Bone Development in Diabetic Children

Morrison, L. B.; Bogan, Isabel K.

doi:10.1097/00000441-192709000-00003

Cited by 48 publications

(16 citation statements)

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“…Following earlier (4,5,6,7,8,9) suggestions of an increased prevalence of fractures in T1DM, the results of the Iowa Women's Health Study, an 11-year follow-up of 32 089 postmenopausal women, were reported in 2001 (18). Hip fractures were found to be 12 times more common in women with T1DM compared to matched controls.…”

Section: Fracture Riskmentioning

confidence: 95%

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Hough

Pierroz²,

Cooper

et al. 2016

European Journal of Endocrinology

131

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Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased bone resorption. Insulin/IGF1 deficiency appears to be a major pathogenetic mechanism involved, along with glucose toxicity, marrow adiposity, inflammation, adipokine and other metabolic alterations that may all play a role on altering bone turnover. In turn, increasing physical activity in children with diabetes as well as good glycaemic control appears to provide some improvement of bone parameters, although robust clinical studies are still lacking. In this context, the role of osteoporosis drugs remains unknown.

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Section: Fracture Riskmentioning

confidence: 95%

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Hough

Pierroz²,

Cooper

et al. 2016

European Journal of Endocrinology

131

View full text Add to dashboard Cite

show abstract

“…It has been known since the preinsulin era that dia betes mellitus limits the growth velocity of children and adolescents [8], But diabetes can also cause an osteope nia: the princeps description is often attributed to Al bright and Reifenstein [ 1 ], but there are earlier reports of radiological osteopenia in diabetic patients [10], With a combination of macroscopic, radiological and micro scopic interpretation, Hemberg [5] described a 'presenile osteoporosis' in diabetics before the age of 65. Recent diagnostic techniques, such as radiogrammetry and (sin gle and dual) photon absorptiometry, have confirmed and quantitated the osteopenia in the appendicular and axial skeleton of diabetics [2], A decreased bone mass has been found in diabetic children within the first years after diagnosis, but does apparently not worsen as the duration of diabetes increases [3].…”

Section: Diabetes and Osteoporosis In Manmentioning

confidence: 99%

Osteoporosis and Diabetes: Lessons from the Diabetic BB Rat

Verhaeghe¹,

Visser²,

Einhorn³

et al. 1990

Horm Res

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The spontaneously diabetic BB rat was used to study the effect of diabetes on bone. Short-term diabetes (3–4 weeks) resulted in a state of low bone turnover, characterized by a severe decrease in osteoblast/osteoid surface and bone mineral apposition rate on histology, and in serum osteocalcin concentrations. If diabetes was long-term (12 weeks), the parameters of low bone formation were associated with histological evidence of osteoporosis and a decreased bone strength; the relative bone calcium concentration remained normal in diabetes. We conclude that long-standing diabetes results in a low-turnover osteoporosis.

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“…Osteoporosis increases fracture risk. Both male and female T1-diabetic adults and adolescents are vulnerable to decreased bone density and increased fracture risk [7][8][9][10][11][12][13][14][15][16][17][18]. Animal models of T1-diabetes display comparable bone loss to patients thus allowing for extensive investigation of bone pathologies and mechanisms contributing to diabetes-induced bone loss [6,19,20].…”

Section: Introductionmentioning

confidence: 99%

Low Dose Aspirin Therapy Decreases Blood Glucose Levels but Does not Prevent Type I Diabetes-induced Bone Loss

Coe

Denison

McCabe

2011

Cell Physiol Biochem

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Backgroud: Diabetes is strongly associated with increased fracture risk. During T1-diabetes onset, levels of blood glucose and pro-inflammatory cytokines (including TNFα) are increased. At the same time, levels of osteoblast markers are rapidly decreased and stay decreased 40 days later at which point bone loss is clearly evident. Inflammation is known to suppress bone formation and induce bone loss. Previous co-culture studies indicate that diabetic bone is inflamed and diabetic bone marrow is capable of enhancing osteoblast death in vitro. Here we investigate a commonly used non-steroidal anti-inflammatory drug, aspirin, to prevent T1-diabetic bone loss in vivo. Methods: We induced diabetes in 16-week-old male C57BL/6 mice and administered aspirin in the drinking water. Results: Our results demonstrate that aspirin therapy reduced diabetic mouse non-fasting blood glucose levels to less than 400 mg/dl, but did not prevent trabecular and cortical bone loss. In control mice, aspirin treatment increased bone formation markers but did not affect markers of bone resorption or bone density/volume. In diabetic mice, bone formation markers and bone density/volume are decreased and unaltered by aspirin treatment. Bone resorption markers, however, are increased and 2-way ANOVA analysis demonstrates an interaction between aspirin treatment and diabetes (p<0.007). Aspirin treatment did not prevent the previously reported diabetes-induced marrow adiposity. Conclusion: Taken together, our results suggest that low dose aspirin therapy does not negatively impact bone density in control and diabetic mice, but could potentially increase bone resorption in T1-diabetic mice.

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Bone Development in Diabetic Children

Cited by 48 publications

References 0 publications

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Osteoporosis and Diabetes: Lessons from the Diabetic BB Rat

Low Dose Aspirin Therapy Decreases Blood Glucose Levels but Does not Prevent Type I Diabetes-induced Bone Loss

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