Bone Graft Substitutes: Current Uses in Hand Surgery

Patel, Milan M.; Catalano, Louis W.

doi:10.1016/j.jhsa.2009.01.019

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Those problems motivated the development of biomaterials to be used as synthetic scaffolds that must simulate the bone physicochemical environment and suffer degradation after complete their function of anchoring the new bone without, however, liberate toxic substances in the host organism 2 . In addition, preferentially, these materials have to be osteoinductors or have to induce bone formation and to be osteoconductor or have to allow the bone ingrowths [4][5][6] . In order to stimulate the bone growths in porous and biodegradable scaffolds, they have been cultivated by stem cells, so the tridimensional graft promotes a fundamental anchorage to cellular adhesion, proliferation and differentiation in osteoblasts 7 .…”

Section: Introductionmentioning

confidence: 99%

Osteoinduction test of anorthite by human mesenchymal stem cell culture

Sousa

Fernandes²,

Rebelatto

et al. 2012

Mat. Res.

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In this work, adult stem cells of three volunteers were isolated, expanded and cultivated over samples of Anorthite in order to assess its osteoinductive capacity. Alkaline Phosphatase Analysis, ALP, was carried out at days 1, 7, 14 and 21, and the results showed similar behavior between the volunteers considering the initial value of each. For volunteer 1, between day 14 and 21, the decreasing of ALP was remarkable in the wells containing MSC only and MSC+BIO, from 59.9 to 26.3 U.L , respectively, suggesting that the biomaterial was able to induce osteoblast formations. This osteoinduction property could be evidenced by Citochemistry where MSCs did not produce crystals of Calcium Oxalate or Calcium Phosphate, osteoblast compounds, without being stimulated by a chemical inducer, lending to the conclusion that the differentiation of MSC into osteoblast when cultivated on Anorthite, occurred exclusively by its influence, strongly suggesting that it is osteoinductive.

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Section: Introductionmentioning

confidence: 99%

Osteoinduction test of anorthite by human mesenchymal stem cell culture

Sousa

Fernandes²,

Rebelatto

et al. 2012

Mat. Res.

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“…1 Bone graft substitutes (BGSs) are synthetic biomaterials that have been engineered to avoid the need for additional operative sites, reduce operative time, and mitigate the potential for disease transmission, immunogenicity, and donor-site complication. 2 The BGS market was valued at $2.4 billion in 2015 and has been estimated to nearly double in the ensuing decade; currently over 100 products are clinically available.…”

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confidence: 99%

Bone Graft Substitutes: Current Concepts and Future Expectations

Lobb

DeGeorge

Chhabra

2019

The Journal of Hand Surgery

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Owing to its osteoinductive and osteoconductive properties and the presence of osteogenic cells, freshly harvested autologous bone graft is the gold standard for skeletal reconstruction where there is inadequate native bone. Whereas these characteristics are difficult to replicate, engineered, commercially available bone graft substitutes aim to achieve a comparable osseoregenerative profile. This work furnishes the reader with an understanding of the predominant classes of bone graft substitutes available for reconstruction of upper extremity CME INFORMATION AND DISCLOSURESThe Journal of Hand Surgery will contain at least 2 clinically relevant articles selected by the editor to be offered for CME in each issue. For CME credit, the participant must read the articles in print or online and correctly answer all related questions through an online examination. The questions on the test are designed to make the reader think and will occasionally require the reader to go back and scrutinize the article for details.The JHS CME Activity fee of $15.00 includes the exam questions/answers only and does not include access to the JHS articles referenced.Statement of Need: This CME activity was developed by the JHS editors as a convenient education tool to help increase or affirm reader's knowledge. The overall goal of the activity is for participants to evaluate the appropriateness of clinical data and apply it to their practice and the provision of patient care. Accreditation:The American Society for Surgery of the Hand (ASSH) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.AMA PRA Credit Designation: The ASSH designates this Journal-Based CME activity for a maximum of 1.00 AMA PRA Category 1 Creditsä. Physicians should claim only the credit commensurate with the extent of their participation in the activity.ASSH Disclaimer: The material presented in this CME activity is made available by the ASSH for educational purposes only. This material is not intended to represent the only methods or the best procedures appropriate for the medical situation(s) discussed, but rather it is intended to present an approach, view, statement, or opinion of the authors that may be helpful, or of interest, to other practitioners. Examinees agree to participate in this medical education activity, sponsored by the ASSH, with full knowledge and awareness that they waive any claim they may have against the ASSH for reliance on any information presented. The approval of the US Food and Drug Administration (FDA) is required for procedures and drugs that are considered experimental. Instrumentation systems discussed or reviewed during this educational activity may not yet have received FDA approval.

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