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Gribnau, F. W. J.; Zeeuw, Rokus A. de; Brouwers, J. R. B. J.; Kelder, A. J.; Kind, L. A. P. De; Geugten, Jolien van der; Smithuis, L. O. M. J.; Sitsen, J. M. A.; Jonkers, J. R.

doi:10.1007/bf02273291

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“…The ACC was calculated from the test results for three tablets or the equivalent amount of antacid suspension. For additional simulation of the in vivo conditions, the products were tested by a modified Schaub-method (Brouwers, 1975). Before testing, the chewing tablets were crushed into three different sizes: 105,210-300 and 1400-2800pm.…”

Section: In Vitro Testsmentioning

confidence: 99%

Biopharmaceutical properties of liquid and tablet antacids: in vivo studies using the intragastric pH-measurement technique

Brouwers

Tytgat

1978

Journal of Pharmacy and Pharmacology

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Three types of liquid and tablet antacids have been studied in vitro and in vivo: aluminium hydroxide, aluminium hydroxide‐magnesium carbonate and hydrotalcite. The effects on gastric pH of antacid suspensions and antacid chewing tablets having identical active ingredients have been studied in 36 volunteers, the sequence of both forms of administration being randomized. Gastric acid secretion was continuously stimulated during the experiment by a pentagastrin infusion. Antacid chewing tablets gave inferior results when compared with the same antacid in liquid. Antacid suspensions are therefore preferred in the treatment of acid‐peptic disease.

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Section: In Vitro Testsmentioning

confidence: 99%