“…Cimetidine, 4 mg/kg in adults, should be administered slowly because rapid intravenous administration might produce hypotension. 58 Cimetidine should not be administered to children with anaphylaxis because no dosages have been established.…”
Section: Management Of Anaphylaxismentioning
confidence: 99%
“…B A few drugs might elicit IgEmediated reactions without first combining with a carrier protein. 58. Penicillin is the most common cause of drug-induced anaphylaxis.…”
Section: In Most Cases Low-molecular-weight Medicationsmentioning
“…Cimetidine, 4 mg/kg in adults, should be administered slowly because rapid intravenous administration might produce hypotension. 58 Cimetidine should not be administered to children with anaphylaxis because no dosages have been established.…”
Section: Management Of Anaphylaxismentioning
confidence: 99%
“…B A few drugs might elicit IgEmediated reactions without first combining with a carrier protein. 58. Penicillin is the most common cause of drug-induced anaphylaxis.…”
Section: In Most Cases Low-molecular-weight Medicationsmentioning
“…Three other studies [81-831 reported a fall in blood pressure and a possibly reactive rise in heart rate following intravenous administration of cimetidine while ranitidine did not produce these changes. As an example, a fall in blood pressure without occurrence of reflex tachycardia [82] is shown in Fig. 2.…”
Section: Description Of Investigations Perjormedmentioning
confidence: 99%
“…Several of the investigations were performed on patients in intensive care units [75,79,8 1-85] being concurrently treated with other drugs affecting the cardiovascular parameters under consideration. For example, catecholamines or other vasoactive substances were administered to patients in some of these studies [79,81,82,85]. In other investigations, only partial information about concomitant treatment in these critically ill patients was presented [75,83].…”
Section: Critical Considerations Concerning Hi Blocker Clinical S T Umentioning
“…A decrease in blood pressure after intravenous cimetidine administration has been noted most frequently.82. [85][86][87][88][89] In some studies, the decrease in blood pressure induced by cimetidine was accompanied by an increase in heart rate. 8S.88 For the newer Hj-receptor antagonist nizatidine, a marked negative chronotropic effect could be demonstrated.l'P"?'…”
Section: Description Of Investigations Performedmentioning
In vitro studies and animal experiments as well as clinical observations in humans concerning cardiovascular effects of H2-receptor antagonists have been published shortly after the development. Thus, clinical studies were performed to investigate these effects. The following review summarizes the results from in vitro studies up to the clinical investigations performed.
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