Bone Allografts In Dentistry: A Review

Ti, Malinin; Ak, Garg; Ht, Temple

doi:10.4172/2161-1122.1000199

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…They are highly biocompatible materials but only disadvantage of the material is long resorption period. [7][8][9][10]…”

Section: Plastic Materialsmentioning

confidence: 99%

Various materials used for the repair of bone defects: A review

Fatima¹,

Negi²,

Jarial³

et al. 2023

JDP

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Now a days most commonly used material to treat the defects in the bone after trauma or after any pathology are bone grafts. Bone grafting is a procedure which is performed surgically to join any defect which is surrounding the bone or for the union of the bone. It was found that the graft material which are allogenic in nature as well as other bioactive synthetic substitutes of the bone graft material shows good integration with the remaining bone. To increase the chances of acceptance of these allogenic bone graft materials and others synthetic bioactive graft materials addition of different growth factors for e.g. such as bone morphogenic proteins, platelet rich plasma, platelet rich fibrin have been considered very well. Bone is found to be the second commonly transplanted tissue after the blood. There are various methods present in the treatment of the bone defects such as guided regeneration of bone, use of stem cells and bone grafts, but bone graft shows promising results in the terms of maintaining the normal outline structure of the bone, bone grafts helps in maintaining the aesthetic restoration, helps in eliminating the space or defect which is surrounding the bone due to trauma or due to any pathological condition, helps in providing the width or height for the ease of placement of implant in the oral cavity.

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“…They are highly biocompatible materials but only disadvantage of the material is long resorption period. [7][8][9][10]…”

Section: Plastic Materialsmentioning

confidence: 99%

Various materials used for the repair of bone defects: A review

Fatima¹,

Negi²,

Jarial³

et al. 2023

JDP

View full text Add to dashboard Cite

show abstract

“…Allogeneic bone grafts are reliable and have been used extensively for decades as an alternative to ABGs 8 , 9 . The amount of allogeneic bone is virtually unlimited, and it can be obtained in various sizes and shapes (e.g., blocks, blades, paste, putty, powder, chips, injectable forms).…”

Section: Introductionmentioning

confidence: 99%

A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models

Tournier

Guicheux

Paré

et al. 2021

Sci Rep

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In skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allogenic bone graft in the form of a paste has been developed. In this study, the regenerative potential of this paste was assessed and compared to its clinically used precursor form allogenic bone particles. Compared to the particular bone graft, the bone paste allowed better attachment of human mesenchymal stromal cells and their commitment towards the osteoblastic lineage, and it induced a pro-regenerative phenotype of human monocytes/macrophages. The bone paste also supported bone healing in vivo in a guide bone regeneration model and, more interestingly, exhibited a substantial bone-forming ability when implanted in a critical-size defect model in rat calvaria. Thus, these findings indicate that this novel partially demineralized allogeneic bone paste that combines substantial bone healing properties and rapid and ease-of-use may be a promising alternative to allogeneic bone grafts for bone regeneration in several clinical contexts of oral and maxillofacial bone grafting.

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“…Allogeneic bone is a reliable alternative to autologous bone and it is increasingly being used in numerous indications such as oral surgery (e.g., sinus floor elevation, horizontal/vertical augmentation, alveolar socket preservation) (Kinaci et al, 2014;Malinin et al, 2014;Elakkiya et al, 2017), foot/hand surgeries, arthroplasties or vertebral fusion (Liao et al, 2016;Tuchman et al, 2017). In these clinical indications, allogeneic bone grafts (BGs) exhibit the same bone healing capacities as autologous BG (Del Fabbro and Testori, 2004;Motamedian et al, 2016;Hernigou et al, 2017;Sakkas et al, 2017;Ozgul et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

An Extrudable Partially Demineralized Allogeneic Bone Paste Exhibits a Similar Bone Healing Capacity as the “Gold Standard” Bone Graft

Tournier

Guicheux

Paré

et al. 2021

Front. Bioeng. Biotechnol.

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Autologous bone grafts (BGs) remain the reference grafting technique in various clinical contexts of bone grafting procedures despite their numerous peri- and post-operative limitations. The use of allogeneic bone is a viable option for overcoming these limitations, as it is reliable and it has been widely utilized in various forms for decades. However, the lack of versatility of conventional allogeneic BGs (e.g., blocks, powders) limits their potential for use with irregular or hard-to-reach bone defects. In this context, a ready- and easy-to-use partially demineralized allogeneic BG in a paste form has been developed, with the aim of facilitating such bone grafting procedures. The regenerative properties of this bone paste (BP) was assessed and compared to that of a syngeneic BG in a pre-clinical model of intramembranous bone healing in critical size defects in rat calvaria. The microcomputed tridimensional quantifications and the histological observations at 7 weeks after the implantation revealed that the in vivo bone regeneration of critical-size defects (CSDs) filled with the BP was similar to syngeneic bone grafts (BGs). Thus, this ready-to-use, injectable, and moldable partially demineralized allogeneic BP, displaying equivalent bone healing capacity than the “gold standard,” may be of particular clinical relevance in the context of oral and maxillofacial bone reconstructions.

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Bone Allografts In Dentistry: A Review

Cited by 7 publications

References 43 publications

Various materials used for the repair of bone defects: A review

Various materials used for the repair of bone defects: A review

A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models

An Extrudable Partially Demineralized Allogeneic Bone Paste Exhibits a Similar Bone Healing Capacity as the “Gold Standard” Bone Graft

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