Bone formation with various bone graft substitutes in critical‐sized rat calvarial defect

Park, Jin Woo; Jang, Jinho; Bae, Sang-Ryul; An, Chang-Hyeon; Suh, Jo‐Young

doi:10.1111/j.1600-0501.2008.01602.x

Cited by 57 publications

(56 citation statements)

References 32 publications

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“…The ability of Bio-Oss to facilitate bone regeneration has also been evaluated in numerous animal studies using criticalsize defects and domes 8,9,11,22,[25][26][27]30,35,36,[38][39][40][41]43,44,48 . Bone healing in the maxillary sinus, artificial defects, and domes may not be directly comparable but a number of similar characteristics have been observed.…”

Section: Discussionmentioning

confidence: 99%

Maxillary sinus floor augmentation with Bio-Oss or Bio-Oss mixed with autogenous bone as graft in animals: a systematic review

Jensen

Schou

Stavropoulos

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Maxillary sinus floor augmentation with Bio-Oss or Bio-Oss mixed with autogenous bone as graft in animals: a systematic review

Jensen

Schou

Stavropoulos

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…Sample size calculation was based on data from one study evaluating the effect of various bone substitute material in bone regeneration in CSD in rats, using a similar histomorphometric evaluation [33]. In this study, the minimum average difference in bone formation observed among the various biomaterials was 7.3%, with a standard deviation of…”

Section: Statisticsmentioning

confidence: 99%

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

et al. 2018

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Objective To evaluate the effect of grafting with strontium (Sr)-loaded deproteinized bovine bone (DBB) on bone healing in calvarial critical size defects (CSD) in rats. Material and methods Two circular bone defects (5 mm in diameter) were created in the calvaria of 42 rats. One of the defects, randomly chosen, was grafted with (a) DBB, (b) DBB loaded with 19.6 μg/g of Sr (DBB/Sr1), or (c) DBB loaded with 98.1 μg/g of Sr (DBB/Sr2). The other defect was left empty as negative control. Groups of seven animals from each of the groups were euthanized 15 and 60 days post-op. Bone healing in the CSD was evaluated by micro-CT and histology/histomorphometry and immunohistochemistry.Results DBB/Sr2-grafted sites showed statistically significantly shorter radiographic residual defect length compared with DBB/ Sr1-and DBB-grafted sites, and with empty controls at 60 days. Further, the amount of new bone formation in the DBB/Sr1-and DBB/Sr2-grafted sites was significantly higher compared with that in the DBB-grafted sites at 60 days. A larger number of DBB/ Sr1-and DBB/Sr2-grafted sites presented with no-or only limited to mild inflammation, compared with the DBB-grafted sites, especially at 60 days. Higher expression of osteocalcin was observed in DBB/Sr1-and DBB/Sr2-grafted sites as compared to DBB-grafted sites. Conclusion Grafting with Sr-loaded DBB enhanced bone formation in CSD in rats, when compared with grafting with nonloaded DBB. Clinical relevance Grafting with Sr-loaded DBB may enhance bone formation in bone defects.

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“…The Norian presented superior space maintaining abilities compared to ChronOs and BonePlast. The V v s of new bone were similar between the materials studied and comparable to the unfilled controls, described, for example, by Park et al (2009), and lower of the V v of Bio-oss, hydroxy apetite and calcium sulfate hydroxyl apetite filled defects in the same study, although the last were studied earlier, in week 12 [14]. This points that the described mod is feasible and promising, other new bone substitutes that can be injected need to be sought.…”

Section: Discussionmentioning

confidence: 64%

Minimally Invasive Subpericranial Model: Can It Be Used to Study Bone Substitutes?

Allon¹,

Allon²,

Anavi³

2013

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Objective: To evaluate the feasibility and effectiveness of a new approach for craniofacial augmentation by a minimally-invasive subpericranial injection. Three commercially available semi-liquid bioceramic bone-grafting materials were examined for this application in a rat model. Material and Methods: Twenty-four adult male rats were randomly assigned to undergo onlay calvarial grafting by subpericranial injection of three semi-liquid bone void fillers: Norian SRS ® (calcium phosphate), ChronOs Inject TM (porous beta-tricalcium phosphate), or BonePlast ® (calcium sulfate). Two rats in each group were harvested after 24 hours to serve as controls. The rest were studied after 16 weeks. The volume fraction of the following parameters was morphometrically measured: new bone, blood vessels, residual bone filler and inflammation. Results: In all study groups (including controls), histological examination demonstrated that bone fillers were successfully delivered to the desired subpericranial space by the percutaneous injection method. New bone formation was evidenced adjacent to the cranial bone in all the study groups. The Norian filler material survived in a significantly higher volume fraction (38.4% ± 6.5%) than the ChronOs filler (18.8% ± 1.6%; P < 0.0001) and the BonePlast filler (17.8% ± 1.5%; P < 0.0001). New bone was formed in all groups, particularly adjacent to the interface of graft material with native bone but only to minimal extent. Conclusion: This new approach for craniomaxillofacial augmentation was successfully demonstrated in a rat model. The Norian filler (calcium phosphate) demonstrated superior space preservation abilities. This model may be further applied to test new injectable bone substitutes in the craniomaxillofacial area.

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Bone formation with various bone graft substitutes in critical‐sized rat calvarial defect

Abstract: N-HA was an osteoconductive bone substitute for treating osseous defects in critical size defects of rat calvaria.

Cited by 57 publications

References 32 publications

Maxillary sinus floor augmentation with Bio-Oss or Bio-Oss mixed with autogenous bone as graft in animals: a systematic review

Maxillary sinus floor augmentation with Bio-Oss or Bio-Oss mixed with autogenous bone as graft in animals: a systematic review

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

Minimally Invasive Subpericranial Model: Can It Be Used to Study Bone Substitutes?

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