Bone and Skeletal Muscle: Neighbors With Close Ties

DiGirolamo, Douglas J.; Kiel, Douglas P.; Esser, Karyn A.

doi:10.1002/jbmr.1969

Cited by 161 publications

(132 citation statements)

References 131 publications

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“…The factors bone mass and muscle strength correlated negatively with age, and the decline of those two factors was strongly associated with a decrease in muscle CSA. Since bone and skeletal muscle are coupled in mass and share a functional relationship [10], it is predictable that muscle CSA is proportional to BMD-related parameters derived from QCT analyses for the factor bone mass. Muscle CSA is also correlated with grip strength for the factor muscle strength, and a loss of muscle mass and a subsequent decline in muscle function and strength is concomitant with aging [11].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, muscle weakness is associated with an increased risk of falls and bone fractures, and a decrease in BMD [12,13]. Many factors may contribute to a decline in both BMD and skeletal muscle mass as people age, including lower levels of sex steroids, their genetic background, and reduced mechanical forces [10]. For women especially, it is well known that diminished estrogen levels are not only a major contributing factor to bone loss and increased skeletal fragility, but also trigger muscle loss, muscle weakening, and declines in optimal physical performance [14].…”

Section: Discussionmentioning

confidence: 99%

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Factors that characterize bone health with aging in healthy postmenopausal women

et al. 2014

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The exponential increase in the incidence of fragility fractures in older people is attributed to attenuation of both bone strength and neuromuscular function. Decrease in bone mineral density (BMD) does not entirely explain this increase. The objective of this study is to investigate the effect of age on various parameters related to bone health with aging, and to identify combinations of factors that collectively express the bone metabolic state in healthy postmenopausal women. Height, weight, and grip strength were measured in 135 healthy postmenopausal volunteer women. Hip BMD, biomechanical indices derived from quantitative computed tomography (QCT), cross-sectional areas of muscle and fat of the proximal thigh, and various biochemical markers of bone metabolism were measured. A smaller group of factors explanatory for bone health was identified using factor analysis and each was newly named. As a result, the factors bone mass, bone turnover, bone structure, and muscle strength had the greatest explanatory power for assessing the bone health of healthy postmenopausal women. Whereas dual X-ray absorptiometry parameters only loaded on the factor bone mass, QCT parameters loaded on both the factors bone mass and bone structure. Most bone turnover markers loaded on the factor bone turnover, but deoxypyridinoline loaded on both bone turnover and muscle strength. Age was negatively correlated with bone mass (r = -0.49, p < 0.001) and muscle strength (r = -0.67, p < 0.001). We conclude that aging is associated as much with muscle weakening as with low BMD. More attention should be paid to the effects of muscle weakening during aging in assessments of bone health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Factors that characterize bone health with aging in healthy postmenopausal women

et al. 2014

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“…Reduced physical activity, a common feature of COPD [176] is a common pathogenic mechanism for muscle wasting and osteoporosis [177]. Moreover, there is evidence supporting an endocrine loop connecting muscle and bone [178,179].…”

Section: Doi: 101183/0903193600134014mentioning

confidence: 99%

Ageing and the border between health and disease

2014

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Ageing is associated with a progressive degeneration of the tissues, which has a negative impact on the structure and function of vital organs and is among the most important known risk factors for most chronic diseases. Since the proportion of the world's population aged .60 years will double in the next four decades, this will be accompanied by an increased incidence of chronic age-related diseases that will place a huge burden on healthcare resources.There is increasing evidence that many chronic inflammatory diseases represent an acceleration of the ageing process. Chronic pulmonary diseases represents an important component of the increasingly prevalent multiple chronic debilitating diseases, which are a major cause of morbidity and mortality, particularly in the elderly. The lungs age and it has been suggested that chronic obstructive pulmonary disease (COPD) is a condition of accelerated lung ageing and that ageing may provide a mechanistic link between COPD and many of its extrapulmonary effects and comorbidities. In this article we will describe the physiological changes and mechanisms of ageing, with particular focus on the pulmonary effects of ageing and how these may be relevant to the development of COPD and its major extrapulmonary manifestations. @ERSpublications Premature ageing of the lung may constitute pathogenetic mechanisms contributing to COPD

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“…A decrease in lean or muscular mass reduces strength and muscle tone, resulting in an increase in the risk of falls which, because of the loss of bone tissue (osteopenia) in sarcopenic patients [40], can lead to fractures that produce disability and dependence (Figure 3). …”

Section: Screening For Sarcopenic Obesitymentioning

confidence: 99%

Challenges in Treatment of Obesity in the Elderly

Sajoux¹,

Bellon²,

Vidal³

2017

EMIJ

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Obesity is a very common problem that affects one in three people over 65 in Spain. In addition to the risk derived from the appearance of comorbidities in organs and systems, obesity in seniors exhibits a particular set of characteristics, such as loss of muscle mass and a specific distribution of fat which directly contributes to an increase in morbimortality. The purpose of this review is to study the epidemiology and physiopathological mechanisms of obesity in the elderly, as well as the therapeutic approach aimed at preserving lean mass in these patients. An extensive bibliographical search was carried out using scientific publications in various specialised electronic databases (PubMed, Scielo and Elsevier) and Google Scholar. For obese patients over 65 years of age, preserving muscle mass is a priority in any weight-loss programme, as this is associated with decreased cardiometabolic risk and increased resistance which in turn inversely correlates with mortality. For this reason, reducing calorie intake while maintaining a high protein intake is recommended. This goal can be attained through a very-low-calorie diet accompanied by a personalised physical exercise programme to improve the patient's functional capacity.

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Bone and Skeletal Muscle: Neighbors With Close Ties

Cited by 161 publications

References 131 publications

Factors that characterize bone health with aging in healthy postmenopausal women

Factors that characterize bone health with aging in healthy postmenopausal women

Ageing and the border between health and disease

Challenges in Treatment of Obesity in the Elderly

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