case report

Saekhu¹,

Ashari²,

Tandian³

et al. 2019

Med J Indones

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Bicycle mishap, a common and ordinary event occurring in children, can have devastating consequences associated with cervical spine injury. Furthermore, either diagnosis or surgical management of cervical spine injury in children is a challenging issue. This research report a challenging case of an anterior cervical corpectomy and fusion with plating in a 7-year-old boy due to cervical spine instability with spinal cord compression after a bicycle mishap. After 20 months of the primary surgery, the titanium-based cervical plate was removed by a second surgery to allow the growth of the cervical spine.

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Section: Discussionmentioning

confidence: 99%

Anterior cervical corpectomy and fusion in a 7-year-old boy: a case report

Saekhu¹,

Ashari²,

Tandian³

et al. 2019

Med J Indones

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“…Bone graft materials can be used as stand-alones or supplement other grafts or synthetic cages [10][11][12][13][14] . Such materials include graft enhancers, which strengthen the fusion mass, and graft extenders, which help achieve fusion with a reduced primary graft component 15 .…”

Section: Introductionmentioning

confidence: 99%

Bone Graft Substitutes for Anterior Lumbar Interbody Fusion

Mobbs

Chung

Rao

2013

Orthopaedic Surgery

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The procedure of anterior lumbar interbody fusion (ALIF) is commonly performed on patients suffering from pain and/or neurological symptoms associated with disorders of the lumbar spine caused by disc degeneration and trauma. Surgery is indicated when prolonged conservative management proves ineffective. Because an important objective of the ALIF procedure is solid arthrodesis of the degenerative spinal segment, bone graft selection is critical. Iliac crest bone grafts (ICBG) remain the "gold standard" for achieving lumbar fusion. However, patient dissatisfaction stemming from donor site morbidity, lengthier operating times and finite supply of ICBG has prompted a search for better alternatives. Here presented is a literature review evaluating available bone graft options assessed within the clinical setting. These options include autografts, allograft-based, synthetic and cell-based technologies. The emphasis is on the contentious use of recombinant human bone morphogenetic proteins, which is in widespread use and has demonstrated both significant osteogenic potential and risk of complications.

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“…22 A BGS material with the strength of cortical bone will benefit many patients and be particularly useful in spinal arthrodesis where high strength and osteoinductivity are essential to ensure rapid fusion. 23,24 A structural BGS should match the mechanical properties of native bone and remain stable once implanted, that is, not expand or contract thereby affecting bony integration. 25 There is a large variation in the reported properties of native bone due to its anisotropy, person-toperson variation, use of aged or osteoporotic bone and the anatomical location of the tested specimen.…”

Section: Introductionmentioning

confidence: 99%

High-strength scaffolds for bone regeneration

Meredith

Mallick

2015

Bioinspired, Biomimetic and Nanobiomaterials

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Repair of large skeletal defects that are intrinsic to skeletal stability represents the greatest challenge for orthopaedic surgeons. IntroductionBone defects arising from disease, trauma, infection or genetic abnormality are reconstructed with non-biodegradable materials such as stainless steel or titanium to restore skeletal function. 2,3These materials have been associated with long-term problems such as loosening, 4 peri-prosthetic fracture and infection. 5The modern approach is marked by a shift in emphasis from replacement to regeneration of tissue. 6,7 This is achieved by way of human-or animal-derived grafts (autograft, allograft or xenograft), bone graft substitute (BGS) materials, growth factors 8 or bioinorganics. 9 The drawbacks associated with human-and animal-derived grafts such as limited availability, high cost, poor remodelling, donor site morbidity, delayed healing and disease transmission have driven extensive research into synthetic alternatives. [10][11][12][13] The principal advantages of BGSs are unlimited supply, ease of sterilisation and storage, predictable mechanical properties, excellent bone in-growth and moderate cost. 14,15 Bone defects can be categorised into those that are intrinsic to skeletal stability and those that are not. Currently, there are numerous commercially available low-strength, void-filling BGS products but none are indicated to offer structural support to the skeleton. [16][17][18] Thus, there is an urgent need for BGSs that can replace allogenous or autogenous grafts in large defects, for example, in resections for infection or tumour. In these instances, bone grafts can be as large as 20 cm and their locations (joints, spine and long bones) require them to bear load and function with instrumentation to maintain the stability of the skeleton.2,19-21 Non-structural biomaterials can repair segmental defects in combination with instrumentation such as plates and screws but these require an additional retrieval procedure.22 A BGS material with the strength of cortical bone will benefit many patients and be particularly useful in spinal arthrodesis where high strength and osteoinductivity are essential to ensure rapid fusion. 23,24High-strength scaffolds for bone regeneration Meredith and Mallick

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Bone grafting options for lumbar spine surgery: a review examining clinical efficacy and complications

Cited by 40 publications

References 103 publications

Anterior cervical corpectomy and fusion in a 7-year-old boy: a case report

Anterior cervical corpectomy and fusion in a 7-year-old boy: a case report

Bone Graft Substitutes for Anterior Lumbar Interbody Fusion

High-strength scaffolds for bone regeneration

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