Bonding of bone to apatite-coated implants

Geesink, R. G. T.; Groot, K. de; Cp, Klein

doi:10.1302/0301-620x.70b1.2828374

Cited by 476 publications

(228 citation statements)

References 15 publications

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“…However, these opposing processes of bone gain and loss do not work at the same time, but whether they persist and to what degree are unknown. Although short-term retrieval studies report the HA coating after 2 to 4 years implantation is partly broken down through osteoclastic resorption [2,3,5,10,11,18,19,27,28], none of these studies reported whether patient demographics might influence residual HA coating or bone ongrowth. Therefore, we asked three questions: (1) Is the resorption of HA coating and bone ongrowth mainly correlated with time in vivo or with demographics, and when time in vivo is predominant, at which point can we expect all the HA to have completely resorbed?…”

Section: Discussionmentioning

confidence: 99%

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Bone Remodeling and Hydroxyapatite Resorption in Coated Primary Hip Prostheses

Tonino¹,

Wal²,

Heyligers³

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Hydroxyapatite coatings for THA promote bone ongrowth, but bone and coating are exposed to stress shielding-driven osteoclastic resorption. We asked: (1) if the resorption of hydroxyapatite coating and bone ongrowth correlated with demographics; (2) if the resorption related to the stem level; and (3) what happens to the implant-bone interface when all hydroxyapatite coating is resorbed? We recovered 13 femoral components from cadaveric specimens 3.3 to 11.2 years after uneventful primary THA. Three cross sections (proximal, medial, distal) of the hydroxyapatite-coated proximal implant sleeve were analyzed by measuring the percentage of residual hydroxyapatite and bone ongrowth on the implant perimeter. Hydroxyapatite resorption was independent of patient age but increased with time in vivo and mostly was gone after 8 years. Bone ongrowth was independent of time in vivo but decreased with aging patients. Only in the most proximal section did less residual hydroxyapatite correlate with less bone ongrowth. Hydroxyapatite resorption, which was more proximal than distal, showed no adverse effects on the implant-bone interface.

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Section: Discussionmentioning

confidence: 99%

“…The use of hydroxyapatite (HA) has been advocated to provide rapid and reliable attachment of bone to metal implants [4,6,9,10,17,19,21,25,26]. Augmented bone ongrowth has been documented as early as 3 weeks and as persisting for some years [2-4, 11, 26, 27].…”

Section: Introductionmentioning

confidence: 99%

Bone Remodeling and Hydroxyapatite Resorption in Coated Primary Hip Prostheses

Tonino¹,

Wal²,

Heyligers³

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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“…Bonding to living bone occurs over a relatively short period of time even under loaded conditions (Geesink et al 1988, Bauer et al 1991, Hardy et al 1991, Søballe et al 1991, Frayssinet et al 1993, Donnelly et al 1997, Overgaard et al 1997, Tonino et al 1999. We studied an uncemented stem with proximal HA coating designed to load only the proximal part of the femur.…”

mentioning

confidence: 99%

High survival rate of hydroxyapatite-coated hip prostheses100 consecutive hips followed for 10 years

Oosterbos¹,

Rahmy

Tonino

et al. 2004

Acta Orthopaedica Scandinavica

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“…Numerous deposition techniques exist for BAp membranes, such as plasma spray 15) and sputter 16) . The advantage of the PLD technique is that the composition of the membrane and the target is similar, i.e., the source of prepared membrane.…”

Section: Discussionmentioning

confidence: 99%

A novel membrane-type apatite scaffold engineered by pulsed laser ablation

et al. 2015

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Cell sheet technology is a scaffold-free method for tissue reconstruction. A sheet-shaped scaffold would be suitable for the regeneration of periodontal membrane. We designed a stem cell sheet combining human mesenchymal stromal cells (hMSCs) and a 10-µm thick biological apatite (BAp) membrane fabricated with an ArF pulsed laser ablation for periodontal regeneration. X-ray diffraction showed that crystalline hydroxyapatite (HAp) was present in BAp and HAp membranes after post-annealing. Energy dispersive analysis of the BAp membrane revealed peaks of Na and Mg in addition to Ca and P. Approximately 3×10 4 hMSCs were cultured on BAp and HAP membranes for 7 and 14 days. From in vitro assays, hMSCs grew faster and had higher osteoblast differentiation when cultured on the BAp membrane than did the cell culture on the HAp membrane. Stem cell sheets combined with a BAp membrane may have potential applications in guided bone regeneration and osteoconductive scaffolds.

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Bonding of bone to apatite-coated implants

Abstract: Implants

Cited by 476 publications

References 15 publications

Bone Remodeling and Hydroxyapatite Resorption in Coated Primary Hip Prostheses

Bone Remodeling and Hydroxyapatite Resorption in Coated Primary Hip Prostheses

High survival rate of hydroxyapatite-coated hip prostheses100 consecutive hips followed for 10 years

A novel membrane-type apatite scaffold engineered by pulsed laser ablation

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