Bolus Geometry and Dynamics after Intravenous Injection of Contrast Media

Claussen, Claus D.; Félix, R.

doi:10.1007/978-3-642-68957-4_35

Radiological Functional Analysis of the Vascular System 1983

DOI: 10.1007/978-3-642-68957-4_35

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Bolus Geometry and Dynamics after Intravenous Injection of Contrast Media

Claus D. Claussen

R. Félix

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1997

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“…PARAMAGNETIC CONTRAST AGENTS administered as a sharp bolus during fast T2*-sensitive MRI produce a regional signal drop in brain tissue corresponding to vascular perfusion (1)(2)(3). This technique, which is based on susceptibility changes in the capillary network during bolus passage, allows one to distinguish between tissues with differing blood flow (4)(5)(6). Therefore, bolus tracking of an intravascular paramagnetic contrast agent is considered a sensitive method for depiction of focal cerebral ischemia, even early after vessel occlusion (7-101, when standard MRI (ie.…”

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Perfusion‐weighted MRI using gadobutrol as a contrast agent in a rat stroke model

Heiland

Benner

Reith

et al. 1997

Magnetic Resonance Imaging

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The purpose of this study was to examine the new nonionic contrast agent gadobutrol in MR perfusion-weighted imaging, including the influence of different concentrations and dosages of the agent on the sensitivity to perfusion alterations. Sixteen rats were examined within 35 to 105 minutes after endovascular occlusion of the middle cerebral artery. A fast T2*-weighted fast low-angle shot (FLASH) sequence was used to acquire four images before and 16 images after bolus injection of .1, .2, .3, and .4 mmol/kg gadobutrol as .5 molar and 1.0 molar formulation. From user-defined regions, we obtained the maximum signal decrease, the relative regional cerebral blood volume, and the bolus delay. Contrast between ischemic and nonischemic regions during bolus passage increased with dose and concentration of the contrast agent. For low doses (.1 and .2 mmol/kg), the ischemic lesion could not or could barely be discerned. For higher doses (.3 and .4 mmol/kg), administration of the 1 molar contrast agent yielded a better contrast between ischemic and nonischemic tissue. Our results suggest that administration of gadobutrol at higher dosage and higher concentration increases sensitivity to perfusion alterations. These results are potentially useful for perfusion-weighted imaging of the human brain, because the volume of contrast agent will be reduced if a solution with higher concentration is used. When using contrast agents in higher concentrations for human examinations, a significant signal decrease may be achieved also with the low doses (.1-.15 mmol/kg).

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mentioning

confidence: 99%

Perfusion‐weighted MRI using gadobutrol as a contrast agent in a rat stroke model

Heiland

Benner

Reith

et al. 1997

Magnetic Resonance Imaging

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Bolus Geometry and Dynamics after Intravenous Injection of Contrast Media

Cited by 1 publication

References 4 publications

Perfusion‐weighted MRI using gadobutrol as a contrast agent in a rat stroke model

Perfusion‐weighted MRI using gadobutrol as a contrast agent in a rat stroke model

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