Bone Age Advancement in Prepubertal Children With Obesity and Premature Adrenarche: Possible Potentiating Factors

Sopher, Aviva B.; Jean, Amy M.; Zwany, Sarah K.; Winston, Diana; Pomeranz, Christy B.; Bell, Jennifer J.; McMahon, Donald J.; Hassoun, Abeer; Fennoy, Ilene; Oberfield, Sharon E.

doi:10.1038/oby.2010.305

Cited by 94 publications

(125 citation statements)

References 30 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…This was found to be less than the study done by Sopher et al where it was found that when all subjects were divided by obesity status, obese subjects were more likely to be in the highest BA/CA centile which is between 1.170 to 1.303 than non-obese subjects. 21 The bone age index and the BMI were compared by using the correlation graph where the Y axis represented the Bone age index and the X axis represented the BMI. It was noted that there was acceleration of bone age index as the BMI progressed.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure is often used in the management and diagnosis of endocrine disorders and it can also serve as an indication of the therapeutic effect of treatment. 13 Generally, it can indicate whether the growth of a patient is accelerating or decreasing. In many cases the decision whether to treat a patient with growth hormones depends on the outcome of this test.…”

Section: Bone Age Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Association of bone age with overweight and obesity in children in the age group of 8 to 11 years

Godfrey

Umapathy

Ravichandran

et al. 2016

Int J Contemp Pediatr

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Bone Age Assessmentmentioning

confidence: 99%

Association of bone age with overweight and obesity in children in the age group of 8 to 11 years

Godfrey

Umapathy

Ravichandran

et al. 2016

Int J Contemp Pediatr

View full text Add to dashboard Cite

“…For example, some studies evaluated the difference between BA and chronological age (CA) [8, 10], whereas others assessed the ratio between these parameters [11], while an age-adjusted indicator would theoretically be superior. Furthermore, some studies included prepubertal children only [6, 10], while others also included pubertal children [5, 7]. Additionally, most studies reported on androgen and oestrogen levels as absolute levels, although these vary significantly with age and pubertal staging, making age an important potential confounder in association studies.…”

Section: Introductionmentioning

confidence: 99%

Determinants of Advanced Bone Age in Childhood Obesity

et al. 2017

View full text Add to dashboard Cite

Background: Childhood obesity is associated with advanced bone age (BA). Previous studies suggest that androgens, oestrogens, sex hormone-binding globulin, and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach. Method: We performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens, oestrogens, and with indicators of insulin secretion derived from oral glucose tolerance testing, in a group of obese children. A multivariate analysis was performed to investigate which parameters were independently predictive of BA SDS. Results: In this cohort (n = 101; mean age 10.9 years; mean BA 11.8 years; mean BMI SDS 3.3), BMI SDS was significantly correlated to BA SDS (r = 0.55, p < 0.001). In a regression analysis in the total cohort (B = 0.27, p < 0.001) as well as in females (B = 0.34, p = 0.042), males (B = 0.31, p = 0.006), and pubertal children (B = 0.32, p = 0.046), dehydroepiandrosterone sulphate (DHEAS) showed a positive, independent association with BA SDS. No association with indicators of insulin secretion was found. Conclusion: BMI SDS is highly correlated to BA SDS in obese children. Increased DHEAS has a central role in advanced BA in obese children.

show abstract

“…As the increase in adrenal androgens precedes the increase in estrogens in girls, adrenarche has been suggested to be involved in inducing puberty (9). Furthermore, children with premature adrenarche may develop secondary central precocious puberty (CPP) (6,10). Adiposity may play a role for the timing of pubarche, and hormones related to body fat (leptin, insulin, and insulin-like growth factor 1) have been suggested to participate in initiation of adrenarche (3,11).…”

Section: Introductionmentioning

confidence: 99%

The pubertal transition in 179 healthy Danish children: associations between pubarche, adrenarche, gonadarche, and body composition

Mouritsen

Aksglæde

Soerensen

et al. 2013

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Pubertal onset is usually defined by breast development in girls and testicular growth in boys. Pubarche is defined as the attainment of pubic hair and is considered as a sign of pubertal transition. Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and D4-androstenedione (Adione), a process termed adrenarche. Objective: To study the natural course of pubertal transition and the associations with adrenarche, body fat, and linear growth. Design and methods: A longitudinal study of 179 healthy children (89 girls) with higher socioeconomic background examined every 6 months for 5 years. Pubic hair stage, breast stage, genital stage, testicular volume (TV), height, weight, and four skinfolds were measured. Results: In girls, median age (25th and 75th percentiles) at thelarche (B2C) was 10.1 years (9.3-10.9). In boys, median age at attaining a TV O3 ml was 11.5 years (10.9-12.0). Median age at pubarche (PH2C) was 10.9 years (10.3-11.4) in girls and 11.6 years (10.8-12.4) in boys. Only 6.8% (4/59) of the girls and 24.6% (15/61) of the boys developed pubic hair as the first isolated sign of puberty. Serum DHEAS and Adione increased with age, although the increase in Adione was most pronounced in girls. No associations between early age at thelarche/testicular growth and increased body fat (BMI and sum of four skinfolds) were observed. Conclusion: Danish children rarely experience pubarche as the first sign of puberty. No associations between age at pubertal onset and body composition were found. Circulating levels of Adione, but not DHEAS, increased with the onset of puberty, although with large interindividual variability.

show abstract

Bone Age Advancement in Prepubertal Children With Obesity and Premature Adrenarche: Possible Potentiating Factors

Cited by 94 publications

References 30 publications

Association of bone age with overweight and obesity in children in the age group of 8 to 11 years

Association of bone age with overweight and obesity in children in the age group of 8 to 11 years

Determinants of Advanced Bone Age in Childhood Obesity

The pubertal transition in 179 healthy Danish children: associations between pubarche, adrenarche, gonadarche, and body composition

Contact Info

Product

Resources

About