Bone: Formation by Autoinduction

Urist, Marshall R.

doi:10.1126/science.150.3698.893

Cited by 5,060 publications

(2,517 citation statements)

References 14 publications

Supporting

Mentioning

2,309

Contrasting

Unclassified

124

Order By: Relevance

“…5 Thus far 15 BMPs have been identi®ed and they are all members of the TGF-b superfamily, with the exception of BMP-1. 6 Their osteoinductive ability in vivo has stimulated potential therapeutic applications in reconstructive orthopaedic, periodontal and craniofacial surgery.…”

Section: Bone Morphogenetic Proteinsmentioning

confidence: 99%

Bone morphogenetic protein-6: potential mediator of osteoblastic metastases in prostate cancer

Thomas

Hamdy

2000

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

The mechanisms by which prostate cancer metastasizes to bone with a strong osteoblastic reaction remain poorly understood. Several factors have been previously implicated, including transforming growth factor-b, ®broblast growth factors, endothelin-1 and bone morphogenetic proteins (BMPs). BMP-6 expression has been shown exclusively in the malignant epithelial cells of prostate cancers that have metastasized, but not in organ con®ned disease. Expression of BMP-6 in radical prostatectomy specimens has been shown to correlate with increased recurrence rates and decreased survival. This article presents the results of work by the authors' group in this ®eld and a current literature review.

show abstract

Section: Bone Morphogenetic Proteinsmentioning

confidence: 99%

Bone morphogenetic protein-6: potential mediator of osteoblastic metastases in prostate cancer

Thomas

Hamdy

2000

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…BMPs are known to induce bone formation (Urist, 1965;Wosney et al, 1988). BMP7 is one of the main sources of BMPs in limb development (Robert, 2007).…”

Section: Introductionmentioning

confidence: 99%

Bone pattern formation in mouse limbs after amputation at the forearm level

Ide

2012

Developmental Dynamics

View full text Add to dashboard Cite

Background: Although urodela amphibians completely regenerate amputated limbs, the potency of limb regeneration in mammalians is very low. In mice and humans, a digit tip regenerates, but no regeneration beyond the digit joint occurs. In this article, we describe the induction of bone formation by BMPs in the forearm, a more proximal region, of neonatal mice. Distal halves of the radius and ulna were removed from limbs amputated at the wrist level in advance, and gelatin rods containing BMPs were grafted in the space of the forearm. BMP-7 and BMP-2 were effective. Results: The induction of bone formation depended on the amount of BMP-7 in grafted gelatin gels. BMP-7 at over 320 ng/limb induced long bones within 10 days. Cartilage formation was always observed before the bone formation as in the case of normal limb development. The origin of cells responsive to BMP-7 is not clear, but the formation of large bone tissues in a relatively short time suggests a wide distribution of precursor cells in the limbs. Grafting of dye-stained mesenchymal tissue fragments suggested that mesenchymal tissues other than the dermis, bone, and joint cartilage are responsive to BMP-7 and form cartilage/bone. Two long bones induced were arranged in parallel fashion in many cases like the radius and ulna. An agonist of hedgehog promoted the formation of bones in the presence of BMP-7. Furthermore, bone elements were fused to stump bones to form a single bone. Conclusions: The results suggest the potency of bone pattern regeneration in the amputated forearm of a neonatal mouse. Developmental Dynamics 241:435-441,

show abstract

“…In 1965, Marshall Urist [6,47] revolutionized the current understanding of fracture healing by hypothesizing the existence of bone morphogenetic proteins (BMPs) in the extracellular collagenous bone matrix. In 1988, Wozney et al [49] identified the genetic sequences of BMPs.…”

Section: Introductionmentioning

confidence: 99%

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Giannoudis

Kanakaris

Dimitriou

et al. 2009

Clin Orthop Relat Res

117

View full text Add to dashboard Cite

Combining autologous bone graft and recombinant human bone morphogenetic protein-7 (BMP-7) to treat long-bone fracture aseptic atrophic nonunions theoretically could promote bone healing at higher rates than each of these grafting agents separately. We retrospectively reviewed prospectively collected data on patient general characteristics, clinical outcomes, and complications over 3 years to determine the healing rates and the incidence of complications and adverse events of this ''graft expansion rationale.'' There were 45 patients (32 male) with a median age of 43 years (range, 19-76 years). Minimum followup was 12 months (mean, 24.5 months; range, 12-65 months). There were seven humeral, 19 femoral, and 19 tibial nonunions. The median number of prior operations was two (range, 1-7). All fractures united. Clinical and radiographic union occurred within a median of 5 months (range, 3-14 months) and 6 months (range, 4-16 months), respectively. Thirty-nine (87%) patients returned to their preinjury occupation at a mean of 4.2 months (range, 3-6 months). The median visual analog scale pain score was 0.9 (range, 0-2.8; maximum 10), and the median functional score was 86 (range, 67-95; maximum 100) at the final followup. BMP-7 as a bone-stimulating agent combined with conventional autograft resulted in a nonunion healing rate of 100% in these 45 patients.

show abstract

Bone: Formation by Autoinduction

Cited by 5,060 publications

References 14 publications

Bone morphogenetic protein-6: potential mediator of osteoblastic metastases in prostate cancer

Bone morphogenetic protein-6: potential mediator of osteoblastic metastases in prostate cancer

Bone pattern formation in mouse limbs after amputation at the forearm level

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Contact Info

Product

Resources

About