Bone embrittlement and collagen modifications due to high-dose gamma-irradiation sterilization

Burton, Brianne; Gaspar, Anne; Josey, David; Tupy, J.H.; Grynpas, Marc D.; Willett, Thomas L.

doi:10.1016/j.bone.2014.01.006

Cited by 74 publications

(77 citation statements)

References 51 publications

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“…Studies have determined that changes in collagen content or cross-linking can reduce bone strength [42,43] and while such changes may be the cause of the reduced toughness seen in mdx mouse bone, further investigations will be required to determine if this is the case.…”

Section: Accepted Manuscriptmentioning

confidence: 95%

Prophylactic pamidronate partially protects from glucocorticoid-induced bone loss in the mdx mouse model of Duchenne muscular dystrophy

Yoon

Chen

Grynpas

et al. 2016

Bone

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Section: Accepted Manuscriptmentioning

confidence: 95%

Prophylactic pamidronate partially protects from glucocorticoid-induced bone loss in the mdx mouse model of Duchenne muscular dystrophy

Yoon

Chen

Grynpas

et al. 2016

Bone

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“…This "ductility" also aids fracture toughness (Akkus and Rimnac, 2001a). The collagen is thought to contribute to fracture toughness by various mechanisms including constrained micro-cracking (Akkus and Rimnac, 2001b;Burton et al, 2014) and collagen fibril bridging (Barth et al, 2010(Barth et al, , 2011.…”

Section: Introductionmentioning

confidence: 98%

γ-Irradiation sterilized bone strengthened and toughened by ribose pre-treatment

Willett

Burton

Woodside

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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“…Bone irradiation causes undesirable side effects leading to unfavorable bone remodeling and repair (8)(9)(10)(11) and, in the worst case, osteoradionecrosis (16). In the present study, we exposed cortical bone chips to a gamma radiation dose up to 120 Gy and investigated the subsequent effects on the activity of TGF-β target genes.…”

Section: Discussionmentioning

confidence: 98%

“…Adverse effects include pathologic fractures, continuity defects, and abnormalities in osteosynthesis (8)(9)(10)(11). Substantial evidence indicates that irradiation disrupts bone microvasculature (12,13).…”

Section: Introductionmentioning

confidence: 99%

High-dose irradiation of bone chips preserves the <i>in vitro</i> activity of bone-conditioned medium

et al. 2016

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Extracorporeal irradiation sterilizesresected tumor bone used as autografts in reconstruction surgery. Therapeutic irradiation is a standard technique in head and neck cancer therapy that aims to preserve organ function. Bone irradiation has a complex, mostly inhibitory, effect on remodeling and regeneration, although the underlying mechanisms are still not fully understood. It remains unclear if extracorporeal irradiation affects the paracrine-like activity of the corresponding autografts. We recently reported that bone-conditioned medium from autogenous bone chips contains a number of factors that might affect cell activity. In the present study, we investigated the effects of extracorporeal irradiation of porcine cortical bone chips on the activity of the corresponding bone-conditioned medium. The effects of bone-conditioned medium on the expressions of transforming growth factor-beta (TGF-β) target genes in oral fibroblasts were assessed. Bone-conditioned medium from bone chips exposed to a total radiation dose up to 120 Gy did not affect expressions of TGF-β target genes, including adrenomedullin, BTB/ POZ domain-containing protein 11, proteoglycan 4, NADPH oxidase 4, and interleukin 11, in oral fibroblasts. In conclusion, bone irradiation does not alter the capability of the corresponding bone-conditioned medium to provoke a robust fibroblastic cell response in vitro. (J Oral Sci 58, 325-331, 2016)

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Bone embrittlement and collagen modifications due to high-dose gamma-irradiation sterilization

Cited by 74 publications

References 51 publications

Prophylactic pamidronate partially protects from glucocorticoid-induced bone loss in the mdx mouse model of Duchenne muscular dystrophy

Prophylactic pamidronate partially protects from glucocorticoid-induced bone loss in the mdx mouse model of Duchenne muscular dystrophy

γ-Irradiation sterilized bone strengthened and toughened by ribose pre-treatment

High-dose irradiation of bone chips preserves the <i>in vitro</i> activity of bone-conditioned medium

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