Bone cross-sectional geometry is not associated with atypical femoral fractures in Asian female chronic bisphosphonate users

Lateral Cortical Thickening and Bone Heterogeneity of the Subtrochanteric Femur Measured With Quantitative CT as Indicators for Early Detection of Atypical Femoral Fractures in Long-Term Bisphosphonate Users

“…The influence of lower limb geometry on fracture might vary depending on ethnicity. A recently published study that also did not observe an association between varus angles of the femoral neck and AFFs in a population of Asian women who were long-term BP users suggested that the neck-shaft angle may not be valuable for identifying patients at higher risk of AFF for every ethnic group [23]. The femoral neck-shaft angle also did not seem to predict the risk of AFF in the Asian population in the current study.…”

“…A number of previous studies found no association between AFFs and generalized cortical thickening [22,23], although the ASBMR defines "localized periosteal or endosteal thickening of the lateral cortex" as one of the major features and "generalized increase in cortical thickness of the femoral diaphysis" as a minor feature of AFFs [6]. In the current study, cortical thickness of the subtrochanteric femur was measured on a cross-sectional image from QCT instead of on a conventional anteroposterior radiograph.…”

Comparative Analysis of T-Score Discordance between a Registry-Based Korean Population and Atypical Femoral Fracture Patients of a Single Institution

“…Weil et al 10) also reported that bone mineral density (BMD) of the LS in AFF cases was significantly lower than that of the femoral neck (FN). Furthermore, in a similar study, Chou et al 11) reported that femur BMD in AFF cases was significantly higher than that in osteoporotic femoral fracture cases.…”

Risedronate complexes with Mg2+, Zn2+, Pb2+, and Cu2+: Species thermodynamics and sequestering ability in NaCl(aq) at different ionic strengths and at T = 298.15 K

“…SIT approach (7) ji is the combination of the specific interaction coefficients of the species involved in the equilibrium and the ions of the supporting electrolyte. For example, in the case of eq.…”

“…Bisphosphonates (BPs) (e.g., alendronate, risedronate, and ibandronate), a class of compounds widely used in medicine as antiresorptive drugs for the treatment of bone disorders such as Paget disease, osteoporosis, hypercalcemia and bone metastasis [1][2][3][4], are known to help maintaining bone mass, to inhibit osteoclast-mediated bone resorption as well as to reduce the risk of both vertebral and nonvertebral fractures [5,6], although some cases of atypical femoral fractures (AFF) have been reported in Asian women with prolonged bisphosphonate exposure [7]. The clinical efficacy of BPs is mainly based on two key properties, i.e.…”