Bone density: Is it affected by orchidectomy and radiotherapy given for Stage I seminoma of the testis?

Stutz, Jack; Barry, B.P.; Maslanka, W.; Sokal, M.; Green, D.J.; Pearson, Derek

doi:10.1016/s0936-6555(98)80113-1

Cited by 14 publications

(24 citation statements)

References 8 publications

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“…Thus, although the radiation field may have included an area of the lumbar spine, this has no significant effect on BMD, consistent with the conclusions of Stutz et al (16).…”

Section: Resultssupporting

confidence: 86%

“…It was assumed that localized radiotherapy would not have effects elsewhere on the skeleton and that the dose of radiation to the testes was minimal (<10 cGy). Previous studies in men treated with orchidectomy and radiotherapy for stage I seminoma of the testis that had measured BMD, including irradiated areas of bone, had shown no significant difference between irradiated and nonirradiated sites (16). No patients in our study received total body irradiation.…”

Section: Methodscontrasting

confidence: 58%

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Effect of Chemotherapy on Skeletal Health in Male Survivors from Testicular Cancer and Lymphoma

Brown

Ellis

Silcocks

et al. 2006

Clinical Cancer Research

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Purpose: There are concerns over the late effects of cancer therapy, including accelerated bone loss leading to increased risk of osteoporosis. Treatment-related bone loss is well recognized in breast and prostate cancer, due to overt hypogonadism, but there has been little evaluation of the skeletal effects of chemotherapy alone in adults. This study assesses the extent of bone loss due to previous chemotherapy in men. Experimental Design: The bone mineral density (BMD) of men who had received previously chemotherapy with curative intent for lymphoma or testicular cancers was compared with that of an age-matched population of men from a cancer control population that had not received chemotherapy. BMD was measured by dual-energy X-ray scanning. Additionally, measurement of sex hormones and the bone turnover markers N-telopeptide fragment of type I collagen and bone-specific alkaline phosphatase were done. All statistical tests were two sided. Results: One hundred fifteen chemotherapy-treated patients and 102 cancer controls were recruited. There was no statistical difference in BMD between the chemotherapy and control groups at either spine or hip and the mean BMD values in both groups were no lower than that of a reference population. There were no significant differences in estradiol, luteinizing hormone, and testosterone, but follicle-stimulating hormone values were significantly higher in the chemotherapy group (P = 0.011). The mean values of NH 2 -terminal telopeptide fragment of type I collagen and bone-specific alkaline phosphatase were within the reference ranges. Conclusions: The absence of accelerated bone loss following chemotherapy is reassuring and suggests that standard dose cytotoxic chemotherapy has no lasting clinically important direct effects on bone metabolism.

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“…Thus, although the radiation field may have included an area of the lumbar spine, this has no significant effect on BMD, consistent with the conclusions of Stutz et al (16).…”

Section: Resultssupporting

confidence: 86%

Section: Methodscontrasting

confidence: 58%

Effect of Chemotherapy on Skeletal Health in Male Survivors from Testicular Cancer and Lymphoma

Brown

Ellis

Silcocks

et al. 2006

Clinical Cancer Research

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“…One study demonstrated a significant decrease in bone density in patients who underwent total body RT, although this was believed to be due to induction of hypogonadism rather than direct RT effects on bone (15). A subsequent investigation determined that nodal irradiation for Stage I seminoma has no significant long-term effect on bone density (16). By contrast, another study documented an increase in bone density 3 months after RT for vertebral metastasis (17).…”

Section: Discussionmentioning

confidence: 99%

Bone Density Changes After Radiation for Extremity Sarcomas: Exploring the Etiology of Pathologic Fractures

Dhakal

Chen²,

McCance

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…(26,27) Yet, Stutz ‘evaluation of patients following orchidectomy and radiation treatment for seminoma did not reveal any differences in BMD between irradiated and non-irradiated hips. (28) Nevertheless, there have been clinical studies that have reported the diminution of bone mineral content in the lumbar spine of cervical cancer patients following radiation. (29) Hamada et al described disturbances in bone mineral metabolism of the lumbar vertebra that might be occurring in the early phase of radiation.…”

Section: Discussionmentioning

confidence: 99%

The effect of Amifostine prophylaxis on bone densitometry, biomechanical strength and union in mandibular pathologic fracture repair

Tchanque-Fossuo

Donneys

Sarhaddi

et al. 2013

Bone

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Background Pathologic fractures (Fx) of the mandibles are severely debilitating consequences of radiation (XRT) in the treatment of craniofacial malignancy. We have previously demonstrated Amifostine’s effect (AMF) in the remediation of radiation-induced cellular damage. We posit that AMF prophylaxis will preserve bone strength and drastically reverse radiotherapy-induced non-union in a murine mandibular model of pathologic fracture repair. Materials and Methods Twenty-nine rats were randomized into 3 groups: Fx, XRT/Fx, and AMF/XRT/Fx. A fractionated human equivalent dose of radiation was delivered to the left hemimandibles of XRT/Fx and AMF/XRT/Fx. AMF/XRT/Fx was pre-treated with AMF. All groups underwent left mandibular osteotomy with external fixation and setting of a 2.1mm fracture gap post-operatively. Utilizing micro-computed tomography and biomechanical testing, the healed fracture was evaluated for strength. Results All radiomorphometrics and biomechanical properties were significantly diminished in XRT/Fx compared to both Fx and AMF/XRT/Fx. No difference was demonstrated between Fx and AMF/XRT/Fx in both outcomes. Conclusion Our investigation establishes the significant and substantial capability of AMF prophylaxis to preserve and enhance bone union, quality and strength in the setting of human equivalent radiotherapy. Such novel discoveries establish the true potential to utilize pharmacotherapy to prevent and improve the treatment outcomes of radiation-induced late pathologic fractures.

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Bone density: Is it affected by orchidectomy and radiotherapy given for Stage I seminoma of the testis?

Cited by 14 publications

References 8 publications

Effect of Chemotherapy on Skeletal Health in Male Survivors from Testicular Cancer and Lymphoma

Effect of Chemotherapy on Skeletal Health in Male Survivors from Testicular Cancer and Lymphoma

Bone Density Changes After Radiation for Extremity Sarcomas: Exploring the Etiology of Pathologic Fractures

The effect of Amifostine prophylaxis on bone densitometry, biomechanical strength and union in mandibular pathologic fracture repair

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