Bone and soft tissue tumors at the borderlands of malignancy

Crim, Julia R.; Layfield, Lester J.

doi:10.1007/s00256-022-04099-1

Cited by 5 publications

(3 citation statements)

References 69 publications

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“…We also found that intermediate tumors were difficult to distinguish from malignant ones by ultrasound. Intermediate tumors are characterized by locally aggressive growth, which may present as destruction of surrounding tissues in ultrasound images 29 , and this has an impact on the diagnostic specificity. Besides, we found variability in diagnostic sensitivity among radiologists, which improved with accumulated work experience.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound performance in pediatric deep soft-tissue tumor characterization

Li,

Chen,

Jin

et al. 2023

Sci Rep

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This study investigated the performance of ultrasonography in diagnosing deep soft-tissue tumors and tumor-like lesions in children with histological results. Demographic information and ultrasound characteristics of benign and malignant masses were statistically analyzed. Three radiologists (Radiologists 1, 2, and 3) independently reviewed the ultrasonography studies while being blinded to the medical history and other imaging findings. The 82 lesions included in the study were histopathologically classified as malignant (n = 25) or benign (n = 57). No statistically significant differences were observed between the benign and malignant subgroups regarding age (p = 0.059), sex (p = 1.0), disease course (p = 0.812), presence or absence of symptoms (p = 0.534), maximum diameter (p = 0.359), margin (p = 1.0), calcification (p = 0.057), or blood Adler type (p = 0.563). However, statistically significant differences were observed between the benign and malignant subgroups in terms of isolated or Multiple occurrences (p < 0.001), history of malignancy (p < 0.001), shape (p < 0.001), and echogenicity (p < 0.001). Parameters such as tumor shape (p = 0.042, OR = 6.222), single or multiple occurrences (p = 0.008, OR = 17.000), and history of malignancy (p = 0.038, OR = 13.962) were identified as independent predictors of benign and malignant tumors. The diagnostic sensitivities evaluated by the three radiologists were 68.0%, 72.0%, 96.0%, respectively, while the specificities were 77.2%, 82.5%, 77.2%, respectively. Ultrasound demonstrates good performance in the diagnosis of benign deep lesions such as hemangiomas/venous malformation and adipocytic tumors. Multiple irregular morphologies and a history of malignancy were identified as independent risk factors for malignant masses. The experience of radiologists in recognizing specific tumors is important. Careful attention should be paid to masses with ambiguous ultrasound features, as well as small lesions.

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Section: Discussionmentioning

confidence: 99%

Ultrasound performance in pediatric deep soft-tissue tumor characterization

Li,

Chen,

Jin

et al. 2023

Sci Rep

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“… 1 Moreover, some types of musculoskeletal tumors can have equivocal imaging features make it difficult to determine if they will show aggressive behavior and atypical lipomatous tumor or grade 1 liposarcoma is one of them. 1 , 2 , 27 If diagnostic imaging is not fully conclusive for a benign lipoma, differentiation of lipoma variants from liposarcoma is required. 2 Many biopsy techniques have been proposed, including fine-needle aspiration, core needle biopsy, and incisional biopsy.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic En-Bloc Resection of Lipoma of the Tibialis Anterior Tendon

Woo,

Lui

2023

Arthroscopy Techniques

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“…Risk factors include family history, obesity, and inactivity [ 10 ]. Lesions usually present as asymptomatic, painless soft tissue masses and may enlarge slowly [ 9 , 11 ]. Clinical symptoms are uncommon but include local pain, tenderness, and nerve compression [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Desmoid Fibromatosis Fused With a Lipoma in the Upper Arm

Traub,

De Jager,

Hofmann

et al. 2024

Cureus

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Lipoma, the most common mesenchymal tumor, often appears as a slow-growing mass in the musculoskeletal system (MSK). While generally non-invasive, their location can cause symptoms. Desmoid fibromatosis (DF), a rare and locally aggressive neoplasm, poses challenges in MSK system diagnosis and management due to its infiltrative nature. Despite lacking metastatic potential, DF has a high recurrence rate, classifying it as "intermediate, locally aggressive" in the WHO classification. Collaborative efforts among orthopedic surgeons, radiologists, and pathologists are crucial for accurate diagnosis and treatment planning for all tumors of the MSK system. This case report presents the first documented example of a DF within a lipoma, highlighting the challenges of diagnosing and treating musculoskeletal tumors.

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Bone and soft tissue tumors at the borderlands of malignancy

Cited by 5 publications

References 69 publications

Ultrasound performance in pediatric deep soft-tissue tumor characterization

Ultrasound performance in pediatric deep soft-tissue tumor characterization

Endoscopic En-Bloc Resection of Lipoma of the Tibialis Anterior Tendon

Desmoid Fibromatosis Fused With a Lipoma in the Upper Arm

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