Bone-Graft Reconstruction of the Monkey Orbital Floor with Iliac Grafts and Titanium Mesh Plates

Sullivan, Patrick K.; Rosenstein, David A.; Holmes, Ralph E.; Craig, David M.; Manson, Paul N.

doi:10.1097/00006534-199304001-00002

Cited by 38 publications

(7 citation statements)

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“…Sullivan et al 24 showed in an animal study that resorption of approximately one-third of bone-graft thickness and width had taken place during a 28-week interval for reconstruction of orbital floor defects with iliac crest bone grafts. Further- more, they found a similar resorption rate for those grafts that spanned the orbital defect and those that were supported by a titanium plate.…”

Section: Discussionmentioning

confidence: 99%

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

et al. 2003

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Alloplastic materials offer a number of advantages over bone autografts in the reconstruction of craniofacial defects. These include: lack of donor site morbidity, unlimited quantities of available material, and the possibility to conform exactly to the defect. An ideal bioresorbable material would degrade slowly, and have osteoconductive properties to allow replacement and remodeling by osseous tissue. This is seldom observed, the materials instead being replaced by fibrous tissue. Polycaprolactone (PCL), an FDA-approved bioresorbable polymer, has several properties that might make it suitable for reconstruction of craniofacial defects. The technique of fused deposition modeling (FDM) allows for the fabrication of highly reproducible bioresorbable 3D scaffolds. The nature of the fully interconnected pore network might enhance vascular ingrowth and osteoconductive properties. It was hypothesized that coating the scaffolds in bone marrow might enhance bone formation due to the osteoinductive nature of the bone-marrow mesenchymal cells. This study aimed to test these hypotheses in the pig model. Defects measuring 2 x 2 cm were surgically created in each orbit of eight Yorkshire pigs. The orbits were divided into three groups: Group 1 (n=4), no reconstruction (control); Group 2 (n=6), reconstruction with no coated PCL scaffolds; and Group 3 (n=6) reconstruction with bone-marrow-coated PCL scaffolds. The results were evaluated at 3 months by histological and histomorphometric analyses. The defects in Group 1 were covered with fibrous scar tissue. The shape of the reconstructed area was insufficient. The defects in Groups 2 and 3 were reconstructed correctly. In Group 2 the noncoated scaffolds showed 4.5% of new bone formation compared with 14.1% in Group 3, which is statistically significant (p<0.05). The entirely interconnected 3D polycaprolactone scaffold seems to be a promising material. It induces the bone ingrowth required for reconstructing craniofacial and orbital defects. Further long-term evaluations of these PCL scaffolds must be made in order to confirm these conclusions.

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Section: Discussionmentioning

confidence: 99%

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

et al. 2003

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“…A disadvantage of iliac bone graft lies in the problems of bone resorption and donor-site complications. The iliac crest graft is said to be bulky without trimming and it may resorb unpredictably 9…”

Section: Discussionmentioning

confidence: 99%

In Situ Splitting of a Rib Bone Graft for Reconstruction of Orbital Floor and Medial Wall

Uemura

Yanai

Yasuta

et al. 2017

Craniomaxillofacial Trauma & Reconstruction

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In situ splitting of rib bone graft was conducted in 22 patients for the repair of orbital fracture with no other complicating fractures. A bone graft was harvested from the sixth or seventh rib in the right side. The repair of the orbital floor and medial wall was successful in all the cases. Ten patients had bone grafting to the orbital floor, eight had it done onto medial wall, and 4 onto both floor and wall after reduction. The mean length of in situ rib bone graft was 40.9 mm (range, 20-70 mm), the mean width of these was 14.9 mm (range, 8-20 mm). The bone grafting was done by one leaf for 15 cases and two leafs for 7 cases in size of defects. The technique of in situ splitting of a rib bone graft for the repair of the orbital floor and medial wall is a simple and safe procedure, easily taking out the in situ splitting of a rib, and less pain in donor site. It has proved to be an optimal choice in craniofacial reconstruction, especially the defects of orbital floor and medial wall.

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“…Donor sites include the split calvarial bone graft, rib, maxillary wall, mandibular symphysis, iliac crest, antral bone and coronoid process (1,(5)(6)(7)(8)(9)(10)(11). The grafts can be placed as onlay grafts (12), fixated with a plate and screw (13), fixated with a lag screw or fixated in conjunction with an alloplastic material, such as titanium mesh or porous polyethylene sheets (14,15) (Figures 1-5).…”

Section: Autologous Materialsmentioning

confidence: 99%

“…Another method to decrease graft resorption is via rigid fixation of the graft (13,17,18), which likely facilitates ingrowth of the surrounding tissue and accelerates vascularization. The question of whether the use of a titanium mesh plate with a bone graft would increase graft resorption was answered with a histometric study (15) that showed no difference in the resorption of grafts with or without titanium mesh.…”

Section: Autologous Materialsmentioning

confidence: 99%

A review of materials currently used in orbital floor reconstruction

Mok¹

2004

J Plast Surg

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Orbital fractures are common fractures of the midface. As such, numerous techniques and materials exist for the repair of this region, each with inherent advantages and disadvantages. But does the ideal implant material exist? Should we stop and simply use readily available materials, or should the cycle of need and discovery continue? A comprehensive review of materials used in orbital reconstruction and possible new directions in orbital floor reconstruction are presented.

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Bone-Graft Reconstruction of the Monkey Orbital Floor with Iliac Grafts and Titanium Mesh Plates

Cited by 38 publications

References 0 publications

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

In Situ Splitting of a Rib Bone Graft for Reconstruction of Orbital Floor and Medial Wall

A review of materials currently used in orbital floor reconstruction

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