Bone Biology and the Clinical Implications for Osteoporosis

Downey, Patricia; Siegel, Michael I.

doi:10.1093/ptj/86.1.77

Cited by 197 publications

(149 citation statements)

References 30 publications

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“…No presente estudo a região da crista óssea foi mais atingida devido ao maior teor de tecido ósseo esponjoso, o qual, geralmente, apresenta taxa metabólica maior, respondendo mais rapidamente às mudanças mecânicas do que o osso cortical (Downey & Siegel, 2006). Na análise histomorfométrica notou-se diminuição significativa do POA da mandíbula e do POT do fêmur nos animais tratados com glicocorticóide, evidenciando a redução óssea alveolar mandibular e femural encontrada por outros autores (Fujita et al, 2008;Mahl & Fontanella, 2008;Pinto et al, 2006;Natsui et al, 2006).…”

Section: Resultsunclassified

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Lucinda¹,

Vieira²,

Salvador³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Este trabalho investigou os efeitos do tratamento por vinte dias com extrato de Ginkgo biloba (EGb) na osteoporose induzida por glicocorticóides. Foram utilizadas 36 ratas divididas em seis grupos (n=6): Controle, osteoporose, controle positivo, EGb1 (14 mg EGb/mg/kg/dia), EGb2 (28 mg EGb/kg/dia) e EGb3 (56 mg EGb/kg/dia). Os tratamentos foram realizados por vinte dias, após a indução da osteoporose. Após a eutanásia foram removidos o fêmur e a mandíbula de todos os animais. A mandíbula esquerda foi radiografada digitalmente para avaliação da cortical e do suporte ósseo periodontal (SOP). A análise histomorfométrica foi realizada no fêmur e mandíbula direitos. O grupo controle foi comparado ao grupo osteoporose (Teste t de Student) e os demais grupos foram submetidos a ANOVA, seguido do teste post-hoc de Dunnett. Houve redução significava do SOP mesial, percentual ósseo alveolar (POA) mandibular, percentual ósseo trabecular (POT) do fêmur no grupo osteoporose. Houve aumento do SOP mesial no grupo controle positivo, EGb2 e EGb3. O POA da mandíbula e o POT do fêmur aumentaram nos grupos EGb2 e EGb3. O EGb nas doses de 28 mg/kg e 56 mg/kg recuperou de forma significativa o SOP mesial, o POA da mandíbula e o POT do fêmur. Unitermos:Ginkgo biloba, osteoporose, radiografia, histomorfometria, alendronato de sódio, ratos.ABSTRACT: "Effect of the aqueous extract of Ginkgo biloba L., Ginkgoaceae, in induced osteoporosis in Wistar rats." The objective of this study was to investigate the effect of a 20 day treatment with extract of Ginkgo biloba (EGb) in glucocorticoid-induced-osteoporosis. 36 rats were divided into six groups (n=6): control, osteoporosis, positive control, EGb1 (14 mg EGb/kg/day), EGb2 (28 mg EGb/kg/day) and EGb3 (56 mg EGb/kg/day). Treatments were conducted for twenty days, after osteoporosis was induced. Following euthanasia the femur and mandible of all animals were removed. The left mandible was radiographed to evaluate the cortical and the periodontal bone support (PBS). The histomorphometric analysis was performed on the right mandible and the right femur. The control group was compared with the osteoporosis group (Student's t-test). The other groups were analyzed through ANOVA test followed by Dunnett post-hoc test. There was a significantly reduction in the mesial PBS, in the percentage of the alveolar bone (PAB) of the mandible and percentage of the trabecular bone (PTB) of the femur in the osteoporosis group. There was an increase in the mesial PBS in the positive control group, EGb2 and EGb3. The PAB of the mandible and the PTB of the femur increased in the EGb2 and EGb3 groups. The EGb in the 28 mg/kg and 56 mg/kg doses were effective to increase the mesial PBS, the PAB of the mandible and the PTB of the femur.Keywords: Ginkgo biloba, osteoporosis, radiography, histomorphometric, sodium alendronate, rats. INTRODUÇÃOA osteoporose é caracterizada por uma redução na quantidade de tecido ósseo por unidade de volume (Hallworth, 1998) e por uma deteriorização da microarquitetura deste tecido...

