Journal of Oral and Maxillofacial Surgery

2002

DOI: 10.1053/joms.2002.34991

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Bone graft in the shape of human mandibular condyle reconstruction via seeding marrow-derived osteoblasts into porous coral in a nude mice model

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кораллы как остеопластический материал1

Tissue Engineering Session1

-Técnicas De Preparo De Escafoldes Cerâmicos1

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Cited by 77 publications

(57 citation statements)

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“…These studies approved possibility of use natural coral scaffold because of its biocompatibility, osteoconductivity and absorbability at a rate commensurate with bone formation. In addition, coral has cross-linked 3-dimensional pores with physical characteristic meets most requirements for a cell-seeding scaffold [20] . Further, more, it could easy be shaped into the required shape and size.…”

Section: Discussionmentioning

confidence: 99%

Growth of Bone Marrow Derived Osteoblast-Like Cells into Coral Implant Scaffold: Preliminary Study on Malaysian Coral

2009

American J. of Biochemistry and Biotechnology

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Problem statement: Biomaterial fabrication in Malaysia started as a consequence of the demand for cheaper implant materials. Various biomaterials have been developed utilizing local resources like Malaysian coral. Locally processed Malaysian coral need to be complemented with proper evaluation and testing including toxicology, biocompatibility, mechanical properties, physicochemical characterization and in vivo testing. The present study was carried out to assess natural coral of porites species as scaffold combined with in vitro expanded Bone Marrow Derived Osteoblast-Like cells (BM-DOL), in order to develop a tissue-engineered bone graft in a rat model. Approach: Coral was used in a block shape with a dimension of 10 mm length × 5 mm width × 5 mm thickness. BM-DOL cells were seeded into porous coral scaffold in a density of 5×10 6 mL −1 . After 7 days of in vitro incubation in osteogenic medium, one block was processed for light (LM) and Scanning Electron Microscopy (SEM) observations while the other blocks were implanted subcutaneously in the back of 5 weeks-old Sprague-Dawely rats for 3 months. Coral blocks without cells were implanted as a control. The implants harvested and processed for gross inspection, histological and scanning electron microscopy observations. Results: Both LM and SEM showed attachment of well arrangement multilayer cells inside the pores of in vitro seeded coral scaffolds. Gross inspection of all in vivo coral-cell complexes implants revealed vascularized like bone tissue formation. Histological sections revealed mature bone formation occurred in the manner resemble intramembraneous bone formation. SEM observations revealed multi-layer cellular proliferation with abundant collagen covered the surface of coral implants. Control group showed resorbed coral block. Conclusion:This study demonstrated that Malaysian coral can be use as a suitable scaffold material for delivering bone marrow mesenchymal stem cells in tissue engineering and therefore, offers a great potential to enhance bone healing around implants in a compromised bone bed.

“…These studies approved possibility of use natural coral scaffold because of its biocompatibility, osteoconductivity and absorbability at a rate commensurate with bone formation. In addition, coral has cross-linked 3-dimensional pores with physical characteristic meets most requirements for a cell-seeding scaffold [20] . Further, more, it could easy be shaped into the required shape and size.…”

Section: Discussionmentioning

confidence: 99%

Growth of Bone Marrow Derived Osteoblast-Like Cells into Coral Implant Scaffold: Preliminary Study on Malaysian Coral

2009

American J. of Biochemistry and Biotechnology

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Problem statement: Biomaterial fabrication in Malaysia started as a consequence of the demand for cheaper implant materials. Various biomaterials have been developed utilizing local resources like Malaysian coral. Locally processed Malaysian coral need to be complemented with proper evaluation and testing including toxicology, biocompatibility, mechanical properties, physicochemical characterization and in vivo testing. The present study was carried out to assess natural coral of porites species as scaffold combined with in vitro expanded Bone Marrow Derived Osteoblast-Like cells (BM-DOL), in order to develop a tissue-engineered bone graft in a rat model. Approach: Coral was used in a block shape with a dimension of 10 mm length × 5 mm width × 5 mm thickness. BM-DOL cells were seeded into porous coral scaffold in a density of 5×10 6 mL −1 . After 7 days of in vitro incubation in osteogenic medium, one block was processed for light (LM) and Scanning Electron Microscopy (SEM) observations while the other blocks were implanted subcutaneously in the back of 5 weeks-old Sprague-Dawely rats for 3 months. Coral blocks without cells were implanted as a control. The implants harvested and processed for gross inspection, histological and scanning electron microscopy observations. Results: Both LM and SEM showed attachment of well arrangement multilayer cells inside the pores of in vitro seeded coral scaffolds. Gross inspection of all in vivo coral-cell complexes implants revealed vascularized like bone tissue formation. Histological sections revealed mature bone formation occurred in the manner resemble intramembraneous bone formation. SEM observations revealed multi-layer cellular proliferation with abundant collagen covered the surface of coral implants. Control group showed resorbed coral block. Conclusion:This study demonstrated that Malaysian coral can be use as a suitable scaffold material for delivering bone marrow mesenchymal stem cells in tissue engineering and therefore, offers a great potential to enhance bone healing around implants in a compromised bone bed.

