Bok choy (Brassica rapa) grown in copper oxide nanoparticles-amended soils exhibits toxicity in a phenotype-dependent manner: Translocation, biodistribution and nutritional disturbance

Deng, Chaoyi; Wang, Yi; Cota-Ruíz, Keni; Reyes, Andres; Sun, Youping; Peralta-Videa, José R.; Hernández-Viezcas, José Á.; Turley, R. Steven; Niu, Genhua; Li, Chunqiang; Gardea‐Torresdey, Jorge L.

doi:10.1016/j.jhazmat.2020.122978

Cited by 52 publications

(28 citation statements)

References 55 publications

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“…In a recent study using cowpea, Ogunkunle et al [ 69 ] found a linear concentration response upon exposure to CuNPs (<25 nm and 60–80 nm) for Cu uptake by root, a finding consistent with our results. Deng et al [ 70 ] found the highest Cu concentration in Brassica rapa var. Rosie treated with 600 mg/kg of CuONPs, with roots containing up to ~479 mg Cu/kg dry weight.…”

Section: Resultsmentioning

confidence: 99%

“…Cu bioaccumulation in cowpea leaves was also enhanced by CuNPs with sizes < 25 nm and 60–80 nm; however, increasing exposure concentrations led to decreased translocation [ 69 ], suggesting a threshold for NP uptake and translocation in plants. Deng et al most recently reported that the leaf Cu accumulation pattern of Brassica rapa treated with CuONPs (75, 150, 300, and 600 mg Cu/kg soil) was dependent on particle size and plant phenotype [ 70 ]. Our findings suggest that CuONPs with a small size (25 nm) could be more favored for cellular entry and translocation compared to larger-sized CuONPs, promoting leaf Cu uptake in soybeans.…”

Section: Resultsmentioning

confidence: 99%

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Root System Architecture, Copper Uptake and Tissue Distribution in Soybean (Glycine max (L.) Merr.) Grown in Copper Oxide Nanoparticle (CuONP)-Amended Soil and Implications for Human Nutrition

Yusefi-Tanha

Fallah

Rostamnejadi

et al. 2020

Plants

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Understanding the potential uptake and biodistribution of engineered nanoparticles (ENPs) in soil-grown plants is imperative for realistic toxicity and risk assessment considering the oral intake of edibles by humans. Herein, growing N-fixing symbiont (Bradyrhizobium japonicum) inoculated soybean (Glycine max (L.) Merr.) for a full lifecycle of 120 days, we assessed the potential influence of particle size (25, 50, and 250 nm) and concentration (0, 50, 100, 200, and 500 mg/kg soil) of Copper oxide nanoparticles (CuONPs) on: (1) root system architecture, (2) soil physicochemical attributes at the soil–root interface, and (3) Cu transport and accumulation in root, stem, leaf, and seed in soybean, and compared them with the soluble Cu2+ ions and water-only controls. Finally, we performed a comparative assessment of total seed Cu levels in soybean with other valuable food sources for Cu intake and discussed potential human health implications. Results showed particle size- and concentration-dependent influence of CuONPs on Cu uptake and distribution in root, stem, leaf, and seed. Alterations in root architecture (root biomass, length, volume, and area) were dependent on the Cu compound types, Cu concentrations, and their interactions. Concentration–response relationships for all three sizes of CuONPs and Cu2+ ions were found to be linear. Furthermore, CuONPs and Cu2+ ions had inhibitory effects on root growth and development. Overall, soybean responses to the smallest size of CuONPs–25 nm—were greater for all parameters tested compared to the two larger-sized CuONPs (50 nm, 250 nm) or Cu2+ ions. Results suggest that minor changes in soil-root physicochemical attributes may not be a major driver for Cu uptake in soybean. Cu bioaccumulation followed the order: root > leaf > stem > seed. Despite reduction in root architecture and seed yield, the smallest size CuONPs–25 nm led to increased total seed Cu uptake compared to the larger-sized CuONPs or Cu2+ ions. Our findings also suggest that soil amendment with CuONPs, and more so with the smallest size of CuONPs–25 nm—could significantly improve seed nutritional Cu value in soybean as reflected by the % Daily Values (DV) and are rated “Good” to “Very Good” according to the “World’s Healthiest Foods” rating. However, until the potential toxicity and risk from CuONP-fortified soybean seed ingestion is characterized in humans, we caution recommending such seeds for daily human consumption when addressing food Cu-deficiency and associated diseases, globally.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Root System Architecture, Copper Uptake and Tissue Distribution in Soybean (Glycine max (L.) Merr.) Grown in Copper Oxide Nanoparticle (CuONP)-Amended Soil and Implications for Human Nutrition

