Boldine and Related Aporphines: From Antioxidant to Antiproliferative Properties

Muthná, Darina; Ćmielová, Jana; Tomšík, Pavel; Řezáčová, Martina

doi:10.1177/1934578x1300801235

Cited by 17 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9][10][11][12] Boldine structurally belongs to the aporphine alkaloids. 13,14 These chemicals are wellknown for their antioxidant and radical scavenging activities. 10,13,14 Several pharmacological actions including anti-inflammatory, immunomodulatory, antidiabetic, cytoprotective, and cardiovascular protecting properties have been attributed to boldine.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 These chemicals are wellknown for their antioxidant and radical scavenging activities. 10,13,14 Several pharmacological actions including anti-inflammatory, immunomodulatory, antidiabetic, cytoprotective, and cardiovascular protecting properties have been attributed to boldine. [15][16][17][18] Hence, this alkaloid could serve as a potential therapeutic molecule against oxidative stress-mediated injury of biological systems.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity

et al. 2019

View full text Add to dashboard Cite

Background: The xenobiotics-induced liver injury is a clinical complication. Hence, finding new hepatoprotective strategies has clinical value. Oxidative stress and its subsequent complications are major mechanisms involved in xenobiotics-induced hepatotoxicity. Boldine is one of the most potent antioxidant molecules widely investigated for its protective properties in different experimental models. In the current study, the hepatoprotective properties of boldine and its potential mechanisms of hepatoprotection have been investigated. Methods: Rats received thioacetamide (TAA; 200 mg/kg, i.p) as a model of acute liver injury. Boldine (5, 10, 1nd 20 mg/kg; 24 hours intervals; oral) was administered as the hepatoprotective agent. Results: Liver injury was evident in TAA-treated animals (48 hours after TAA exposure) as a severe increase in serum level of liver injury biomarkers and histopathological alterations. Moreover, markers of oxidative stress were increased in liver tissue of TAA-treated rats. Assessment of mitochondrial indices of functionality revealed a significant decrease in mitochondrial dehydrogenases activity, the collapse of mitochondrial membrane potential, mitochondrial swelling and depletion of ATP content. It was found that boldine supplementation mitigated liver tissue markers of oxidative stress and improved mitochondrial indices of functionality in TAA-treated animals. Conclusion: The hepatoprotective properties of boldine might primarily rely on antioxidant and mitochondria protecting effects of this alkaloid.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, boldine is a strong anti-oxidant and supposed to prevent ultraviolet mediated DNA damage [28,29]. Therefore, apoptosis induction by boldine that was observed only at high concentrations is probably explained with its pro-oxidant properties at high doses [30,31].…”

Section: Resultsmentioning

confidence: 99%

Dose-Dependent Cytotoxic Effects of Boldine in HepG-2 Cells—Telomerase Inhibition and Apoptosis Induction

Noureini

2015

Molecules

View full text Add to dashboard Cite

Plant metabolites are valuable sources of novel therapeutic compounds. In an anti-telomerase screening study of plant secondary metabolites, the aporphine alkaloid boldine (1,10-dimethoxy-2,9-dihydroxyaporphine) exhibited a dose and time dependent cytotoxicity against hepatocarcinoma HepG-2 cells. Here we focus on the modes and mechanisms of the growth-limiting effects of this compound. Telomerase activity and expression level of some related genes were estimated by real-time PCR. Modes of cell death also were examined by microscopic inspection, staining methods and by evaluating the expression level of some critically relevant genes. The growth inhibition was correlated with down-regulation of the catalytic subunit of telomerase (hTERT) gene (p < 0.01) and the corresponding reduction of telomerase activity in sub-cytotoxic concentrations of boldine (p < 0.002). However, various modes of cell death were stimulated, depending on the concentration of boldine. Very low concentrations of boldine over a few passages resulted in an accumulation of senescent cells so that HepG-2 cells lost their immortality. Moreover, boldine induced apoptosis concomitantly with increasing the expression of bax/bcl2 (p < 0.02) and p21 (p < 0.01) genes. Boldine might thus be an interesting candidate as a potential natural compound that suppresses telomerase activity in non-toxic concentrations.

show abstract

“…Over the last few decades, several reviews covering the pharmacological activities of aporphines such as their antioxidant [8], cytotoxic [9][10][11][12], antiviral, antibacterial, and antifungal properties [13] as well as their dopaminergic, noradrenergic, and serotonergic activities [14][15][16] have been published. Additionally, the potent free radical scavenger properties of S-(+)-boldine (1) (Figure 1) and its numerous pharmacological activities have been reviewed [17,18]. Moreover, aporphine alkaloids have served as leads for the development of potential pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities

Ali

Cuny

2021

Molecules

View full text Add to dashboard Cite

Aporphines, a major group of aporphinoid alkaloids, exhibit interesting and diverse pharmacological activities. A set of dimeric aporphines with an aryloxy group at C8, C9, and C11 have been isolated from six genera and shown to elicit various biological activities such as antitumor, antimalarial, antimicrobial, antiplatelet aggregation, antifibrotic, immunosuppressive, and vasorelaxant properties. In this review, the nomenclature, chemical structures, botanical sources, pharmacological activities, and synthetic approaches of this set of dimeric alkaloids are presented.

show abstract

Boldine and Related Aporphines: From Antioxidant to Antiproliferative Properties

Cited by 17 publications

References 39 publications

Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity

Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity

Dose-Dependent Cytotoxic Effects of Boldine in HepG-2 Cells—Telomerase Inhibition and Apoptosis Induction

8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities

Contact Info

Product

Resources

About