Bone formation processin porous calcium carbonate and hydroxyapatite

Ohgushi, Hajime; Okumura, M.; Yoshikawa, Takafumi; Inoue, Kohei; Senpuku, N; Tamai, Susumu; Ec, Shors

doi:10.1002/jbm.820260705

Cited by 228 publications

(114 citation statements)

References 20 publications

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“…The bone formation of both calcium carbonate and hydroxyapatite occurred initially on surface of the pore regions and progressed toward the center of the pore and was linked to graft resoption. 20 At present there are two commercially available corals: the Biocoral ® composed of corals on their natural form and Pro Osteon™ composed of coralline material converted to hydroxyapatite.…”

Section: Corals As Graft Materialsmentioning

confidence: 99%

Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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Xenogeneic bone graft materials are an alternative to autologous bone grafting. Among such implants, coralline-derived bone grafts substitutes have a long track record as safe, biocompatible and osteoconductive graft materials. In this review, we present the available literature surrounding their use with special focus on the commercially available graft materials. Corals thanks to their chemical and structural characteristics similar to those of the human cancellous bone have shown great potential but clinical data presented to date is ambiguous with both positive and negative outcomes reported.Correct formulation and design of the graft to ensure adequate osteo-activity and resorption appears intrinsic to a successful outcome.

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Section: Corals As Graft Materialsmentioning

confidence: 99%

Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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“…CO3Ap block thus prepared was resorbed with osteoclasts and replaced with bone, whereas HAp block was not resorbed with osteoclasts and thus would not be replaced with bone [10][11][12][13] . For the structure of cancellous bone, it is clear that the key advantage of cancellous bone lies in a threedimensional fully interconnected porous structure [14][15][16][17][18][19][20] . An interconnected structure promotes rapid cell and tissue penetration and revascularization, and provides a greater surface area than cortical bone 21) .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam

et al. 2011

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Carbonate apatite (CO3Ap) foam may be an ideal bone substitute as it is sidelined to cancellous bone with respect to its chemical composition and structure. However, CO3Ap foam fabricated using -tricalcium phosphate foam showed limited mechanical strength. In the present study, feasibility of the fabrication of calcite which could be a precursor of CO3Ap was studied. Calcite foam was successfully fabricated by the so-called "ceramic foam" method using calcium hydroxide coated polyurethane foam under CO2+O2 atmosphere. Then the calcite foam was immersed in Na2HPO4 aqueous solution for phase transformation based on dissolutionprecipitation reaction. When CaO-free calcite foam was immersed in Na2HPO4 solution, low-crystalline CO3Ap foam with 93-96% porosity and fully interconnected porous structure was fabricated. The compressive strength of the foam was 25.6±6 kPa. In light of these results, we concluded that the properties of the precursor foam were key factors for the fabrication of CO3Ap foams.

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“…Since HA is relatively simple to synthesise using both wet chemical and reactive sintering routes, it has been widely investigated for use as a bone graft replacement [1,2,3]. The osteoconductive nature of the HA also means that it has found significant use as coating on metallic implants, where it can facilitate the attachment of both hard and soft tissues and allow firm attachment of the prosthesis in vivo [4].…”

Section: Introductionmentioning

confidence: 99%

Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces

Smith

Paxton

Hung

et al. 2015

Materials Science and Engineering: C

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Calcium phosphate coatings have been applied to the surface of metallic prostheses to mediate hard and soft tissue attachment for more than 40 years. Most coatings are formed of high purity hydroxyapatite, and coating methods are often designed to produce highly crystalline surfaces. It is likely however, that coatings of lower crystallinity can facilitate more rapid tissue attachment since the surface will exhibit a higher specific surface area and will be considerably more reactive than a comparable highly crystalline surface. Here we test this hypothesis by growing a population of MC3T3 osteoblast-like cells on the surface of two types of hip prosthesis with similar composition, but with differing crystallinity. The surfaces with lower crystallinity facilitated more rapid cell attachment and increased proliferation rate, despite having a less heterogeneous surface topography. This work highlights that the influence of the crystallinity of HA at the nano-scale is dominant over macro-scale topography for cell adhesion and growth.Furthermore, crystallinity could be easily adjusted by without compromising coating purity.These findings could facilitate designing novel coated calcium phosphate surfaces that more rapidly bond tissue following implantation.

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Bone formation processin porous calcium carbonate and hydroxyapatite

Cited by 228 publications

References 20 publications

Is there a role of coral bone substitutes in bone repair?

Is there a role of coral bone substitutes in bone repair?

Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam

Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces

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