Yusefi-Tanha

Fallah

Rostamnejadi

et al. 2020

Plants

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“…Cu bioaccumulation in cowpea leaf was also enhanced by CuNPs with sizes < 25 nm and 60-80 nm; however, increasing exposure concentrations led to decreased translocation (Ogunkunle et al, 2018), suggesting a threshold for NP uptake and translocation in plants. Deng et al (2020) also reported that leaf Cu accumulation pattern of Brassica rapa treated with nano CuO (75, 150, 300, and 600 mg Cu/kg soil) depends on particle size and plant phenotype. Our findings suggest that CuONPs with small size (25 nm) may be favored for cellular entry and translocation compared to the larger size CuONPs, promoting increase in leaf Cu uptake in soybean.…”

Section: Leaf Copper Uptakementioning

confidence: 89%

Root System Architecture, Copper Uptake and Tissue Distribution in Soybean (Glycine max cv. Kowsar) Grown in Copper Oxide Nanoparticles (CuONPs) Amended Soil and Implications to Human Nutrition

Yusefi-Tanha¹,

Fallah²,

Rostamnejadi³

et al. 2020

Preprint

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Understanding potential uptake and biodistribution of engineered nanoparticles in soil-grown plants is imperative for toxicity and risk assessment considering the oral exposure of edibles by humans. Herein, we assessed potential influence of particle size (25, 50, and 250 nm) and concentration (0, 50, 100, 200, and 500 mg/kg-soil) of Copper oxide nanoparticles (CuONPs) on: (1) the root system architecture, and the physicochemical attributes of soil at the soil-root interface, (2) leading to Cu transport and accumulation in root, stem, leaf and seed in soybean (Glycine max cv Kowsar) grown for entire lifecycle of 120 days, and compared with soluble Cu2+ ions and water-only controls, and (3) performed a comparative assessment of total seed Cu levels in soybean with other valuable food sources for Cu intake and discussed its human health implications. Our findings showed particle size- and concentration-dependent influence of CuONPs on Cu uptake and tissue distribution in root, stem, leaf and seed in soybean. Alterations in root architecture (root dry weight, root length, root volume, and root area) were dependent on the Cu compound type, Cu concentrations, and their interactions (p<0.05), except for root density. Concentration-response relationships for all three sized CuONPs, and Cu2+ ions, were linear. CuONPs and Cu2+ ions had inhibitory effects on root growth and development. Overall, soybean responses to smallest size CuONPs-25 nm were higher for all parameters investigated compared to two larger sized CuONPs (50 nm, 250 nm) or Cu2+ ions. Cu uptake/bioaccumulation differed among soybean tissues in the order: root > leaf > stem > seed. Despite reduced root architecture and seed yield, our smallest size CuONPs-25 nm led to increased total seed Cu uptake compared to the larger sized CuONPs and Cu2+ ions tested. Our findings also suggest that soil amendment by CuONPs, more so by the smallest size CuONPs-25 nm, could significantly improve nutritional Cu value in soybean seed as reflected by % Daily Values (DV), and are rated “Good” to “Very Good” according to the “World’s Healthiest Foods” rating. However, until the potential toxicity and risk from consumption of soybean seed is characterized in humans, caution should be exercised when the Cu fortified seeds are used for daily human consumption when addressing Cu deficiency and associated illnesses, globally.

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“…The engineered-NPs could be directly applied for human as food additives or food industry ( Deng et al, 2021 ) like colorants, emulsifiers, flavor enhancers, artificial sweeteners, foaming and anti-foaming agents ( Medina-Reyes et al, 2020 ). The nanoparticles also in form of silver (Ag), titanium oxide (TiO2) and zinc oxide (e.g., Ag-NPs, TiO 2 -NPs and ZnO-NPs) could be utilized in packaging of foods as antimicrobial agents ( Deng et al, 2020 , Deng et al, 2020 ). Although many nanoparticles have been applied as nano-fertilizers or nano-pesticides, which promote crop productivity, but might cause some problems in soil-plant interfaces particularly the over-doses ( Ragab and Saad-Allah, 2020 ).…”

