Bone Cancer

Biermann, J. Sybil; Adkins, Douglas R.; Agulnik, Mark; Benjamin, Robert S.; Brigman, Brian E.; Butrynski, James E.; Cheong, David; Chow, Warren; Curry, William T.; Frassica, Deborah A.; Frassica, Frank J.; Hande, Kenneth R.; Hornicek, Francis J.; Jones, Robin L.; Mayerson, Joel L.; McGarry, Sean V.; McGrath, Brian; Morris, Carol D.; O’Donnell, Richard J.; Randall, R. Lor; Santana, Víctor M.; Satcher, Robert L.; Siegel, Henry; Mehren, Margaret von; Bergman, Mary Anne; Sundar, Hema

doi:10.6004/jnccn.2013.0088

Cited by 110 publications

(109 citation statements)

References 206 publications

(301 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The patient should then be staged for extent of disease; guidelines for initial evaluation of a suspected distal femur osteosarcoma include plain radiographs and MRI of the femur, CT scan of the chest, and either technetium-99m-methyl diphosphonate (Tc-99m MDP) whole-body bone scan or PET-CT scan. 15 Additionally, a bone or soft-tissue biopsy is performed to provide a definitive diagnosis; this is usually performed after MRI so that the imaging can help guide the biopsy location. It can be prior to remaining staging studies to avoid unnecessary radiation exposure in case a benign diagnosis is made.…”

Section: Team Approachmentioning

confidence: 99%

Team Approach: Osteosarcoma of the Distal Part of the Femur in Adolescents

et al. 2017

View full text Add to dashboard Cite

Osteosarcoma, while rare, is the most common primary bone cancer and accounts for up to 10% of all new pediatric cancer diagnoses annually in the United States. Most commonly, osteosarcoma affects the distal femur and occurs as a high-grade intramedullary (conventional) subtype. Patients with osteosarcoma are treated with a multi-disciplinary team approach.1 Often, an orthopaedic oncologist initiates the workup after making a presumptive diagnosis based on classic clinical and radiographic findings. Advanced imaging and a tissue biopsy are obtained to evaluate the extent of disease and to histologically confirm the diagnosis. Musculoskeletal radiologists and pathologists are key team members who evaluate the imaging and tissue samples to make a definitive diagnosis, establish a prognosis, and help the clinicians develop a treatment plan. Medical/pediatric oncologists are essential team members who provide the appropriate neoadjuvant and adjuvant chemotherapy treatment and assist with long-term surveillance to monitor for local or distant relapse. Orthopaedic oncologists develop and execute a plan for resection of the tumor followed by appropriate reconstruction. The current standard of care for distal femoral osteosarcoma is neoadjuvant chemotherapy followed by limb salvage for the surgically resectable tumor, reconstruction of the bone and soft tissue defect, and adjuvant chemotherapy. The survival for patients with isolated osteosarcoma is approximately 70% and has not substantially improved in over 25 years.2–6

show abstract

Section: Team Approachmentioning

confidence: 99%

Team Approach: Osteosarcoma of the Distal Part of the Femur in Adolescents

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Osteosarcoma(OS) is the most common primary malignant bone tumor, which mainly affects children and adolescents [1]. The prognosis of patients with osteosarcoma can be improved with the combination of surgery and chemotherapy, and the 5-year survival rate has reached 60% to 70% in recent years [2].…”

