Bone age as a correction factor for the analysis of trabecular bone score (TBS) in children

Guagnelli, Miguel Angel; Winzenrieth, Renaud; López-González, Desirée; McClung, Michael R.; Río, Luis Del; Clark, Patricia

doi:10.1007/s11657-019-0573-6

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…Increasing age was a predictor of increased risk of fracture, which has been confirmed in previous studies. [35][36][37] The duration of illness in postmenopausal women was one of the predictors of a higher risk of fracture.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

et al. 2021

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Background: Rheumatoid arthritis (RA) presents with inflammation in the joints and bony tissues around them. The trabecular bone score (TBS) is a relatively new indicator that predicts fracture risk better than bone mineral density (BMD). The aim of the current study was to measure TBSs and BMD of patients with RA referring to Resalat Hospital, Tehran. Methods: In this descriptive cross-sectional study, 129 men and women with RA entered the study through convenient sampling during 2016. TBS and BMD were measured in L1-L4. The relationships between age, sex, body mass index (BMI), duration of disease, and daily corticosteroids dose with TBS and BMD were determined by chi-square test, independent samples t test, Pearson correlation, and linear and logistic regression.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

et al. 2021

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“…Hence, studies investigating the influence of age and puberty on TBS mostly indicate a strong influence of puberty on bone texture, because TBS starts to rise at the age of puberty initiation. As for the variability of chronological age at puberty onset and the wide range of maturation rates, Guagnelli and colleagues ( 30 ) recently proposed to evaluate TBS in children based on bone age. In their study, a prepubertal decline of TBS values was visible in girls, which disappeared after correction with bone age.…”

Section: Discussionmentioning

confidence: 99%

“…To date, only few studies have analyzed the assessment of TBS in children and adolescents ( 27–33 ) and no pediatric reference data of larger cohorts have been published. New data were presented during international conferences, including mean TBS values for age in a study population of 4127 healthy, typically developing children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Bone Microarchitecture Assessed by Trabecular Bone Score Is Independent of Mobility Level or Height in Pediatric Patients with Cerebral Palsy

Rehberg

Azim

Martakis

et al. 2020

Journal of Bone and Mineral Research

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Bone strength and fracture risk do not only depend on bone density, but also on bone structure. The trabecular bone score (TBS) evaluates homogeneity of bone microarchitecture indirectly by measuring gray‐level variations of two‐dimensional (2D) DXA images. Although TBS is well‐established for adults, there have been only few publications in pediatrics. In this monocentric retrospective analysis, we investigated TBS in children and adolescents with cerebral palsy (CP), a patient group vulnerable to low bone mineral mass due to impaired mobility. The influence of different parameters on TBS and areal BMD (aBMD) were evaluated, as well as the relationship between TBS and aBMD. We compared TBS values of our study population to a reference population. A total of 472 lumbar spine–dual‐energy X‐ray absorptiometry (LS‐DXA) scans of children and adolescents with CP (205 female), aged between 4 and 18 years, were analyzed. The DXA‐scans were part of the routine examination. The children had no records of fractures or specific bone diseases. Our study population with CP had similar TBS as the reference population. TBS did not increase with age until an inflection point at 10 years in females, and 12 years in males. Girls had significantly higher TBS than boys (p = .049) and pubertal girls aged 8 to 13 years had significantly higher TBS than prepubertal girls (p = .009). TBS standard deviation score for age (SDS‐TBS) and aBMD Z‐scores correlated weakly (p < .001; R = 0.276 [males], R = 0.284 [females]). Other than for aBMD Z‐scores, SDS‐TBS was not influenced by age‐adjusted height Z‐scores and there was no significant difference in SDS‐TBS when grouped by mobility levels, using the Gross Motor Function Classification System (GMFCS). Our results indicate that children with CP have a similar homogeneous distribution of trabecular microarchitecture as controls. Puberty initiation appears to be essential for increase of TBS with age and for sex differences. TBS seems less influenced by body composition, height, and mobility than aBMD. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

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“…However, the proportion of risk prediction in a more general osteoporosis approach warrants further studies, and also depends on the software used (TBS iNsight ® , Version 4.0) with a 54% (OR 1.54; 95% CI, 1.18 to 2.00) increase of having a major osteoporotic fracture (MOF) for each standard deviation decline in TBSv4.0 values ( 95 ). Chronological age and TBS are related; significant age-related changes seem to occur with a turning point to higher TBS values at age 8 in girls and age 10 in boys ( 96 ). The use of the TBS has not yet been sufficiently explored or recommended for clinical use in children, (see the current ISCD position at iscd.org/learn/official-positions, last access Dec 2020).…”

Section: Bone Density and Imaging - 2dmentioning

confidence: 99%

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

et al. 2021

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A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

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Bone age as a correction factor for the analysis of trabecular bone score (TBS) in children

Cited by 11 publications

References 30 publications

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

Bone Microarchitecture Assessed by Trabecular Bone Score Is Independent of Mobility Level or Height in Pediatric Patients with Cerebral Palsy

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

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