Section: Nutrients Based Nanoparticles In Edible Plants For Human Healthmentioning

confidence: 99%

“… Targeted plant (scientific name) Applied nano-dose Nutrient forms (preparing type) Growth media (applied method) Main findings References Bell pepper ( Capsicum annuum L.), var. Kitrino Cu-NPs at 100 and 500 mg L −1 Cu-NPs (50 nm, chemical) Bags contained mixture peat and perlite in (1:1) Cu-NPs increased the content of fruit bioactive compounds (flavonoids, carotene, carotenoids) under saline stress González-García et al (2021) Alfalfa ( Medicago sativa L.) 80 and 280 mg Cu kg −1 soil Cu(OH) 2 and Nano-Cu(OH) 2 (chemical) Pot experiment Nano-Cu is considered nano-fertilizer improving physiology of alfalfa Cota-Ruiz et al (2020) Rosie and green bok choy ( Brassica rapa ) 75, 150, 300, and 600 mg Cu kg −1 soil Bulk CuO and CuO-PNs (chemical) Pot experiment filled with soil Cu-distribution patterns depends on size in parenchyma and leaf midrib Deng et al, 2020 , Deng et al, 2020 Wheat ( Triticum aestivum L.) var. Galaxy From 25 to 100 mg kg −1 soil Cu-NPs (17–38 nm biological) Pot experiment filled with soil Green Cu-NPs-based tool is sustainable way to grow wheat in metal-polluted soils Noman et al (2020) Lettuce ( Lactuca sativa L.) From 0.2 to 300 mg L −1 CuO-NPs (~6.6 nm, biological) Petri dishes Low concentrations (≤20 mg l −1 ) of CuO- NPs enhanced plant growth Pelegrino et al (2020) Maize ( Zea mays L.) From 10 to 1000 mg L −1 Cu Cu(OH) 2 and Nano-Cu(OH) 2 (chemical) Petri dishes At 10 ppm nano-Cu can enhance defense system of maize Valdes et al (2020) Soybean ( G. max L.…”

Section: Nano-biofortification For Human Healthmentioning

confidence: 99%

Nano-biofortification of different crops to immune against COVID-19: A review

El-Ramady

Abdalla

Elbasiouny

et al. 2021

Ecotoxicology and Environmental Safety

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Human health and its improvement are the main target of several studies related to medical, agricultural and industrial sciences. The human health is the primary conclusion of many studies. The improving of human health may include supplying the people with enough and safe nutrients against malnutrition to fight against multiple diseases like COVID-19. Biofortification is a process by which the edible plants can be enriched with essential nutrients for human health against malnutrition. After the great success of biofortification approach in the human struggle against malnutrition, a new biotechnological tool in enriching the crops with essential nutrients in the form of nanoparticles to supplement human diet with balanced diet is called nano-biofortification. Nano biofortification can be achieved by applying the nano particles of essential nutrients (e.g., Cu, Fe, Se and Zn) foliar or their nano-fertilizers in soils or waters. Not all essential nutrients for human nutrition can be biofortified in the nano-form using all edible plants but there are several obstacles prevent this approach. These stumbling blocks are increased due to COVID-19 and its problems including the global trade, global breakdown between countries, and global crisis of food production. The main target of this review was to evaluate the nano-biofortification process and its using against malnutrition as a new approach in the era of COVID-19. This review also opens many questions, which are needed to be answered like is nano-biofortification a promising solution against malnutrition? Is COVID-19 will increase the global crisis of malnutrition? What is the best method of applied nano-nutrients to achieve nano-biofortification? What are the challenges of nano-biofortification during and post of the COVID-19?

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Bok choy (Brassica rapa) grown in copper oxide nanoparticles-amended soils exhibits toxicity in a phenotype-dependent manner: Translocation, biodistribution and nutritional disturbance

Cited by 52 publications

References 55 publications

Root System Architecture, Copper Uptake and Tissue Distribution in Soybean (Glycine max (L.) Merr.) Grown in Copper Oxide Nanoparticle (CuONP)-Amended Soil and Implications for Human Nutrition

Root System Architecture, Copper Uptake and Tissue Distribution in Soybean (Glycine max (L.) Merr.) Grown in Copper Oxide Nanoparticle (CuONP)-Amended Soil and Implications for Human Nutrition

Root System Architecture, Copper Uptake and Tissue Distribution in Soybean (<em>Glycine max </em>cv.<em> Kowsar</em>) Grown in Copper Oxide Nanoparticles (CuONPs) Amended Soil and Implications to Human Nutrition <strong> </strong>

Nano-biofortification of different crops to immune against COVID-19: A review

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