Bone–Fat Interaction

Rendina-Ruedy, Elizabeth; Rosen, Clifford J.

doi:10.1016/j.ecl.2016.09.004

Cited by 39 publications

(28 citation statements)

References 76 publications

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“…Over decades of study, accumulating evidence has demonstrated the reciprocality between osteogenesis and adipogenesis, which is well documented in [ 69 , 70 ]. Increased adipogenesis often leads to decreased osteogenesis, vice versa [ 70 ].…”

Section: Differentiation Balance Of Mesenchymal Stem Cells and Hemmentioning

confidence: 99%

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

Zhang

Ran

et al. 2018

Stem Cells International

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Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy. Moreover, the differentiation balance of BMSCs is crucial to hematopoiesis. We highlight the negative effects of differentiation bias of BMSCs on hematopoietic recovery after bone marrow transplantation. Keeping the differentiation balance of BMSCs is critical for hematopoietic recovery. This review summarises current understanding about how BMSC differentiation affects hematopoiesis and its potential application in improving hematopoietic recovery after bone marrow transplantation.

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Section: Differentiation Balance Of Mesenchymal Stem Cells and Hemmentioning

confidence: 99%

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

Zhang

Ran

et al. 2018

Stem Cells International

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“…As we know, bone is a dynamic tissue undergoing continuous resorbing and forming by osteoblasts and osteoclasts. 13 Besides, the relationship between bone and fat formation in the bone marrow is considered inverse. Imbalance between the formation of osteoblasts and adipocytes may cause bone diseases such as osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

UNC‐5 netrin receptor B regulates adipogenesis of human adipose–derived stem cells through JNK pathway

Liu

et al. 2020

J of Oral Rehabilitation

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“…Adipocytes are no longer considered an inert type of cell that just stores fat. It is now clear that adipocytes function as endocrine glands that are capable of synthesizing a number of biologically active compounds that regulate metabolic homeostasis and that have wide‐reaching effects on other organs, such as brain and bone (27, 28); therefore, it is of increasing importance to investigate the regulation of adipogenesis to identify key mediators of adipocyte generation.…”

Section: Discussionmentioning

confidence: 99%

Cysteine‐rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling

Yang

Wang

et al. 2018

FASEB j.

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Emerging evidence suggests that cysteine-rich protein 61 (CYR61) plays a role in the differentiation and development of chondrocytes, osteoblasts, and osteoclasts; however, little is known about its role in adipogenesis. The current study indicates that the expression level of Cyr61 was altered in primary cultured marrow stromal cells and the established mesenchymal cell line, C3H10T1/2, after adipogenic treatment. Overexpressing Cyr61 repressed C3H10T1/2 and primary marrow stromal cells to differentiate into mature adipocytes. Conversely, inhibition of endogenous Cyr61 induced C3H10T1/2 and primary marrow stromal cells to fully differentiate. Mechanism investigations reveal that knockdown of Cyr61 inhibited the nuclear translocation of β-catenin and decreased nuclear protein levels of β-catenin and transcription factor 7-like 2. Moreover, the silencing of Cyr61 increased protein levels of phosphorylated ribosomal protein S6 kinase B1, mammalian target of rapamycin, eukaryotic translation initiation factor 4E-binding protein 1, and ribosomal protein S6-the major components of mammalian target of rapamycin complex 1 (mTORC1) signaling-in C3H10T1/2 cells. Additional investigations demonstrated that treatment with rapamycin significantly attenuated adipocyte formation that was induced by Cyr61 small interfering RNA (siRNA) transfection. Moreover, Cyr61 siRNA also lost its ability to stimulate adipocyte formation under the background of β-catenin overexpression. Taken together, our study provides evidence that CYR61 regulates adipocyte differentiation via multiple signaling pathways that involve at least the inactivation of mTORC1 signaling and the activation of canonical Wnt signaling.-Yang, Y., Qi, Q., Wang, Y., Shi, Y., Yang, W., Cen, Y., Zhu, E., Li, X., Chen, D., Wang, B. Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.

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Bone–Fat Interaction

Cited by 39 publications

References 76 publications

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

UNC‐5 netrin receptor B regulates adipogenesis of human adipose–derived stem cells through JNK pathway

Cysteine‐rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling

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