“…Имплантация одного лишь коралла использовалась в ка-честве контроля. Исследование показало, что вновь полу-ченные тканевые образцы представляли собой кость, име-ющую форму головки НС человека [24].…”

Section: кораллы как остеопластический материалunclassified

State and perspectives of studies on osteoplastic materials

2016

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1 Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии Минздрава россии, Москва; 2 российская медицинская академия последипломного образования Минздрава россии, Москва Освещены состояние и основные направления исследований по проблеме остеопластических материалов, используемых для замещения костных дефектов. Приведены типы этих материалов, эффекты и механизмы их взаимодействия с реципиентными тканями. Определены задачи и перспективы дальнейших исследований по проблеме. Разработка материалов, которые позволили бы ис-ключить необходимость использования аутогенной кости для замещения костных дефектов, признана одной из ак-туальнейших проблем теоретических и клинических ис-следований в травматологии и ортопедии, а также в че-люстно-лицевой хирургии [1,7].Прежде чем продолжить, мы сочли полезным вкратце остановиться на чрезвычайно важном для темы нашего обзора понятии биосовместимости. Термины «биологиче-ская индивидуальность организмов» и «биосовмести-мость» были введены французским ученым, нобелевским лауреатом по физиологии и медицине Алексисом Карре-лем (Alexis Carrel) в начале XX столетия. Он писал, что «животный организм защищается от чужеродных тканей (и инородных тел) при помощи той же самой реакции, ко-торая служит ему для борьбы с инфекцией». А. Каррель описал основные признаки реакции отторжения: отек, гиперемию, воспаление и некроз [46]. Эти фундаменталь-ные признаки и сегодня остаются основой для оценки биосовместимости имплантата, с одной стороны, и орга-низма-реципиента -с другой [46].Для оценки степени биосовместимости позже была предложена градация ее уровней, которые корреспонди-руют с характером и выраженностью реакций тканевых структур в области интерфейса [31]. Объективность таких оценок достигается на основе принципов доказательной медицины [56].Биотолерантные материалы. Кость контактирует с этими материалами без выраженных конфликтных реак-ций. Обычно в области контакта формируется фиброзная капсула; примером таких материалов могут служить поли-акрилаты либо сульфат кальция (гипс) [18,31,41].Биоинертные материалы. Контакт между материалом и костью может быть прямым, без образования фиброз-ной прослойки; однако новообразования нового костного вещества не наблюдается. Примером служит остеоинте-грация титановых дентальных имплантатов [11].Биоактивные материалы. В области контакта с остео-пластическим материалом обычно наблюдается исчезно-вение видимой границы (границы остеокоалесценции). Между материалом и костью происходит активный обмен веществами, материал, метаболизируясь, постепенно подвергается резорбции и замещается по мере резорбции вновь образованным костным веществом. Примеры таких материалов -карбонат кальция, некоторые фосфаты кальция или биостекло [9,29,31,34].Остеоиндуктивные материалы. Эти материалы актив-но вступают в обменные процессы в области интерфейса остеопластический материал -кость. В процессе метабо-лических взаимодействий с костью остеопластические

“…Although TMJ tissue engineering 27,37,104 is a relatively new field with only a handful of tissue engineering studies available for the TMJ disc [6][7][8][9][10]13,28,29,41,79,86,99 and mandibular condyle, [2][3][4][5]24,25,32,44,45,63,82,83,101,106,108 the number of researchers in the field is growing exponentially as investigators in related fields are discovering a new application for their existing orthopaedic tissue engineering strengths. With more researchers joining the TMJ tissue engineering effort, it is crucial that they are aware of TMJ-specific concerns and understand the pressing questions that exist today.…”

Section: Tissue Engineering Sessionmentioning

confidence: 99%

A Call to Action for Bioengineers and Dental Professionals: Directives for the Future of TMJ Bioengineering

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2007

Ann Biomed Eng

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Abstract-The world's first TMJ Bioengineering Conference was held May 25-27, 2006, in Broomfield, Colorado. Presentations were given by 34 invited speakers representing industry, academics, government agencies such as NIH, and private practice, which included surgeons, engineers, biomedical scientists, and patient advocacy leaders. Other attendees included documentary film makers and FDA officials. The impetus for the conference was that the field of TMJ research has been lacking continuity, with no open forum available for surgeons, scientists, and bioengineers to exchange scientific and clinical ideas and identify common goals, strengths, and capabilities. The goal was thus to plant the seeds for establishing a forum for multidisciplinary and interdisciplinary interactions. The collective wisdom and interactions brought about by a melting pot of these diverse individuals has been pooled and is disseminated in this article, which offers specific directives to bioengineers, basic scientists, and medical and dental professionals including oral and maxillofacial surgeons, pain specialists, orthodontists, prosthodontists, endocrinologists, rheumatologists, immunologists, radiologists, neurologists, and orthopaedic surgeons. A primary goal of this article was to attract researchers across a breadth of research areas to lend their expertise to a significant clinical problem with a dire need for new talent. For example, researchers with expertise in finite element modeling will find an extensive list of clinically significant problems. Specific suggestions for TMJ research were presented by the leading organizations for TMJ surgeons and TMJ patients, and further research needs were identified in a series of group discussions. The specific needs identified at the conference and presented here will be essential for those who endeavor to engage in TMJ research, especially in the areas of tissue engineering and biomechanics. Collectively, it is our hope that many of the questions and directives presented here find their way into the proposals of multidisciplinary teams across the world with new and promising approaches to diagnose, prevent and treat TMJ disorders.

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