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Section: Resultsunclassified

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Lucinda¹,

Vieira²,

Salvador³

et al. 2010

Rev. bras. farmacogn.

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“…Dual X-ray absorptiometric (DXA) measurements of areal BMD (g/cm 2 ) at the lumbar spine L1-L4) and the femoral neck were carried out using a Lunar DPX Prodigy densitometer (Lunar, Madison, WI, USA). Daily standardized measurement of a Lunar phantom and Hologic Anatomic spine phantom served as a quality control for the bone densitometer.…”

Section: Bmd Measurementsmentioning

confidence: 99%

“…The bone remodeling unit is composed of osteoblasts, which form bone, and osteoclasts, which break down bone [2]. The osteoblast and osteoclast differentiation and activation depend on a family of biologically related TNF/TNF-like proteins: osteoprotegerin (OPG), receptor activator of nuclear factor (NF) κB (RANK), and RANK ligand (RANKL).…”

Section: Introductionmentioning

confidence: 99%

Insulin-Like Growth Factor-1 and Osteocalcin Are Correlated with Markers of Osteoporosis in Postmenopausal Women with Type-2 Diabetes

Kamel

Helmy²,

Rayah³

et al. 2013

OJEMD

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Objective: The study was conducted to evaluate the relation between insulin-like growth factor-1 and osteocalcin and markers of bone modulation (osteoprotegerin; OPG, receptor activator nuclear kappa B; RANK and RANK ligand; RANKL) in postmenopausal Type 2 diabetic women with and without osteoporosis. Methods: The study was conducted on 90 female divided into three groups (30 each). Group I included healthy postmenopausal women as a control, Group II included diabetic postmenopausal women without osteoporosis Group III included diabetic postmenopausal women with osteoporosis. Fasting blood samples were obtained for the determination of blood glucose, HbA1c, total and ionized calcium, OPG, RANK and RANKL. Also the levels of IGF-1 and osteocalcin were assessed. Results: In postmenopausal Type 2 diabetic women, the osteoporosis resulted in derangement in OPG/sRANKL system. The serum level of OPG was elevated while sRANKL declines in osteoporotic postmenopausal Type 2 diabetic women. IGF-1 level decreased in diabetic postmenopausal women but those women with osteoporosis showed a great decline by about 60%. IGF-1 level in osteoporotic diabetic postmenopausal women was correlated with BMD and most bone turnover markers (OPG, sRANKL, OPG/sRANKL). Osteocalcin declined significantly only in those women with osteoporosis not without osteoporosis. Conclusions: The circulating levels of OPG and sRANKL were not useful markers for bone status in postmenopausal women while the circulating levels of IGF-1 and osteocalcin might give useful information about bone status in postmenopausal diabetic women.

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“…Bone lining cells are rooted from mesenchymal stem cells or osteoprogenitor cells, which is an inactive form of osteoblasts known as "resting osteoblasts". A study reported that bone lining cells might be an osteoblast precursor that regulates crystal growth of bone mineral or a barrier between extracellular fluid and bone (Downey 2006, Datta 2008, Lorenzo 2008, Bonewald 2011.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Long Term Administration of Glucocorticoid to Bone Lining Cells Apoptosis

Sari¹

2017

FMI

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Bone Biology and the Clinical Implications for Osteoporosis

Cited by 197 publications

References 30 publications

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Insulin-Like Growth Factor-1 and Osteocalcin Are Correlated with Markers of Osteoporosis in Postmenopausal Women with Type-2 Diabetes

The Effect of Long Term Administration of Glucocorticoid to Bone Lining Cells Apoptosis

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