Bone formation by vascularized periosteal and osteoperiosteal grafts

Abstract

The osteogenic capacity of vascularized periosteal and osteoperiosteal grafts was investigated in 82 Wistar rats about 8 weeks old. The periosteal flaps, pedicled on the descending genicular artery, were taken by stripping the lower third of the femur. In the right hindleg, the grafts were made with periosteum only, while in the left hindleg, the periosteal flaps were associated with cancellous bone. The animals were divided into two groups of 41. In group I, both the periosteal and osteoperiosteal grafts were placed in contact with cortical bone, and in group II, the grafts were buried in muscle. Subgroups of 8 animals were killed after 1, 2, 4, 8, and 16 weeks postoperatively. The grafted region was evaluated radiographically, macroscopically, and histologically. Membranous ossification was the main source of bone formation. Osteoperiosteal grafts produced a greater amount of new bone than periosteal ones. There was evidence that the contact of the graft with living cortical bone favored bone formation.

Cutaneous Angiosome Territory of the Medial Femoral Condyle Osteocutaneous Flap

“…1 The majority of the cases were upper extremity cases. The series included reconstruction of the radius, 6 ulna, 4 metacarpal, 3 phalanges, 2 and wrist arthrodeses.…”

Autologous mesenchymal stem cells loaded in Gelfoam® for structural bone allograft healing in rabbits

“…Clinical and experimental studies demonstrate periosteum plays an important role in bone healing and remodeling (Camilli and Penteado 1994). Periosteum contains osteoprogenitor cells that are capable of differentiating into osteoblasts and chondrocytes (Nakahara et al 1990).…”

Severe trismus secondary to periosteal osteogenesis after fibula free flap maxillary reconstruction

“…2 The osteogenic potential of vascularized periosteum is well described in the literature, and many factors have been associated with an increased osteogenic activity in periosteal tissue. [3][4][5][6] Clinically significant osteogenesis along the periosteum within the vascular pedicle of a fibula free flap has not been reported. We will present a case in which severe trismus occurred after fibula free flap reconstruction of a maxillary defect secondary to periosteal osteogenesis along the course of the vascular pedicle.…”