Body weight and prandial variation of plasma metabolites in subjects undergoing gastric band-induced weight loss

BRUNO, JOANNE; Verano, Michael; Vanegas, Sally M.; Weinshel, Elizabeth; Fielding, Christine Ren; Lofton, Holly; Fielding, George; Schwack, Bradley; Chua, Deborah L.; Wang, Chan; Li, Huilin; Alemán, José O.

doi:10.1016/j.obmed.2022.100434

Cited by 1 publication

(2 citation statements)

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“…Note that a full list of all of the articles supported through this center is included within the reference section. 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 Figure 3 summarizes the center's key accomplishments.…”

Section: Obesity Sfrns : Goals and Resultsmentioning

confidence: 99%

“…In this context, plasma metabolomics analyses indicate a reduction in circulating concentrations of ceramides in all subjects undergoing sleeve gastrectomy, which was more pronounced in patients without diabetes. The research team is comparing the observed metabolomic signatures with the analyses from other recently completed bariatric surgery cohorts analyzed by the New York University center, 36 as well as in TRF interventions, which are being performed in collaboration with the Johns Hopkins University center.…”

Section: Obesity Sfrns : Goals and Resultsmentioning

confidence: 99%

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Obesity and Overweight: Probing Causes, Consequences, and Novel Therapeutic Approaches Through the American Heart Association's Strategically Focused Research Network

Clark

Garvey

Niswender

et al. 2023

JAHA

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As the worldwide prevalence of overweight and obesity continues to rise, so too does the urgency to fully understand mediating mechanisms, to discover new targets for safe and effective therapeutic intervention, and to identify biomarkers to track obesity and the success of weight loss interventions. In 2016, the American Heart Association sought applications for a Strategically Focused Research Network (SFRN) on Obesity. In 2017, 4 centers were named, including Johns Hopkins University School of Medicine, New York University Grossman School of Medicine, University of Alabama at Birmingham, and Vanderbilt University Medical Center. These 4 centers were convened to study mechanisms and therapeutic targets in obesity, to train a talented cadre of American Heart Association SFRN‐designated fellows, and to initiate and sustain effective and enduring collaborations within the individual centers and throughout the SFRN networks. This review summarizes the central themes, major findings, successful training of highly motivated and productive fellows, and the innovative collaborations and studies forged through this SFRN on Obesity. Leveraging expertise in in vitro and cellular model assays, animal models, and humans, the work of these 4 centers has made a significant impact in the field of obesity, opening doors to important discoveries, and the identification of a future generation of obesity‐focused investigators and next‐step clinical trials. The creation of the SFRN on Obesity for these 4 centers is but the beginning of innovative science and, importantly, the birth of new collaborations and research partnerships to propel the field forward.

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