Bombax Costatum extract abrogates piroxicam-mediated hepatic and gastric toxicities in rats

Oraebosi, Michael Ikechukwu; Good, Gonaka M; Chia, Terkuma; Oyeniran, Oluwatosin Imoleayo

doi:10.1016/j.pharma.2020.06.002

Cited by 8 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to [13] shows preparing the next generation of African Healthcare Workers and Scientists: In this work, we have developed a search ranked system based on hierarchical clustering and shown that the techniques can improve system usability and efficiency. Depending on the objective, clustering can be performed either before the search to cluster similar documents or after the search to cluster similar results.…”

Section: Related Workmentioning

confidence: 99%

Development of an Internet-Based Information/DataResource Platform during the COVID-19 Pandemic Using Hierarchical Clustering

Evelyn¹,

Owolabi²,

Ubaka³

et al. 2022

IJASRE

View full text Add to dashboard Cite

there is heavy usage of Internet-based information resource platformsdue to the COVID-19 pandemic. If it can present the search results as a list of groupsof related terms and context, that would be ideal. An additional enhancement would be to display information in the search results in a classified manner. Therefore, the research is proposing an effective and efficient information retrieval system. The methodology adopted follows the conventional Information Retrieval (IR) system design except that Cosine similarity and hierarchical clustering were introduced for search result ranking. The Average Precision of the proposed system was compared with that of flat clustering such as K-means. The result of the evaluation shows that hierarchical clustering improved in precision, being10% better than flat clustering result retrieval result. This led to greater usability, userexperience,and efficiency of the system.

show abstract

Section: Related Workmentioning

confidence: 99%

Development of an Internet-Based Information/DataResource Platform during the COVID-19 Pandemic Using Hierarchical Clustering

Evelyn¹,

Owolabi²,

Ubaka³

et al. 2022

IJASRE

View full text Add to dashboard Cite

show abstract

“…The obtained serum was used to determine levels of hepatic markers [aspartate aminotransferase (AST), total bilirubin (TB), alkaline phosphatase (ALP), and alanine aminotransferase (ALT)] and oxidative stress level [superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT), with lipid peroxidation product, malondialdehyde (MDA)] using protocols described in the kits (Randox Laboratories Ltd., UK) as adopted previously. 16 Carbon tetrachloride-induced hepatotoxocity A protocol earlier proposed was adopted. 6 Thirty rats were shared equally into six groups.…”

Section: Paracetamol Toxicity Modelmentioning

confidence: 99%

“…Serum hepatic markers with antioxidant profile (similar to paracetamol model) were assessed using description it the kits (Randox Laboratories Ltd., Ardmore, UK) as previously adopted. 16 Liver histology At the end of paracetamol induced-toxicity model, the liver of the rats were excised and preserved as previously described. 17 The liver tissues were dehydrated through varying concentration of ethanol and thereafter embedded in paraffin.…”

Section: Paracetamol Toxicity Modelmentioning

confidence: 99%

Hepatoprotective Effect of Andropogon gayanus against Paracetamol- and Carbon Tetrachloride-Induced Liver Toxicity in Rats

2021

TJNPR

View full text Add to dashboard Cite

The liver is one of the principal organs in the body and is involved in synthesis, metabolism, storage and detoxification. 1 It's role in the metabolism of xenobiotics makes it particularly susceptible to severe toxicities which are often in form of circulatory, neoplastic, and microbial insults. 2,3 Diseases of the liver are widespread and lead to a lot of deaths worldwide. These diseases are predominantly hepatitis due to viral infections, alcohol-mediated liver injury, liver cirrhosis and liver cells carcinoma. 3,4 Adequate therapeutic measures are hence required to reduce the incidence and associated deaths. Orthodox drugs available for the management of liver diseases usually predispose to adverse effects especially after prolonged use. 5 In addition, due to high cost; they are often not easily accessed by rural dwellers. 6 Hence, newer therapeutic options that are more accessible and affordable with fewer side effects have been sought for by studying medicinal plants. 6,7 Andropogon gayanus Kunth also known as Gamba grass in English is a widely accessible and used plant medicine of the Poaceae family. It is a nutritive forage 8 locally known as Gamba or Tsaure and Eruwa ako among the Hausa and Yourba natives of Nigeria respectively.

show abstract

Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats

Oraebosi

Olurishe

Anafi

et al. 2022

Annales Pharmaceutiques Françaises

View full text Add to dashboard Cite

Bombax Costatum extract abrogates piroxicam-mediated hepatic and gastric toxicities in rats

Cited by 8 publications

References 20 publications

Development of an Internet-Based Information/DataResource Platform during the COVID-19 Pandemic Using Hierarchical Clustering

Development of an Internet-Based Information/DataResource Platform during the COVID-19 Pandemic Using Hierarchical Clustering

Hepatoprotective Effect of Andropogon gayanus against Paracetamol- and Carbon Tetrachloride-Induced Liver Toxicity in Rats

Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats

Contact Info

Product

Resources

About