Bombay Blood Group Phenotype Misdiagnosed As O Phenotype: A Case Report

Abstract

Bombay blood group is a rare type that was initially identified in the city of Bombay, India. It is characterized by the presence of serum antibodies anti-A, anti-B, and anti-H, which can cause agglutination in all blood groups within the ABO system. The clinical importance of the Bombay blood group lies in its inability to receive transfusions from other blood groups. In this case report, we present a case of a young male who was initially misdiagnosed as having an O phenotype, resulting in a hemolytic transfusion reaction. This case highlights the diagnostic and therapeutic challenges associated with rare blood phenotypes.

Bombay Blood Group: Case Series

“…Therefore, it is extremely important to identify this blood group because the clinically significant anti-H antibodies produced can result in an acute hemolytic transfusion reaction, which can manifest as disseminated intravascular coagulation or acute renal failure and can be fatal [ 7 ]. Moreover, these individuals can only be transfused with blood products from donors of the same blood group, and finding a donor when needed is challenging due to the rarity of this phenotype [ 8 ]. Under-reporting and non-maintenance of registries of correctly diagnosed cases also contribute to the lack of availability of suitable donors.…”