Body weight and maximal acid outputPart of the work was supported by a grant from TNMC and BYL Nair Charitable Hospital Research Society.

Desai, H G; Zaveri, M. P.; Antia, F. P.

doi:10.1136/pgmj.48.556.87

Cited by 5 publications

(3 citation statements)

References 19 publications

(13 reference statements)

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“…Hume and Melrose (1967) showed a significant correlation with lean body mass. This was confirmed more recently by Desai, Zaveri, and Antia (1972) with body weight in controls.Duodenal ulcers have been found to occur more frequently in persons with blood group 0 (Aird, Bentall, Mehigan, and Roberts, 1954) and cigarette smoking is often said to retard ulcer healing (Doll, Jones, and Pygott, 1958). The purpose of this paper is to re-examine the relationship between gastric acid 'Requests for reprints to be sent to: Dr B.…”

supporting

confidence: 75%

“…Hume and Melrose (1967) showed a significant correlation with lean body mass. This was confirmed more recently by Desai, Zaveri, and Antia (1972) with body weight in controls.…”

supporting

confidence: 75%

“…The correlation between peak acid output and body weight (and lean body mass) was later confirmed by Baron (1969) in restudying a combination of data in two groups of normal subjects and patients with ulcers. Desai et al (1972) in India have also recently shown a significant correlation at the 5 % level between body weight and MAO in 40 control males. Card and Marks (1960) showed that the maximal acid output is directly related to the parietal cell mass and suggested that the lower acid output in women appeared to be a reflection of their smaller stature and thus of a smaller parietal cell mass.…”

Section: Resultsmentioning

confidence: 87%

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The relation between gastric acid secretion and body habitus, blood groups, smoking, and the subsequent development of dyspepsia and duodenal ulcer

Novis¹,

Marks²,

Bank³

et al. 1973

Gut

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SUMMARY One hundred and seventy-six students free of gastrointestinal disease were studied to establish normal acid secretion values for healthy male and female students by the augmented histamine test and to re-examine the relationship between gastric acid secretion and ABO blood groups, body weight, fat-free body mass, height, degree of ectomorphy and mesomorphy, the number of cigarettes smoked per day, and serum cholesterol. A prospective study was then carried out on gastric acid secretion and the subsequent development after 10 years of duodenal ulcers or dyspepsia.Young, healthy medical students have a fairly high mean basal and maximal acid output. There was very little difference in the mean acid outputs of the various ABO blood groups. A significant correlation was shown between acid output and body weight and fat-free body mass, but not with the other measurements of body build. Basal acid output was also related to the number of cigarettes smoked per day. Three students who subsequently developed duodenal ulcers all had a preexistent high level of acid secretion. The acid output was, however, similar in the groups who developed significant or minor dyspepsia or who remained asymptomatic.Gastric acid secretion varies with many physiological and pathological factors and the maximal acid output has been shown to be directly related to the parietal cell mass by Card and Marks (1960). There are still varying opinions about the relationship of gastric acid secretion and body habitus.

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supporting

confidence: 75%

“…Hume and Melrose (1967) showed a significant correlation with lean body mass. This was confirmed more recently by Desai, Zaveri, and Antia (1972) with body weight in controls.…”

supporting

confidence: 75%