2004
DOI: 10.1016/j.bone.2004.02.018
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Bone biomechanical properties in LRP5 mutant mice

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Cited by 143 publications
(101 citation statements)
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“…The G171V mutation was found to have greater structural and material strength and tibial stiffness (26) and increased vertebral compressive and femoral bending strengths. (26) In humans clinically presenting with increased bone mass and later shown to be carriers of the T253I-Lrp5 genotype, the strength of trabecular bone was increased, (13) suggesting that biomechanical properties are changed in Lrp5-HBM patients. These biochemical properties may account for the lower prevalence of fractures observed compared to those with autosomal dominant osteopetrosis type II.…”
Section: Discussionmentioning
confidence: 95%
“…The G171V mutation was found to have greater structural and material strength and tibial stiffness (26) and increased vertebral compressive and femoral bending strengths. (26) In humans clinically presenting with increased bone mass and later shown to be carriers of the T253I-Lrp5 genotype, the strength of trabecular bone was increased, (13) suggesting that biomechanical properties are changed in Lrp5-HBM patients. These biochemical properties may account for the lower prevalence of fractures observed compared to those with autosomal dominant osteopetrosis type II.…”
Section: Discussionmentioning
confidence: 95%
“…Some affected family members also have torus platinus phenotype [58]. A corresponding gain-of-function mouse model was generated, which bears the G171V mutation ascribed to human high bone mass phenotype [60,61]. The Lrp5 G171 mice have increased bone mineral density(BMD) as a result of constitutively active receptor function.…”
Section: Lrp5mentioning
confidence: 99%
“…The converse is found in patients with dominant "gain-of-function" mutations in LRP5 which exhibit abnormally high bone density [7,8]. A transgenic mouse model carrying a human LRP5 high bone mass mutation exhibited significant increases in bone density and mechanical properties [9,10]. Studies have shown that removing one Lrp6 copy from Lrp5 −/− mice increases the osteoporosis severity, suggesting that both LRP5 and LRP6 are critical determinants of bone mass [11].…”
Section: Introductionmentioning
confidence: 99%