Bone graft contamination from a water de-ionizer during processing in a bone bank

Farrington, M.; Matthews, I.; Foreman, James; Caffrey, Elizabeth

doi:10.1016/s0195-6701(96)90166-8

Cited by 15 publications

(6 citation statements)

References 4 publications

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“…Tissue allografts can also become contaminated during processing at the tissue bank from environmental surfaces, air, personnel, contaminated reagents, surgical instruments, supplies, and processing equipment (Table 4). Electrolyte solutions purchased commercially (Centers for Disease Control and Prevention 1995) or deionised water prepared by the tissue bank (Farrington et al 1996) can be contaminated by bacteria and contaminate the tissue allograft when used for processing. In rare cases, there has been contamination acquired during liquid nitrogen storage (Hawkins et al 1996).…”

Section: Reducing the Risk Of Bacterial Contamination During Tissue Pmentioning

confidence: 99%

Bacterial infection transmitted by human tissue allograft transplantation

Eastlund

2006

Cell Tissue Banking

122

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Bacterial contamination of tissue allografts obtained from cadaveric donors has been a serious cause of morbidity and mortality in recipients. Recent cases of fatal and nonfatal bacterial infections in recipients of contaminated articular cartilage (distal femur) and tendon allografts have called attention to the importance of avoiding tissue donors suspected of carrying infectious disease, of not processing donated tissue carrying virulent bacteria, the occurrence of falsely negative final sterility tests, and the need to sterilize tissues. These cases demonstrated that contamination can arise from an infected donor, during tissue removal from cadaveric donors, from the processing environment, and from contaminated supplies and reagents used during processing. Final sterility testing can be unreliable, especially when antibiotics remain on tissues. There is an increasing need for control of microbial contamination in tissue banks, and sterilization of tissue allografts should be recommended whenever possible.

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Section: Reducing the Risk Of Bacterial Contamination During Tissue Pmentioning

confidence: 99%

Bacterial infection transmitted by human tissue allograft transplantation

Eastlund

2006

Cell Tissue Banking

122

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“…Allogenic bone grafts obtained from tissue banks also have limitations because of the possible transmission of non-conventional agents or viruses and the risk of immunological incompatibility (Farrington et al, 1996;Marthy and Richter, 1998). Allogenic bone grafts have both osteoinductive properties (they release morphogenic bone proteins that act on bone cells) and osteoconductive properties, but lack osteogenic properties because of the absence of viable cells (Stevenson and Horowitz, 1992).…”

Section: Biomaterials Used As Bone Substitutesmentioning

confidence: 99%

A Review of Bioceramics and Fibrin Sealant

Guéhennec¹,

Layrolle²,

Daculsi³

2004

eCM

165

132

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This review focuses on bone substitute composites made by mixing ceramic biomaterials with fibrin sealants. Different biomaterials such as coral, bone-derived materials, bioactive glass ceramics, and synthetic calcium phosphate have been mixed with fibrin sealant, resulting in a combination of the biological properties of the two components. This type of association has not produced identical results in all studies. In the past for some, the addition of fibrin sealant to the biomaterial failed to produce any significant, positive effect on osteointegration, whereas others found a positive impact on bone colonization. Despite the negative biological effects reported previously, bioceramic-fibrin composites have been widely used in various types of bone surgery because they are easy to manipulate. In particular, the intra-operative preparation of these composites makes it possible to add bone growth factors or autologous osteoprogenitor cells prior to bone reconstruction. The bone growth factors and autologous osteoprogenitor cells associated with the bioceramic-fibrin composites should provide surgeons with tissue engineered grafts with enhanced osteointegrative properties. This review discusses both the advantages and disadvantages, as well as the future perspectives, of using bioceramic-fibrin composites in various clinical indications.

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“…Bacteria and fungi may be present within the musculoskeletal tissue at the time it was harvested or contaminated from exogenous sources. Exogenous contamination of musculoskeletal allografts may occur at the time of retrieval, processing or packaging from personnel, contaminated reagents and equipment, environmental surfaces and by aerosols …”

Section: Musculoskeletal Tissue Samplesmentioning

confidence: 99%

Bacteriology laboratories and musculoskeletal tissue banks in Australia

Varettas

2012

ANZ Journal of Surgery

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In Australia, there are six Therapeutic Goods Administration-licensed clinical bacteriology laboratories providing bacterial and fungal bioburden testing of allograft musculoskeletal samples sent from 10 tissue banks. Musculoskeletal swab and/or tissue biopsy samples are collected at the time of allograft retrieval and sent to bacteriology laboratories for bioburden testing, in some cases requiring interstate transport. Bacteria and fungi may be present within the allograft at the time of retrieval or contaminated from an external source. The type of organism recovered will determine if the allograft is rejected for transplant, which may include all allografts from the same donor. Bacteriology staff also provides unpaid support of tissue banks through meeting involvement, consultations, licence-related activities, validations and research funded by their organisation and not part of any contractual agreement. Bacteriology laboratories and tissue banks must be compliant to the Code of Good Manufacturing Practice - Human Blood and Tissues and regulated by the Therapeutic Goods Administration. Clinical bacteriology laboratories also require mandatory accreditation to Standards Australia International Organisation for Standardisation (ISO) 15189:2009 medical laboratories - particular requirements for quality and competence, and may also attain Standards Australia/New Zealand Standard ISO 9001:2000 quality management systems certification. Bacteriology laboratories and musculoskeletal tissue banks are integral partners in providing safe allograft musculoskeletal tissue for transplant.

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Bone graft contamination from a water de-ionizer during processing in a bone bank

Cited by 15 publications

References 4 publications

Bacterial infection transmitted by human tissue allograft transplantation

Bacterial infection transmitted by human tissue allograft transplantation

A Review of Bioceramics and Fibrin Sealant

Bacteriology laboratories and musculoskeletal tissue banks in Australia

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