Section: Ntro Uctionmentioning

confidence: 99%

Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma

Liu

Zhang

Zou

et al. 2017

Cell Physiol Biochem

112

View full text Add to dashboard Cite

Background/Aims: Osteosarcoma (OS) is the most common primary malignant bone tumor tumorigenesis and progression are still poorly understood. Circular RNAs (circRNAs) have been This study aims to investigate the global changes in the expression pattern of circRNAs in osteosarcoma and provide a comprehensive understanding of differentially expressed circRNAs. Methods: Microarray based circRNA expression was determined in osteosarcoma cell lines and mRNA interaction network was predicted using bioinformatics. Gene Ontology analysis and 4 predict the functions of differentially expressed circRNAs. Results: We revealed a number of role of circRNAs in OS. Among these differentially expressed circRNAs, hsa_circRNA_103801 was up-regulated in both osteosarcoma cell lines and tissues, while hsa_circRNA_104980 was down-regulated. The most likely potential target miRNAs for hsa_circRNA_103801 include hsamiR-370-3p, hsa-miR-338-3p and hsa-miR-877-3p, while the most potential target miRNAs of hsa_circRNA_104980 consist of hsa-miR-1298-3p and hsa-miR-660-3p. Functional analysis and angiogenesis pathway, the Rap1 signaling pathway and the PI3K-Akt signaling pathway, while hsa_circRNA_104980 was related to some pathways such as the tight junction pathway.

show abstract

“…Following treatment, history and physical examinations and imaging studies were performed according to the National Comprehensive Cancer Network guidelines. [6] The date of last follow-up was December 11, 2013. This study was approved by the institutional review board.…”

Section: Methods Patient Population Treatment and Follow-upmentioning

confidence: 99%

“…[4,5] Wide surgical excision has been the cornerstone of management of chordomas of the mobile spine and sacrum. [6] While surgery can improve overall survival and has been associated with improved disease-free and local recurrence-free survival, it can result in significant morbidity and functional consequences, particularly when high sacrectomy is required. [4,[7][8][9] Moreover, local recurrence rates in some surgical series are as high as 50-100% with subtotal resection compared to 0-53% with en bloc resection with clear margins.…”

Section: Introductionmentioning

confidence: 99%

18F-FMISO PET/CT Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine

Cheney¹,

Chen

Lim

et al. 2014

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

SummaryLocal recurrence (LR) rates in chordoma patients following surgery ± radiation therapy (RT) or definitive RT are high. Tumor hypoxia is associated with radioresistance and LR. In this prospective study, [ 18 F]-FMISO-PET/CT detected hypoxic tumor sub-volumes in 60% of patients with chordoma of the mobile and sacrococcygeal spine, the majority of which were sufficiently large to allow an RT boost. Further study of hypoxia-directed, dose-escalated RT, particularly in patients at high risk for LR, is warranted.Purpose/Objectives-Local recurrence (LR) rates in chordoma patients following surgery ± radiation therapy (RT) or definitive RT are high. Tumor hypoxia is associated with radioresistance and LR. [ 18 F] fluoromisonidazole positron emission tomography/computed tomography (FMISO-PET/CT) can visualize skull base chordoma hypoxic sub-volumes (HSV) and feasibility of hypoxia-directed RT dose-escalation has been demonstrated in head and neck cancer. This study investigates FMISO-PET/CT detection of targetable HSVs in chordoma of the mobile or sacrococcygeal spine.Methods and Materials-A prospective, pilot study of 20 patients with primary or locally recurrent chordoma of the mobile or sacrococcygeal spine treated with proton or combined proton/ photon RT ± surgery was completed. FMISO-PET/CT was performed prior to RT and after 19.8-34.2 GyRBE (relative biologic effectiveness). Gross tumor volumes (GTV) were delineated Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and HSVs defined including voxels with standardized uptake values ≥ 1.4 times the muscle mean. Clinical characteristics and treatments received were compared between patients with and without HSVs. Conclusions-FMISO-PET/CT detection of targetable HSVs within patients undergoing RT ± surgery for treatment of chordoma of the mobile and sacrococcygeal spine is feasible. The study's inability to attribute interval HSV changes to treatment, rapidly changing hypoxic physiology, or imaging inconsistencies is a limitation. Further study of double-baseline FMISO-PET/CT and hypoxia-directed RT dose-escalation, particularly in patients at high risk for LR, is warranted. NIH Public Access Results-FMISO-PET/CT

show abstract

Bone Cancer

Cited by 110 publications

References 206 publications

Team Approach: Osteosarcoma of the Distal Part of the Femur in Adolescents

Team Approach: Osteosarcoma of the Distal Part of the Femur in Adolescents

Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma

18F-FMISO PET/CT Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine

Contact Info

Product

Resources

About