Bone density in a population-based cohort of premenopausal adult women with early onset inflammatory bowel disease

Bernstein, Çharles N.; Leslie, William D.; Taback, Shayne

doi:10.1016/s0002-9270(03)00133-3

Cited by 21 publications

(14 citation statements)

References 28 publications

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“…Osteopenia (also called low bone mass) has been reported in patients with chronic inflammatory diseases such as chronic periodontitis [1] and pancreatitis [2], inflammatory bowel disease [3], rheumatorid arthritis [4], and lupus erythematosus [5]. The pathogenesis of low bone mass in patients with such chronic inflammatory diseases is complex.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats

et al. 2010

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Summary-Studies suggest that green tea polyphenols (GTP) or alphacalcidol is promising agent for preventing bone loss. Findings that GTP supplementation plus alphacalcidol administration increased bone mass via a decrease of oxidative stress and inflammation suggest a significant role of GTP plus alphacalcidol in bone health of patients with chronic inflammation.Introduction-Studies have suggested that green tea polyphenols (GTP) or alphacalcidol are promising dietary supplements for preventing bone loss in women. However, the mechanism(s) related to the possible osteo-protective role of GTP plus D 3 in chronic inflammation-induced bone loss is not well understood.

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Section: Introductionmentioning

confidence: 99%

Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats

et al. 2010

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“…[38] Chronic inflammation and increased pro-inflammatory cytokines TNF-α and IL-6 induce bone resorption and bone loss in a number of diseases, such as periodontitis, [39] rheumatoid arthritis, [40] and inflammatory bowel disease. [41] These pro-inflammatory cytokines in obesity stimulates osteoclastactivity and bone resorption through RANKL/RANK/OPG pathways. [7–9] In this study, serum levels of chemerin, as well as TNF-α, were negatively associated with BMD measurements of the lumbar spine in obese population, which is in line with the study by He et al, [42] who also found negative effect of chemerin on BMD in osteoporotic patients.…”

Section: Discussionmentioning

confidence: 99%

Association of chemerin levels and bone mineral density in Chinese obese postmenopausal women

et al. 2016

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Increasing evidence suggests the association between obesity and bone metabolism. However, whether excessive fat accumulation has a beneficial or adverse effect on bone health remains controversial. Chemerin is a novel adipocyte-derived hormone and a chemoattractant cytokine that regulates adipogenesis. This study was performed to investigate the associations of serum chemerin with bone mineral density (BMD) and serum pro-inflammatory cytokine levels in 543 Chinese obese postmenopausal women. BMD of the femoral neck and lumbar spine, lean mass, and fat mass were measured using dual energy X-ray absorptiometry. Anthropometric assessment and laboratory measurements were performed. The age, time after menopause, and fat mass were negatively correlated with femoral and lumbar BMD, whereas lean mass was positively correlated with aforementioned variables. Furthermore, BMD at the lumbar spine was inversely associated with serum chemerin and TNF-α levels (r = −0.155, P = 0.001; r = −0.147, P = 0.001). Multiple linear regression analyses showed that serum chemerin levels were negatively correlated with BMD at the lumbar site after controlling for the age, lean, and fat mass (β = −0.125, P = 0.001). Chronic low-grade inflammation state in obese population has an inverse effect on bone mass. Chemerin as an adipocytokine and chemoattractant negatively affects the bone mass of Chinese obese postmenopausal women. Further studies are needed to confirm the potential role of chemerin in the crosstalk between bone and fat accumulation in obese population.

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“…Chronic inflammation and increased proinflammatory cytokines induce bone resorption and bone loss in patients with periodontitis (Van Dyke and Serhan, 2003), pancreatitis (Mann et al, 2003), inflammatory bowel disease (Bernstein et al, 2003), and rheumatoid arthritis (Romas et al, 2002). It has also been established that upregulated proinflammatory cytokines are primary mediators of osteopenia or osteoporosis.…”

Section: Biologic Mechanisms For the Bone-fat Connectionmentioning

confidence: 99%

Childhood obesity, bone development, and cardiometabolic risk factors

Pollock

2015

Molecular and Cellular Endocrinology

106

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Osteoporosis and obesity are both major public health concerns. It has long been considered that these are distinct disorders rarely found in the same individual; however, emerging evidence supports an important interaction between adipose tissue and the skeleton. Whereas overweight per se may augment bone strength, animal studies suggest that the metabolic impairment that accompanies obesity is detrimental to bone. Obesity during childhood, a critical time for bone development, likely has profound and lasting effects on bone strength and fracture risk. This notion has received little attention in children and results are mixed, with studies reporting that bone strength development is enhanced or impaired by obesity. Whether obesity is a risk factor for osteoporosis or childhood bone health, in general, remains an important clinical question. Here, we will focus on clarifying the controversial relationships between childhood obesity and bone strength development, and provide insights into potential mechanisms that may regulate the effect of excess adiposity on bone.

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Bone density in a population-based cohort of premenopausal adult women with early onset inflammatory bowel disease

Cited by 21 publications

References 28 publications

Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats

Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats

Association of chemerin levels and bone mineral density in Chinese obese postmenopausal women

Childhood obesity, bone development, and cardiometabolic risk factors

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